8E59

Human L-type voltage-gated calcium channel Cav1.3 in the presence of Amiodarone at 3.1 Angstrom resolution

Summary for 8E59

• Entry DOI: 10.2210/pdb8e59/pdb
• EMDB information: 27907
• Related PRD ID: PRD_900017
• Descriptor: Voltage-dependent L-type calcium channel subunit alpha-1D, 2-acetamido-2-deoxy-beta-D-glucopyranose, Voltage-dependent calcium channel subunit alpha-2/delta-1, ... (10 entities in total)
• Functional Keywords: cav1.3, channels, calcium ion-selective, transport protein
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 3
• Total formula weight: 429365.59

Authors

Gao, S.,Yao, X.,Yan, N. (deposition date: 2022-08-20, release date: 2022-12-07, Last modification date: 2022-12-21)

• Primary citation: Yao, X.,Gao, S.,Wang, J.,Li, Z.,Huang, J.,Wang, Y.,Wang, Z.,Chen, J.,Fan, X.,Wang, W.,Jin, X.,Pan, X.,Yu, Y.,Lagrutta, A.,Yan, N.; Structural basis for the severe adverse interaction of sofosbuvir and amiodarone on L-type Ca v channels.; Cell, 185:4801-4810.e13, 2022; PubMed: 36417914; DOI: 10.1016/j.cell.2022.10.024

Experimental method

ELECTRON MICROSCOPY (3.1 Å)