7BVE
Cryo-EM structure of Mycobacterium smegmatis arabinosyltransferase EmbC2-AcpM2 in complex with ethambutol
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0016740 | molecular_function | transferase activity |
| A | 0016757 | molecular_function | glycosyltransferase activity |
| A | 0046872 | molecular_function | metal ion binding |
| A | 0052636 | molecular_function | arabinosyltransferase activity |
| A | 0071555 | biological_process | cell wall organization |
| A | 0071766 | biological_process | Actinobacterium-type cell wall biogenesis |
| B | 0005886 | cellular_component | plasma membrane |
| B | 0016740 | molecular_function | transferase activity |
| B | 0016757 | molecular_function | glycosyltransferase activity |
| B | 0046872 | molecular_function | metal ion binding |
| B | 0052636 | molecular_function | arabinosyltransferase activity |
| B | 0071555 | biological_process | cell wall organization |
| B | 0071766 | biological_process | Actinobacterium-type cell wall biogenesis |
| C | 0000035 | molecular_function | acyl binding |
| C | 0000036 | molecular_function | acyl carrier activity |
| C | 0005737 | cellular_component | cytoplasm |
| C | 0005829 | cellular_component | cytosol |
| C | 0006629 | biological_process | lipid metabolic process |
| C | 0006631 | biological_process | fatty acid metabolic process |
| C | 0006633 | biological_process | fatty acid biosynthetic process |
| C | 0009245 | biological_process | lipid A biosynthetic process |
| C | 0016020 | cellular_component | membrane |
| D | 0000035 | molecular_function | acyl binding |
| D | 0000036 | molecular_function | acyl carrier activity |
| D | 0005737 | cellular_component | cytoplasm |
| D | 0005829 | cellular_component | cytosol |
| D | 0006629 | biological_process | lipid metabolic process |
| D | 0006631 | biological_process | fatty acid metabolic process |
| D | 0006633 | biological_process | fatty acid biosynthetic process |
| D | 0009245 | biological_process | lipid A biosynthetic process |
| D | 0016020 | cellular_component | membrane |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | binding site for residue CA A 1101 |
| Chain | Residue |
| A | ASP929 |
| A | ASP931 |
| A | ALA933 |
| A | HIS936 |
| site_id | AC2 |
| Number of Residues | 3 |
| Details | binding site for residue PO4 A 1102 |
| Chain | Residue |
| A | ARG383 |
| A | THR570 |
| A | 95E1103 |
| site_id | AC3 |
| Number of Residues | 7 |
| Details | binding site for residue 95E A 1103 |
| Chain | Residue |
| A | ILE283 |
| A | ARG383 |
| A | TRP965 |
| A | VAL1004 |
| A | PO41102 |
| A | ASP279 |
| A | TYR282 |
| site_id | AC4 |
| Number of Residues | 4 |
| Details | binding site for residue CA B 1101 |
| Chain | Residue |
| B | ASP929 |
| B | ASP931 |
| B | ALA933 |
| B | HIS936 |
| site_id | AC5 |
| Number of Residues | 3 |
| Details | binding site for residue PO4 B 1102 |
| Chain | Residue |
| B | ARG383 |
| B | THR570 |
| B | 95E1103 |
| site_id | AC6 |
| Number of Residues | 7 |
| Details | binding site for residue 95E B 1103 |
| Chain | Residue |
| B | ASP279 |
| B | TYR282 |
| B | ILE283 |
| B | ARG383 |
| B | TRP965 |
| B | VAL1004 |
| B | PO41102 |
| site_id | AC7 |
| Number of Residues | 9 |
| Details | binding site for Di-peptide PN7 C 101 and SER C 41 |
| Chain | Residue |
| A | HIS245 |
| A | ARG247 |
| A | SER251 |
| A | ARG401 |
| C | ASP40 |
| C | LEU42 |
| C | SER43 |
| C | MET44 |
| C | VAL45 |
| site_id | AC8 |
| Number of Residues | 9 |
| Details | binding site for Di-peptide PN7 D 101 and SER D 41 |
| Chain | Residue |
| B | HIS245 |
| B | ARG247 |
| B | SER251 |
| B | ARG401 |
| D | ASP40 |
| D | LEU42 |
| D | SER43 |
| D | MET44 |
| D | VAL45 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI5 |
| Number of Residues | 156 |
| Details | Domain: {"description":"Carrier","evidences":[{"source":"PROSITE-ProRule","id":"PRU00258","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"O-(pantetheine 4'-phosphoryl)serine","evidences":[{"source":"PROSITE-ProRule","id":"PRU00258","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 4 |
| Details | Cross-link: {"description":"Isoglutamyl lysine isopeptide (Lys-Gln) (interchain with Q-Cter in protein Pup)","evidences":[{"source":"PubMed","id":"20094657","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
