8HF3
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![BU of 8hf3 by Molmil](/molmil-images/mine/8hf3) | Cryo-EM structure of human ZDHHC9/GCP16 complex | Descriptor: | 1,2-DILAUROYL-SN-GLYCERO-3-PHOSPHATE, Golgin subfamily A member 7, PALMITIC ACID, ... | Authors: | Wu, J, Hu, Q, Zhang, Y, Liu, S, Yang, A. | Deposit date: | 2022-11-09 | Release date: | 2023-11-22 | Last modified: | 2024-06-05 | Method: | ELECTRON MICROSCOPY (3.4 Å) | Cite: | Regulation of RAS palmitoyltransferases by accessory proteins and palmitoylation. Nat.Struct.Mol.Biol., 31, 2024
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7X9G
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![BU of 7x9g by Molmil](/molmil-images/mine/7x9g) | Crystal structure of human EDA and EDAR | Descriptor: | Ectodysplasin-A, secreted form, Tumor necrosis factor receptor superfamily member EDAR | Authors: | Yu, K, Wan, F, Huang, C, Wu, J, Lei, M. | Deposit date: | 2022-03-15 | Release date: | 2023-02-22 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Structural insights into pathogenic mechanism of hypohidrotic ectodermal dysplasia caused by ectodysplasin A variants. Nat Commun, 14, 2023
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1I57
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![BU of 1i57 by Molmil](/molmil-images/mine/1i57) | CRYSTAL STRUCTURE OF APO HUMAN PTP1B (C215S) MUTANT | Descriptor: | CHLORIDE ION, MAGNESIUM ION, PHOSPHO-TYROSINE PHOSPHATASE 1B | Authors: | Scapin, G, Patel, S, Patel, V, Kennedy, B, Asante-Appiah, E. | Deposit date: | 2001-02-26 | Release date: | 2001-08-08 | Last modified: | 2023-08-09 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | The structure of apo protein-tyrosine phosphatase 1B C215S mutant: more than just an S --> O change. Protein Sci., 10, 2001
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8I0A
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![BU of 8i0a by Molmil](/molmil-images/mine/8i0a) | |
8JJB
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![BU of 8jjb by Molmil](/molmil-images/mine/8jjb) | Crystal structure of T2R-TTL-Y61 complex | Descriptor: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, CALCIUM ION, CHLORIDE ION, ... | Authors: | Yang, J. | Deposit date: | 2023-05-30 | Release date: | 2024-03-27 | Method: | X-RAY DIFFRACTION (2.68 Å) | Cite: | Structure-based design and synthesis of BML284 derivatives: A novel class of colchicine-site noncovalent tubulin degradation agents. Eur.J.Med.Chem., 268, 2024
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8JJC
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![BU of 8jjc by Molmil](/molmil-images/mine/8jjc) | Tubulin-Y62 | Descriptor: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 4-(6,7-dimethoxy-3,4-dihydro-1~{H}-isoquinolin-2-yl)-6-(3-methoxyphenyl)pyrimidin-2-amine, CALCIUM ION, ... | Authors: | Yang, J. | Deposit date: | 2023-05-30 | Release date: | 2024-03-27 | Method: | X-RAY DIFFRACTION (2.76 Å) | Cite: | Structure-based design and synthesis of BML284 derivatives: A novel class of colchicine-site noncovalent tubulin degradation agents. Eur.J.Med.Chem., 268, 2024
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8V7L
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![BU of 8v7l by Molmil](/molmil-images/mine/8v7l) | Cryo-EM structure of singly-bound SNF2h-nucleosome complex with SNF2h at inactive SHL2 (conformation 2) | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, Histone H2A type 1, Histone H2B, ... | Authors: | Chio, U.S, Palovcak, E, Armache, J.P, Narlikar, G.J, Cheng, Y. | Deposit date: | 2023-12-04 | Release date: | 2024-03-20 | Method: | ELECTRON MICROSCOPY (2.9 Å) | Cite: | Functionalized graphene-oxide grids enable high-resolution cryo-EM structures of the SNF2h-nucleosome complex without crosslinking. Nat Commun, 15, 2024
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8V6V
