7BVE

Cryo-EM structure of Mycobacterium smegmatis arabinosyltransferase EmbC2-AcpM2 in complex with ethambutol

Summary for 7BVE

• Entry DOI: 10.2210/pdb7bve/pdb
• EMDB information: 30217
• Descriptor: Integral membrane indolylacetylinositol arabinosyltransferase EmbC, Meromycolate extension acyl carrier protein, CALCIUM ION, ... (6 entities in total)
• Functional Keywords: mycobacterium smegmatis, cell wall synthesis, drug target, ethambutol, arabinosyltransferase, embc, acyl carrier protein, arabinogalactan, lipoarabinomannan, drug resistance, transferase
• Biological source: Mycolicibacterium smegmatis (strain ATCC 700084 / mc(2)155); More
• Total number of polymer chains: 4
• Total formula weight: 256640.96

Authors

Zhang, L.,Zhao, Y.,Gao, Y.,Wang, Q.,Li, J.,Besra, G.S.,Rao, Z. (deposition date: 2020-04-10, release date: 2020-04-29, Last modification date: 2020-07-01)

• Primary citation: Zhang, L.,Zhao, Y.,Gao, Y.,Wu, L.,Gao, R.,Zhang, Q.,Wang, Y.,Wu, C.,Wu, F.,Gurcha, S.S.,Veerapen, N.,Batt, S.M.,Zhao, W.,Qin, L.,Yang, X.,Wang, M.,Zhu, Y.,Zhang, B.,Bi, L.,Zhang, X.,Yang, H.,Guddat, L.W.,Xu, W.,Wang, Q.,Li, J.,Besra, G.S.,Rao, Z.; Structures of cell wall arabinosyltransferases with the anti-tuberculosis drug ethambutol.; Science, 368:1211-1219, 2020; PubMed: 32327601; DOI: 10.1126/science.aba9102

Experimental method

ELECTRON MICROSCOPY (2.81 Å)