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8Q76
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BU of 8q76 by Molmil
Copper-transporting ATPase HMA4 in E2P state with BeF
Descriptor: Copper-transporting ATPase HMA4, MAGNESIUM ION
Authors:Guo, Z, Gourdon, P, Wang, K.
Deposit date:2023-08-15
Release date:2024-06-26
Last modified:2025-07-02
Method:ELECTRON MICROSCOPY (3.29 Å)
Cite:Diverse roles of the metal binding domains and transport mechanism of copper transporting P-type ATPases.
Nat Commun, 15, 2024
8Q73
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BU of 8q73 by Molmil
Copper-transporting ATPase HMA4 in E1 state apo
Descriptor: Copper-transporting ATPase HMA4
Authors:Guo, Z, Gourdon, P, Wang, K.
Deposit date:2023-08-15
Release date:2024-06-26
Method:ELECTRON MICROSCOPY (3.58 Å)
Cite:Diverse roles of the metal binding domains and transport mechanism of copper transporting P-type ATPases.
Nat Commun, 15, 2024
7CWS
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BU of 7cws by Molmil
SARS-CoV-2 Spike Proteins Trimer in Complex with FC05 and H014 Fabs Cocktail
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Heavy Chain of FC05 Fab, ...
Authors:Wang, L, Wang, X.
Deposit date:2020-08-31
Release date:2020-12-16
Last modified:2024-10-30
Method:ELECTRON MICROSCOPY (3.4 Å)
Cite:Structure-based development of human antibody cocktails against SARS-CoV-2.
Cell Res., 31, 2021
7XFR
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BU of 7xfr by Molmil
Crystal structure of WIPI2b in complex with the second site of ATG16L1
Descriptor: Autophagy-related protein 16-1, Isoform 2 of WD repeat domain phosphoinositide-interacting protein 2
Authors:Gong, X.Y, Pan, L.F.
Deposit date:2022-04-02
Release date:2023-03-08
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (1.76 Å)
Cite:ATG16L1 adopts a dual-binding site mode to interact with WIPI2b in autophagy.
Sci Adv, 9, 2023
7NUE
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BU of 7nue by Molmil
Crystal structure of mouse PRMT6 in complex with inhibitor EML736
Descriptor: Protein arginine N-methyltransferase 6, methyl 6-[5-[[~{N}-[[(2~{R},3~{S},4~{R},5~{R})-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methyl]carbamimidoyl]amino]pentylcarbamoylamino]-4-oxidanyl-naphthalene-2-carboxylate
Authors:Bonnefond, L, Cavarelli, J.
Deposit date:2021-03-11
Release date:2022-03-23
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (2 Å)
Cite:Turning Nonselective Inhibitors of Type I Protein Arginine Methyltransferases into Potent and Selective Inhibitors of Protein Arginine Methyltransferase 4 through a Deconstruction-Reconstruction and Fragment-Growing Approach.
J.Med.Chem., 65, 2022
7NUD
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BU of 7nud by Molmil
Crystal structure of mouse PRMT6 in complex with inhibitor EML734
Descriptor: Protein arginine N-methyltransferase 6, methyl 6-[3-[[~{N}-[[(2~{R},3~{S},4~{R},5~{R})-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methyl]carbamimidoyl]amino]propylcarbamoylamino]-4-oxidanyl-naphthalene-2-carboxylate
Authors:Bonnefond, L, Cavarelli, J.
Deposit date:2021-03-11
Release date:2022-03-23
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:Turning Nonselective Inhibitors of Type I Protein Arginine Methyltransferases into Potent and Selective Inhibitors of Protein Arginine Methyltransferase 4 through a Deconstruction-Reconstruction and Fragment-Growing Approach.
J.Med.Chem., 65, 2022
7XGW
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BU of 7xgw by Molmil
Apo structure of LW domain from Trypanosoma brucei
Descriptor: Transcription elongation factor s-II
Authors:Liao, S, Gao, J, Chen, M, Tu, X.
Deposit date:2022-04-06
Release date:2023-05-31
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:Structural basis for evolutionarily conserved interactions between TFIIS and Paf1C.