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![BU of 8v6v by Molmil](/molmil-images/mine/8v6v) | Cryo-EM structure of doubly-bound SNF2h-nucleosome complex | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, Histone H2A type 1, Histone H2B, ... | Authors: | Chio, U.S, Palovcak, E, Armache, J.P, Narlikar, G.J, Cheng, Y. | Deposit date: | 2023-12-03 | Release date: | 2024-03-20 | Method: | ELECTRON MICROSCOPY (2.8 Å) | Cite: | Functionalized graphene-oxide grids enable high-resolution cryo-EM structures of the SNF2h-nucleosome complex without crosslinking. Nat Commun, 15, 2024
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8V4Y
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![BU of 8v4y by Molmil](/molmil-images/mine/8v4y) | Cryo-EM structure of singly-bound SNF2h-nucleosome complex with SNF2h at inactive SHL2 (conformation 1) | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, BERYLLIUM TRIFLUORIDE ION, Histone H2A type 1, ... | Authors: | Chio, U.S, Palovcak, E, Armache, J.P, Narlikar, G.J, Cheng, Y. | Deposit date: | 2023-11-29 | Release date: | 2024-03-20 | Method: | ELECTRON MICROSCOPY (2.8 Å) | Cite: | Functionalized graphene-oxide grids enable high-resolution cryo-EM structures of the SNF2h-nucleosome complex without crosslinking. Nat Commun, 15, 2024
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8XOK
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![BU of 8xok by Molmil](/molmil-images/mine/8xok) | Cryo-EM structure of human ABCC4 | Descriptor: | 2-[2-[(1~{S},2~{S},4~{S},5'~{R},6~{R},7~{S},8~{R},9~{S},12~{S},13~{R},16~{S})-5',7,9,13-tetramethylspiro[5-oxapentacyclo[10.8.0.0^{2,9}.0^{4,8}.0^{13,18}]icos-18-ene-6,2'-oxane]-16-yl]oxyethyl]propane-1,3-diol, ATP-binding cassette sub-family C member 4, PALMITIC ACID | Authors: | Zhang, P.F, Liu, Z. | Deposit date: | 2024-01-01 | Release date: | 2024-07-24 | Method: | ELECTRON MICROSCOPY (2.84 Å) | Cite: | The ATP-bound inward-open conformation of ABCC4 reveals asymmetric ATP binding for substrate transport. Febs Lett., 2024
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8UVO
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![BU of 8uvo by Molmil](/molmil-images/mine/8uvo) | Human p97/VCP R155H mutant structure with a triazole inhibitor (NSC804515) | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, N-[3-(2,5-difluoro-4-{[(4M)-5-(hexylsulfanyl)-4-(pyridin-3-yl)-4H-1,2,4-triazol-3-yl]methoxy}phenyl)prop-2-yn-1-yl]propanamide, Transitional endoplasmic reticulum ATPase | Authors: | Nandi, P, DeVore, K, Chiu, P.-L. | Deposit date: | 2023-11-03 | Release date: | 2024-08-21 | Method: | ELECTRON MICROSCOPY (3.22 Å) | Cite: | Mechanism of allosteric inhibition of human p97/VCP ATPase and its disease mutant by triazole inhibitors. Commun Chem, 7, 2024
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8UVQ
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![BU of 8uvq by Molmil](/molmil-images/mine/8uvq) | Human p97/VCP R155H mutant structure with a triazole inhibitor (NSC819701/down) | Descriptor: | 2-[(4P)-4-(4-{[(4P)-5-(cyclohexylsulfanyl)-4-(pyridin-3-yl)-4H-1,2,4-triazol-3-yl]methoxy}-2,5-difluorophenyl)-2H-1,2,3-triazol-2-yl]-1-[(2R,6S)-2,6-dimethylmorpholin-4-yl]ethan-1-one, ADENOSINE-5'-DIPHOSPHATE, Transitional endoplasmic reticulum ATPase | Authors: | Nandi, P, DeVore, K, Chiu, P.-L. | Deposit date: | 2023-11-03 | Release date: | 2024-08-21 | Method: | ELECTRON MICROSCOPY (3.42 Å) | Cite: | Mechanism of allosteric inhibition of human p97/VCP ATPase and its disease mutant by triazole inhibitors. Commun Chem, 7, 2024
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8UVP
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![BU of 8uvp by Molmil](/molmil-images/mine/8uvp) | Human p97/VCP R155H mutant structure with a triazole inhibitor (NSC819701/up) | Descriptor: | 2-[(4P)-4-(4-{[(4P)-5-(cyclohexylsulfanyl)-4-(pyridin-3-yl)-4H-1,2,4-triazol-3-yl]methoxy}-2,5-difluorophenyl)-2H-1,2,3-triazol-2-yl]-1-[(2R,6S)-2,6-dimethylmorpholin-4-yl]ethan-1-one, ADENOSINE-5'-DIPHOSPHATE, Transitional endoplasmic reticulum ATPase | Authors: | Nandi, P, DeVore, K, Chiu, P.-L. | Deposit date: | 2023-11-03 | Release date: | 2024-08-21 | Method: | ELECTRON MICROSCOPY (3.6 Å) | Cite: | Mechanism of allosteric inhibition of human p97/VCP ATPase and its disease mutant by triazole inhibitors. Commun Chem, 7, 2024
