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9I6A

Crystal structure of human Cdc20 bound to synthetic D-box peptide D7

Functional Information from GO Data
ChainGOidnamespacecontents
A0000086biological_processG2/M transition of mitotic cell cycle
A0000775cellular_componentchromosome, centromeric region
A0000776cellular_componentkinetochore
A0000922cellular_componentspindle pole
A0005515molecular_functionprotein binding
A0005654cellular_componentnucleoplasm
A0005680cellular_componentanaphase-promoting complex
A0005694cellular_componentchromosome
A0005737cellular_componentcytoplasm
A0005813cellular_componentcentrosome
A0005819cellular_componentspindle
A0005829cellular_componentcytosol
A0005856cellular_componentcytoskeleton
A0007064biological_processmitotic sister chromatid cohesion
A0007094biological_processmitotic spindle assembly checkpoint signaling
A0007346biological_processregulation of mitotic cell cycle
A0007399biological_processnervous system development
A0008284biological_processpositive regulation of cell population proliferation
A0010997molecular_functionanaphase-promoting complex binding
A0016567biological_processprotein ubiquitination
A0016579biological_processprotein deubiquitination
A0030154biological_processcell differentiation
A0031145biological_processanaphase-promoting complex-dependent catabolic process
A0031146biological_processSCF-dependent proteasomal ubiquitin-dependent protein catabolic process
A0031915biological_processpositive regulation of synaptic plasticity
A0032991cellular_componentprotein-containing complex
A0033597cellular_componentmitotic checkpoint complex
A0040020biological_processregulation of meiotic nuclear division
A0042826molecular_functionhistone deacetylase binding
A0044784biological_processmetaphase/anaphase transition of cell cycle
A0045842biological_processpositive regulation of mitotic metaphase/anaphase transition
A0048471cellular_componentperinuclear region of cytoplasm
A0050773biological_processregulation of dendrite development
A0051301biological_processcell division
A0051445biological_processregulation of meiotic cell cycle
A0090129biological_processpositive regulation of synapse maturation
A0090307biological_processmitotic spindle assembly
A0097027molecular_functionubiquitin-protein transferase activator activity
A1904668biological_processpositive regulation of ubiquitin protein ligase activity
A1905786biological_processpositive regulation of anaphase-promoting complex-dependent catabolic process
A1990756molecular_functionubiquitin-like ligase-substrate adaptor activity
A1990757molecular_functionubiquitin ligase activator activity
A1990949biological_processmetaphase/anaphase transition of meiosis I
Functional Information from PROSITE/UniProt
site_idPS00678
Number of Residues15
DetailsWD_REPEATS_1 Trp-Asp (WD) repeats signature. TGGGtsDrHIRIWNV
ChainResidueDetails
ATHR373-VAL387

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues1
DetailsMOD_RES: Phosphoserine => ECO:0000269|PubMed:15525512, ECO:0007744|PubMed:23186163
ChainResidueDetails
ASER41

site_idSWS_FT_FI2
Number of Residues1
DetailsMOD_RES: N6-acetyllysine => ECO:0000269|PubMed:22014574
ChainResidueDetails
ALYS66

site_idSWS_FT_FI3
Number of Residues1
DetailsMOD_RES: Phosphothreonine => ECO:0000269|PubMed:14657031, ECO:0007744|PubMed:23186163
ChainResidueDetails
ATHR70

site_idSWS_FT_FI4
Number of Residues4
DetailsMOD_RES: Phosphoserine => ECO:0000269|PubMed:15525512
ChainResidueDetails
ASER72
ASER92
ASER153
ASER161

site_idSWS_FT_FI5
Number of Residues1
DetailsMOD_RES: Phosphothreonine => ECO:0000269|PubMed:14657031
ChainResidueDetails
ATHR106

site_idSWS_FT_FI6
Number of Residues1
DetailsMOD_RES: Phosphothreonine => ECO:0000269|PubMed:15525512
ChainResidueDetails
ATHR157

site_idSWS_FT_FI7
Number of Residues3
DetailsCROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:21926987
ChainResidueDetails
ALYS485
ALYS490

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PDB entries from 2025-07-02

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