Int.J.Biol.Macromol., 253, 2023
7XY9
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BU of 7xy9 by Molmil
Cryo-EM structure of secondary alcohol dehydrogenases TbSADH after carrier-free immobilization based on weak intermolecular interactions
Descriptor: MAGNESIUM ION, NADP-dependent isopropanol dehydrogenase, ZINC ION
Authors:Chen, Q, Li, X, Yang, F, Qu, G, Sun, Z.T, Wang, Y.J.
Deposit date:2022-06-01
Release date:2023-06-07
Last modified:2024-05-08
Method:ELECTRON MICROSCOPY (2.12 Å)
Cite:Active and stable alcohol dehydrogenase-assembled hydrogels via synergistic bridging of triazoles and metal ions.
Nat Commun, 14, 2023
6V2R
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BU of 6v2r by Molmil
Crystal Structure of chromodomain of CBX7 mutant V13A in complex with inhibitor UNC3866
Descriptor: Chromobox protein homolog 7, UNC3866, UNKNOWN ATOM OR ION
Authors:Liu, Y, Tempel, W, Walker, J.R, Stuckey, J.I, Dickson, B.M, James, L.I, Frye, S.V, Bountra, C, Arrowsmith, C.H, Edwards, A.M, Min, J, Structural Genomics Consortium (SGC)
Deposit date:2019-11-25
Release date:2019-12-25
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Structural Basis for the Binding Selectivity of Human CDY Chromodomains.
Cell Chem Biol, 27, 2020
6V3N
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BU of 6v3n by Molmil
Crystal structure of CDYL2 in complex with H3K27me3
Descriptor: ACE-GLN-LEU-ALA-THR-LYS-ALA-ALA-ARG-M3L-SER-ALA-PRO-ALA-THR-TYR-NH2, Chromodomain Y-like protein 2, UNKNOWN ATOM OR ION
Authors:Qin, S, Tempel, W, Arrowsmith, C.H, Bountra, C, Edwards, A.M, Min, J, Structural Genomics Consortium, Structural Genomics Consortium (SGC)
Deposit date:2019-11-26
Release date:2020-04-01
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Structural Basis for the Binding Selectivity of Human CDY Chromodomains.
Cell Chem Biol, 27, 2020
6V41
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BU of 6v41 by Molmil
crystal structure of CDY1 chromodomain bound to H3K9me3
Descriptor: Histone H3.1 Peptide, Testis-specific chromodomain protein Y 1, UNKNOWN ATOM OR ION
Authors:Qin, S, Tempel, W, Walker, J.R, Arrowsmith, C.H, Bountra, C, Edwards, A.M, Min, J, Structural Genomics Consortium, Structural Genomics Consortium (SGC)
Deposit date:2019-11-27
Release date:2019-12-25
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (1.603 Å)
Cite:Structural Basis for the Binding Selectivity of Human CDY Chromodomains.
Cell Chem Biol, 27, 2020
6V2D
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BU of 6v2d by Molmil
Crystal Structure of chromodomain of CDYL2 in complex with inhibitor UNC3866
Descriptor: Chromodomain Y-like protein 2, UNC3866, UNKNOWN ATOM OR ION
Authors:Liu, Y, Tempel, W, Bountra, C, Arrowsmith, C.H, Edwards, A.M, Min, J, Structural Genomics Consortium (SGC)
Deposit date:2019-11-22
Release date:2019-12-25
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structural Basis for the Binding Selectivity of Human CDY Chromodomains.
Cell Chem Biol, 27, 2020
6V8W
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BU of 6v8w by Molmil
CDYL2 chromodomain in complex with a synthetic peptide
Descriptor: Chromodomain Y-like protein 2, IVA-PHE-ALA-PHE-5T3-SER-NH2, UNKNOWN ATOM OR ION
Authors:Dong, C, Tempel, W, James, L.I, Lamb, K.N, Bountra, C, Edwards, A.M, Arrowsmith, C.H, Min, J, Structural Genomics Consortium, Structural Genomics Consortium (SGC)
Deposit date:2019-12-12
Release date:2020-01-15
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Structural Basis for the Binding Selectivity of Human CDY Chromodomains.
