8XOK

Cryo-EM structure of human ABCC4

Summary for 8XOK

Entry DOI	10.2210/pdb8xok/pdb
EMDB information	38532
Descriptor	ATP-binding cassette sub-family C member 4, 2-[2-[(1~{S},2~{S},4~{S},5'~{R},6~{R},7~{S},8~{R},9~{S},12~{S},13~{R},16~{S})-5',7,9,13-tetramethylspiro[5-oxapentacyclo[10.8.0.0^{2,9}.0^{4,8}.0^{13,18}]icos-18-ene-6,2'-oxane]-16-yl]oxyethyl]propane-1,3-diol, PALMITIC ACID (3 entities in total)
Functional Keywords	abc transporter mrp, transport protein
Biological source	Homo sapiens (human)
Total number of polymer chains	1
Total formula weight	157184.87
Authors	Zhang, P.F.,Liu, Z. (deposition date: 2024-01-01, release date: 2024-07-24)
Primary citation	Zhu, Y.,Xing, X.,Wang, F.,Chen, L.,Zhong, C.,Lu, X.,Yu, Z.,Yang, Y.,Yao, Y.,Song, Q.,Han, S.,Liu, Z.,Zhang, P. The ATP-bound inward-open conformation of ABCC4 reveals asymmetric ATP binding for substrate transport. Febs Lett., 2024 Cited by PubMed: 38886124 DOI: 10.1002/1873-3468.14955 PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (2.84 Å)

Structure validation