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8UV2
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![BU of 8uv2 by Molmil](/molmil-images/mine/8uv2) | Human p97/VCP structure with a triazole inhibitor (NSC799462/hexamer) | Descriptor: | 3-(2,6-difluoro-4-{[(4P)-5-{[(2S)-hexan-2-yl]sulfanyl}-4-(pyridin-3-yl)-4H-1,2,4-triazol-3-yl]methoxy}phenyl)prop-2-yn-1-yl (1-methylpiperidin-4-yl)carbamate, ADENOSINE-5'-DIPHOSPHATE, Transitional endoplasmic reticulum ATPase | Authors: | Nandi, P, DeVore, K, Chiu, P.-L. | Deposit date: | 2023-11-02 | Release date: | 2024-08-21 | Method: | ELECTRON MICROSCOPY (3.23 Å) | Cite: | Mechanism of allosteric inhibition of human p97/VCP ATPase and its disease mutant by triazole inhibitors. Commun Chem, 7, 2024
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8XOL
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![BU of 8xol by Molmil](/molmil-images/mine/8xol) | Cryo-EM structure of human ABCC4 with ANP bound in NBD1 | Descriptor: | 2-[2-[(1~{S},2~{S},4~{S},5'~{R},6~{R},7~{S},8~{R},9~{S},12~{S},13~{R},16~{S})-5',7,9,13-tetramethylspiro[5-oxapentacyclo[10.8.0.0^{2,9}.0^{4,8}.0^{13,18}]icos-18-ene-6,2'-oxane]-16-yl]oxyethyl]propane-1,3-diol, ATP-binding cassette sub-family C member 4, MAGNESIUM ION, ... | Authors: | Zhang, P.F, Liu, Z. | Deposit date: | 2024-01-01 | Release date: | 2024-07-17 | Method: | ELECTRON MICROSCOPY (3.02 Å) | Cite: | The ATP-bound inward-open conformation of ABCC4 reveals asymmetric ATP binding for substrate transport. Febs Lett., 2024
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8XOM
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![BU of 8xom by Molmil](/molmil-images/mine/8xom) | Cryo-EM structure of human ABCC4 in complex with ANP-bound in NBD1 and METHOTREXATE | Descriptor: | 2-[2-[(1~{S},2~{S},4~{S},5'~{R},6~{R},7~{S},8~{R},9~{S},12~{S},13~{R},16~{S})-5',7,9,13-tetramethylspiro[5-oxapentacyclo[10.8.0.0^{2,9}.0^{4,8}.0^{13,18}]icos-18-ene-6,2'-oxane]-16-yl]oxyethyl]propane-1,3-diol, ATP-binding cassette sub-family C member 4, MAGNESIUM ION, ... | Authors: | Zhang, P.F, Liu, Z. | Deposit date: | 2024-01-01 | Release date: | 2024-07-17 | Method: | ELECTRON MICROSCOPY (3.05 Å) | Cite: | The ATP-bound inward-open conformation of ABCC4 reveals asymmetric ATP binding for substrate transport. Febs Lett., 2024
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6JLQ
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![BU of 6jlq by Molmil](/molmil-images/mine/6jlq) | Crystal structure of human USP46-WDR48-WDR20 complex | Descriptor: | GLYCEROL, PHOSPHATE ION, Ubiquitin carboxyl-terminal hydrolase 46, ... | Authors: | Zhu, H, Zhang, T, Ding, J. | Deposit date: | 2019-03-06 | Release date: | 2019-07-10 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (3.101 Å) | Cite: | Structural insights into the activation of USP46 by WDR48 and WDR20. Cell Discov, 5, 2019
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6HEQ
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![BU of 6heq by Molmil](/molmil-images/mine/6heq) | Prion nanobody 484 | Descriptor: | Prion nanobody 484 | Authors: | Soror, S.H, Abskharon, R.N, Wohlkonig, A. | Deposit date: | 2018-08-20 | Release date: | 2019-12-04 | Last modified: | 2019-12-18 | Method: | X-RAY DIFFRACTION (1.23 Å) | Cite: | Structural evidence for the critical role of the prion protein hydrophobic region in forming an infectious prion. Plos Pathog., 15, 2019
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6HER
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![BU of 6her by Molmil](/molmil-images/mine/6her) | Mouse prion protein in complex with Nanobody 484 | Descriptor: | GLYCEROL, Major prion protein, Nanobody 484, ... | Authors: | Soror, S.H, Abskharon, R, Wohlkonig, A. | Deposit date: | 2018-08-20 | Release date: | 2019-12-04 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (1.199 Å) | Cite: | Structural evidence for the critical role of the prion protein hydrophobic region in forming an infectious prion. Plos Pathog., 15, 2019
