7BVF

Cryo-EM structure of Mycobacterium tuberculosis arabinosyltransferase EmbA-EmbB-AcpM2 in complex with ethambutol

Summary for 7BVF

• Entry DOI: 10.2210/pdb7bvf/pdb
• EMDB information: 30218
• Descriptor: Probable arabinosyltransferase B, Probable arabinosyltransferase A, Meromycolate extension acyl carrier protein, ... (7 entities in total)
• Functional Keywords: mycobacterium tuberculosis, cell wall synthesis, drug target, ethambutol, arabinosyltransferase, emba, embb, embc, acyl carrier protein, arabinogalactan, lipoarabinomannan, drug resistance, transferase
• Biological source: Mycobacterium tuberculosis H37Rv; More
• Total number of polymer chains: 3
• Total formula weight: 251817.41

Authors

Zhang, L.,Zhao, Y.,Gao, Y.,Wang, Q.,Li, J.,Besra, G.S.,Rao, Z. (deposition date: 2020-04-10, release date: 2020-04-29, Last modification date: 2024-03-27)

• Primary citation: Zhang, L.,Zhao, Y.,Gao, Y.,Wu, L.,Gao, R.,Zhang, Q.,Wang, Y.,Wu, C.,Wu, F.,Gurcha, S.S.,Veerapen, N.,Batt, S.M.,Zhao, W.,Qin, L.,Yang, X.,Wang, M.,Zhu, Y.,Zhang, B.,Bi, L.,Zhang, X.,Yang, H.,Guddat, L.W.,Xu, W.,Wang, Q.,Li, J.,Besra, G.S.,Rao, Z.; Structures of cell wall arabinosyltransferases with the anti-tuberculosis drug ethambutol.; Science, 368:1211-1219, 2020; PubMed: 32327601; DOI: 10.1126/science.aba9102

Experimental method

ELECTRON MICROSCOPY (2.97 Å)