Cell Chem Biol, 27, 2020
5YOV
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BU of 5yov by Molmil
Crystal structure of BRD4-BD1 bound with hjp126
Descriptor: (3~{R})-4-cyclopentyl-~{N}-(2,4-dimethylphenyl)-1,3-dimethyl-2-oxidanylidene-3~{H}-quinoxaline-6-carboxamide, Bromodomain-containing protein 4
Authors:Xiong, B, Hu, J, Li, Y, Cao, D.
Deposit date:2017-10-31
Release date:2018-11-07
Last modified:2024-03-27
Method:X-RAY DIFFRACTION (1.451 Å)
Cite:Structure-based optimization of a series of selective BET inhibitors containing aniline or indoline groups.
Eur.J.Med.Chem., 150, 2018
9CDD
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BU of 9cdd by Molmil
Kalium channelrhodopsin 1 C110A mutant from Hyphochytrium catenoides, Laser-Flash-Illuminated
Descriptor: 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine, CHOLESTEROL, Kalium Channelrhodopsin 1, ...
Authors:Morizumi, T, Kim, K, Ernst, O.P.
Deposit date:2024-06-24
Release date:2025-02-19
Method:ELECTRON MICROSCOPY (3.05 Å)
Cite:Structural insights into light-gating of potassium-selective channelrhodopsin.
Nat Commun, 16, 2025
9CDC
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BU of 9cdc by Molmil
Kalium channelrhodopsin 1 C110A mutant from Hyphochytrium catenoides, Dark State
Descriptor: 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine, CHOLESTEROL, Kalium channelrhodopsin 1 C110A, ...
Authors:Morizumi, T, Kim, K, Ernst, O.P.
Deposit date:2024-06-24
Release date:2025-02-19
Method:ELECTRON MICROSCOPY (3.08 Å)
Cite:Structural insights into light-gating of potassium-selective channelrhodopsin.
Nat Commun, 16, 2025
9CDE
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BU of 9cde by Molmil
Kalium channelrhodopsin 1 C110A mutant from Hyphochytrium catenoides, Continuous Illumination State
Descriptor: 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine, CHOLESTEROL, Kalium Channelrhodopsin 1 C110A - Continuous Illumination State, ...
Authors:Morizumi, T, Kim, K, Ernst, O.P.
Deposit date:2024-06-24
Release date:2025-02-19
Method:ELECTRON MICROSCOPY (3.44 Å)
Cite:Structural insights into light-gating of potassium-selective channelrhodopsin.
Nat Commun, 16, 2025
7BVH
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BU of 7bvh by Molmil
Crystal structure of arabinosyltransferase EmbC2-AcpM2 complex from Mycobacterium smegmatis complexed with di-arabinose
Descriptor: CALCIUM ION, Integral membrane indolylacetylinositol arabinosyltransferase EmbC, Meromycolate extension acyl carrier protein, ...
Authors:Zhao, Y, Zhang, L, Wu, L.J, Wang, Q, Li, J, Besra, G.S, Rao, Z.H.
Deposit date:2020-04-10
Release date:2020-04-29
Last modified:2024-11-13
Method:X-RAY DIFFRACTION (3.3 Å)
Cite:Structures of cell wall arabinosyltransferases with the anti-tuberculosis drug ethambutol.
Science, 368, 2020
7BVC
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BU of 7bvc by Molmil
Cryo-EM structure of Mycobacterium smegmatis arabinosyltransferase EmbA-EmbB-AcpM2 in complex with ethambutol
Descriptor: 4'-PHOSPHOPANTETHEINE, CALCIUM ION, CARDIOLIPIN, ...
Authors:Zhang, L, Zhao, Y, Gao, Y, Wang, Q, Li, J, Besra, G.S, Rao, Z.
Deposit date:2020-04-10
Release date:2020-04-29
Last modified:2025-04-09
Method:ELECTRON MICROSCOPY (2.9 Å)
Cite:Structures of cell wall arabinosyltransferases with the anti-tuberculosis drug ethambutol.