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4CLC
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![BU of 4clc by Molmil](/molmil-images/mine/4clc) | Crystal structure of Ybr137w protein | Descriptor: | UPF0303 PROTEIN YBR137W | Authors: | Yeh, Y.-H, Lin, T.-W, Lin, C.-Y, Hsiao, C.-D. | Deposit date: | 2014-01-14 | Release date: | 2014-11-19 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Structural and Functional Characterization of Ybr137Wp Implicate its Involvement in the Targeting of Tail-Anchored Proteins to Membranes. Mol.Cell.Biol., 34, 2014
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6KKT
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![BU of 6kkt by Molmil](/molmil-images/mine/6kkt) | human KCC1 structure determined in KCl and lipid nanodisc | Descriptor: | 2-[2-[(1~{S},2~{S},4~{S},5'~{R},6~{R},7~{S},8~{R},9~{S},12~{S},13~{R},16~{S})-5',7,9,13-tetramethylspiro[5-oxapentacyclo[10.8.0.0^{2,9}.0^{4,8}.0^{13,18}]icos-18-ene-6,2'-oxane]-16-yl]oxyethyl]propane-1,3-diol, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CHLORIDE ION, ... | Authors: | Liu, S, Chang, S, Ye, S, Bai, X, Guo, J. | Deposit date: | 2019-07-27 | Release date: | 2019-10-23 | Last modified: | 2020-08-12 | Method: | ELECTRON MICROSCOPY (2.9 Å) | Cite: | Cryo-EM structures of the human cation-chloride cotransporter KCC1. Science, 366, 2019
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6KJ0
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![BU of 6kj0 by Molmil](/molmil-images/mine/6kj0) | Bifunctional xylosidase/glucosidase LXYL mutant E529Q C2221 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Beta-D-xylosidase/beta-D-glucosidase, Deacetyltaxol, ... | Authors: | Gong, W.M, Yang, L.Y. | Deposit date: | 2019-07-20 | Release date: | 2020-02-26 | Last modified: | 2020-07-29 | Method: | X-RAY DIFFRACTION (2.27 Å) | Cite: | Structures of beta-glycosidase LXYL-P1-2 reveals the product binding state of GH3 family and a specific pocket for Taxol recognition. Commun Biol, 3, 2020
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6HHD
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![BU of 6hhd by Molmil](/molmil-images/mine/6hhd) | Mouse Prion Protein in complex with Nanobody 484 | Descriptor: | CHLORIDE ION, GLYCEROL, Major prion protein, ... | Authors: | Soror, S, Abskharon, R, Wohlkonig, A. | Deposit date: | 2018-08-28 | Release date: | 2019-12-11 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (2.102 Å) | Cite: | Structural evidence for the critical role of the prion protein hydrophobic region in forming an infectious prion. Plos Pathog., 15, 2019
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1DNV
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![BU of 1dnv by Molmil](/molmil-images/mine/1dnv) | PARVOVIRUS (DENSOVIRUS) FROM GALLERIA MELLONELLA | Descriptor: | GALLERIA MELLONELLA DENSOVIRUS CAPSID PROTEIN | Authors: | Simpson, A.A, Chipmann, P.R, Baker, T.S, Tijssen, P, Rossmann, M.G. | Deposit date: | 1998-07-22 | Release date: | 1999-02-16 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (3.6 Å) | Cite: | The structure of an insect parvovirus (Galleria mellonella densovirus) at 3.7 A resolution. Structure, 6, 1998
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6KKU
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![BU of 6kku by Molmil](/molmil-images/mine/6kku) | human KCC1 structure determined in NaCl and GDN | Descriptor: | 2-[2-[(1~{S},2~{S},4~{S},5'~{R},6~{R},7~{S},8~{R},9~{S},12~{S},13~{R},16~{S})-5',7,9,13-tetramethylspiro[5-oxapentacyclo[10.8.0.0^{2,9}.0^{4,8}.0^{13,18}]icos-18-ene-6,2'-oxane]-16-yl]oxyethyl]propane-1,3-diol, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CHLORIDE ION, ... | Authors: | Liu, S, Chang, S, Ye, S, Bai, X, Guo, J. | Deposit date: | 2019-07-27 | Release date: | 2019-10-23 | Last modified: | 2020-07-29 | Method: | ELECTRON MICROSCOPY (3.5 Å) | Cite: | Cryo-EM structures of the human cation-chloride cotransporter KCC1. Science, 366, 2019
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