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5Y93

Crystal Structure Analysis of the BRD4

Summary for 5Y93
Entry DOI10.2210/pdb5y93/pdb
DescriptorBromodomain-containing protein 4, 2-[[5-[(5-bromanyl-2-methoxy-phenyl)sulfonylamino]-3-methyl-1,2-benzoxazol-6-yl]oxy]-N-(2-morpholin-4-ylethyl)ethanamide, NITRATE ION, ... (6 entities in total)
Functional Keywordsbrd4(1), bromodomain, transcription
Biological sourceHomo sapiens (Human)
Total number of polymer chains1
Total formula weight17721.04
Authors
Xu, Y.,Zhang, Y.,Song, M.,Wang, C. (deposition date: 2017-08-22, release date: 2018-06-13, Last modification date: 2024-03-27)
Primary citationZhang, M.,Zhang, Y.,Song, M.,Xue, X.,Wang, J.,Wang, C.,Zhang, C.,Li, C.,Xiang, Q.,Zou, L.,Wu, X.,Wu, C.,Dong, B.,Xue, W.,Zhou, Y.,Chen, H.,Wu, D.,Ding, K.,Xu, Y.
Structure-Based Discovery and Optimization of Benzo[ d]isoxazole Derivatives as Potent and Selective BET Inhibitors for Potential Treatment of Castration-Resistant Prostate Cancer (CRPC)
J. Med. Chem., 61:3037-3058, 2018
Cited by
PubMed: 29566488
DOI: 10.1021/acs.jmedchem.8b00103
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.62 Å)
Structure validation

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