8UV2
Human p97/VCP structure with a triazole inhibitor (NSC799462/hexamer)
Summary for 8UV2
Entry DOI | 10.2210/pdb8uv2/pdb |
EMDB information | 42603 |
Descriptor | Transitional endoplasmic reticulum ATPase, ADENOSINE-5'-DIPHOSPHATE, 3-(2,6-difluoro-4-{[(4P)-5-{[(2S)-hexan-2-yl]sulfanyl}-4-(pyridin-3-yl)-4H-1,2,4-triazol-3-yl]methoxy}phenyl)prop-2-yn-1-yl (1-methylpiperidin-4-yl)carbamate (3 entities in total) |
Functional Keywords | aaa+ atpase, p97, vcp, triazole, allosteric inhibition, motor protein |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 6 |
Total formula weight | 545339.57 |
Authors | |
Primary citation | Nandi, P.,DeVore, K.,Wang, F.,Li, S.,Walker, J.D.,Truong, T.T.,LaPorte, M.G.,Wipf, P.,Schlager, H.,McCleerey, J.,Paquette, W.,Columbres, R.C.A.,Gan, T.,Poh, Y.P.,Fromme, P.,Flint, A.J.,Wolf, M.,Huryn, D.M.,Chou, T.F.,Chiu, P.L. Mechanism of allosteric inhibition of human p97/VCP ATPase and its disease mutant by triazole inhibitors. Commun Chem, 7:177-177, 2024 Cited by PubMed: 39122922DOI: 10.1038/s42004-024-01267-3 PDB entries with the same primary citation |
Experimental method | ELECTRON MICROSCOPY (3.23 Å) |
Structure validation
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