Science, 368, 2020
7BVF
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BU of 7bvf by Molmil
Cryo-EM structure of Mycobacterium tuberculosis arabinosyltransferase EmbA-EmbB-AcpM2 in complex with ethambutol
Descriptor: CALCIUM ION, CARDIOLIPIN, Ethambutol, ...
Authors:Zhang, L, Zhao, Y, Gao, Y, Wang, Q, Li, J, Besra, G.S, Rao, Z.
Deposit date:2020-04-10
Release date:2020-04-29
Last modified:2024-03-27
Method:ELECTRON MICROSCOPY (2.97 Å)
Cite:Structures of cell wall arabinosyltransferases with the anti-tuberculosis drug ethambutol.
Science, 368, 2020
7BVE
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BU of 7bve by Molmil
Cryo-EM structure of Mycobacterium smegmatis arabinosyltransferase EmbC2-AcpM2 in complex with ethambutol
Descriptor: CALCIUM ION, Ethambutol, Integral membrane indolylacetylinositol arabinosyltransferase EmbC, ...
Authors:Zhang, L, Zhao, Y, Gao, Y, Wang, Q, Li, J, Besra, G.S, Rao, Z.
Deposit date:2020-04-10
Release date:2020-04-29
Last modified:2024-11-06
Method:ELECTRON MICROSCOPY (2.81 Å)
Cite:Structures of cell wall arabinosyltransferases with the anti-tuberculosis drug ethambutol.
Science, 368, 2020
7BVG
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BU of 7bvg by Molmil
Cryo-EM structure of Mycobacterium smegmatis arabinosyltransferase EmbA-EmbB-AcpM2 in complex with di-arabinose.
Descriptor: 4'-PHOSPHOPANTETHEINE, CALCIUM ION, CARDIOLIPIN, ...
Authors:Zhang, L, Zhao, Y, Gao, Y, Wang, Q, Li, J, Besra, G.S, Rao, Z.
Deposit date:2020-04-10
Release date:2020-04-29
Last modified:2024-03-27
Method:ELECTRON MICROSCOPY (3.1 Å)
Cite:Structures of cell wall arabinosyltransferases with the anti-tuberculosis drug ethambutol.
Science, 368, 2020
8E59
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BU of 8e59 by Molmil
Human L-type voltage-gated calcium channel Cav1.3 in the presence of Amiodarone at 3.1 Angstrom resolution
Descriptor: (2-butyl-1-benzofuran-3-yl){4-[2-(diethylamino)ethoxy]-3,5-diiodophenyl}methanone, 1,2-Distearoyl-sn-glycerophosphoethanolamine, 2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Gao, S, Yao, X, Yan, N.
Deposit date:2022-08-20
Release date:2022-12-07
Last modified:2025-05-21
Method:ELECTRON MICROSCOPY (3.1 Å)
Cite:Structural basis for the severe adverse interaction of sofosbuvir and amiodarone on L-type Ca v channels.
Cell, 185, 2022
8E5B
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BU of 8e5b by Molmil
Human L-type voltage-gated calcium channel Cav1.3 in the presence of Amiodarone and Sofosbuvir at 3.3 Angstrom resolution
Descriptor: (2-butyl-1-benzofuran-3-yl){4-[2-(diethylamino)ethoxy]-3,5-diiodophenyl}methanone, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Gao, S, Yao, X, Yan, N.
Deposit date:2022-08-20
Release date:2022-12-07
Last modified:2025-05-28
Method:ELECTRON MICROSCOPY (3.3 Å)
Cite:Structural basis for the severe adverse interaction of sofosbuvir and amiodarone on L-type Ca v channels.
Cell, 185, 2022
8E5A
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BU of 8e5a by Molmil
Human L-type voltage-gated calcium channel Cav1.3 treated with 1.4 mM Sofosbuvir at 3.3 Angstrom resolution
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Gao, S, Yao, X, Yan, N.
Deposit date:2022-08-20
Release date:2022-12-07
Last modified:2025-05-28
Method:ELECTRON MICROSCOPY (3.3 Å)
Cite:Structural basis for the severe adverse interaction of sofosbuvir and amiodarone on L-type Ca v channels.
Cell, 185, 2022

238895

數據於2025-07-16公開中

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