7BVF
Cryo-EM structure of Mycobacterium tuberculosis arabinosyltransferase EmbA-EmbB-AcpM2 in complex with ethambutol
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005829 | cellular_component | cytosol |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0016020 | cellular_component | membrane |
| A | 0016740 | molecular_function | transferase activity |
| A | 0016757 | molecular_function | glycosyltransferase activity |
| A | 0046677 | biological_process | response to antibiotic |
| A | 0052636 | molecular_function | arabinosyltransferase activity |
| A | 0071555 | biological_process | cell wall organization |
| A | 0071766 | biological_process | Actinobacterium-type cell wall biogenesis |
| B | 0005886 | cellular_component | plasma membrane |
| B | 0009274 | cellular_component | peptidoglycan-based cell wall |
| B | 0016020 | cellular_component | membrane |
| B | 0016740 | molecular_function | transferase activity |
| B | 0016757 | molecular_function | glycosyltransferase activity |
| B | 0046677 | biological_process | response to antibiotic |
| B | 0052636 | molecular_function | arabinosyltransferase activity |
| B | 0071555 | biological_process | cell wall organization |
| B | 0071766 | biological_process | Actinobacterium-type cell wall biogenesis |
| P | 0000035 | molecular_function | acyl binding |
| P | 0000036 | molecular_function | acyl carrier activity |
| P | 0005737 | cellular_component | cytoplasm |
| P | 0005829 | cellular_component | cytosol |
| P | 0006629 | biological_process | lipid metabolic process |
| P | 0006631 | biological_process | fatty acid metabolic process |
| P | 0006633 | biological_process | fatty acid biosynthetic process |
| P | 0009245 | biological_process | lipid A biosynthetic process |
| P | 0016020 | cellular_component | membrane |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 3 |
| Details | binding site for residue CA B 1401 |
| Chain | Residue |
| B | ASP952 |
| B | SER954 |
| B | ASP959 |
| site_id | AC2 |
| Number of Residues | 6 |
| Details | binding site for residue 95E B 1402 |
| Chain | Residue |
| B | ASP299 |
| B | TYR302 |
| B | GLU327 |
| B | HIS594 |
| B | TRP988 |
| B | DSL1403 |
| site_id | AC3 |
| Number of Residues | 11 |
| Details | binding site for residue DSL B 1403 |
| Chain | Residue |
| B | ARG403 |
| B | VAL435 |
| B | GLN445 |
| B | PRO446 |
| B | THR506 |
| B | ARG509 |
| B | PRO514 |
| B | PRO589 |
| B | THR590 |
| B | TRP592 |
| B | 95E1402 |
| site_id | AC4 |
| Number of Residues | 7 |
| Details | binding site for residue CDL B 1404 |
| Chain | Residue |
| A | ARG537 |
| A | ARG601 |
| A | HIS665 |
| B | ARG568 |
| B | TRP572 |
| B | PHE579 |
| B | PHE583 |
| site_id | AC5 |
| Number of Residues | 7 |
| Details | binding site for residue CDL A 1101 |
| Chain | Residue |
| A | LEU433 |
| A | ARG437 |
| A | TRP550 |
| A | LEU561 |
| B | ARG559 |
| B | ARG623 |
| B | HIS687 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 521 |
| Details | Transmembrane: {"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 78 |
| Details | Domain: {"description":"Carrier","evidences":[{"source":"PROSITE-ProRule","id":"PRU00258","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"O-(pantetheine 4'-phosphoryl)serine","evidences":[{"source":"PROSITE-ProRule","id":"PRU00258","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | Cross-link: {"description":"Isoglutamyl lysine isopeptide (Lys-Gln) (interchain with Q-Cter in protein Pup)","evidences":[{"source":"PubMed","id":"20094657","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
