8W78
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![BU of 8w78 by Molmil](/molmil-images/mine/8w78) | Structure of Drosophila melanogaster L-2-hydroxyglutarate dehydrogenase in complex with FAD and 2-oxoglutarate | Descriptor: | 2-OXOGLUTARIC ACID, DODECYL-BETA-D-MALTOSIDE, FI05204p, ... | Authors: | Yang, J, Chen, X, Jin, S, Ding, J. | Deposit date: | 2023-08-30 | Release date: | 2023-11-29 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (2.81 Å) | Cite: | Structure and biochemical characterization of l-2-hydroxyglutarate dehydrogenase and its role in the pathogenesis of l-2-hydroxyglutaric aciduria. J.Biol.Chem., 300, 2023
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8W75
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![BU of 8w75 by Molmil](/molmil-images/mine/8w75) | Structure of Drosophila melanogaster L-2-hydroxyglutarate dehydrogenase | Descriptor: | DODECYL-BETA-D-MALTOSIDE, FI05204p, FLAVIN-ADENINE DINUCLEOTIDE | Authors: | Yang, J, Chen, X, Jin, S, Ding, J. | Deposit date: | 2023-08-30 | Release date: | 2023-11-29 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (2.85 Å) | Cite: | Structure and biochemical characterization of l-2-hydroxyglutarate dehydrogenase and its role in the pathogenesis of l-2-hydroxyglutaric aciduria. J.Biol.Chem., 300, 2023
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8W7F
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![BU of 8w7f by Molmil](/molmil-images/mine/8w7f) | Structure of Drosophila melanogaster L-2-hydroxyglutarate dehydrogenase bound with FAD and a sulfate ion | Descriptor: | DODECYL-BETA-D-MALTOSIDE, FI05204p, FLAVIN-ADENINE DINUCLEOTIDE, ... | Authors: | Yang, J, Chen, X, Jin, S, Ding, J. | Deposit date: | 2023-08-30 | Release date: | 2023-11-29 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (2.299 Å) | Cite: | Structure and biochemical characterization of l-2-hydroxyglutarate dehydrogenase and its role in the pathogenesis of l-2-hydroxyglutaric aciduria. J.Biol.Chem., 300, 2023
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5Y4S
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![BU of 5y4s by Molmil](/molmil-images/mine/5y4s) | Structure of a methyltransferase complex | Descriptor: | Chemotaxis protein methyltransferase 1 | Authors: | Yan, X, Xin, L, Tan, Y.J, Jin, S, Liang, Z.X, Gao, Y.G. | Deposit date: | 2017-08-04 | Release date: | 2017-11-29 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (3.405 Å) | Cite: | Structural analyses unravel the molecular mechanism of cyclic di-GMP regulation of bacterial chemotaxis via a PilZ adaptor protein. J. Biol. Chem., 293, 2018
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5Y4R
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![BU of 5y4r by Molmil](/molmil-images/mine/5y4r) | Structure of a methyltransferase complex | Descriptor: | 9,9'-[(2R,3R,3aS,5S,7aR,9R,10R,10aS,12S,14aR)-3,5,10,12-tetrahydroxy-5,12-dioxidooctahydro-2H,7H-difuro[3,2-d:3',2'-j][1,3,7,9,2,8]tetraoxadiphosphacyclododecine-2,9-diyl]bis(2-amino-1,9-dihydro-6H-purin-6-one), Chemotaxis protein methyltransferase 1, Cyclic diguanosine monophosphate-binding protein PA4608, ... | Authors: | Yan, X, Xin, L, Tan, Y.J, Jin, S, Liang, Z.X, Gao, Y.G. | Deposit date: | 2017-08-04 | Release date: | 2017-11-29 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2.298 Å) | Cite: | Structural analyses unravel the molecular mechanism of cyclic di-GMP regulation of bacterial chemotaxis via a PilZ adaptor protein. J. Biol. Chem., 293, 2018
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7C3M
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![BU of 7c3m by Molmil](/molmil-images/mine/7c3m) | Structure of FERM protein | Descriptor: | Fermitin family homolog 3,Fermitin family homolog 3,Fermitin family homolog 3 | Authors: | Bu, W, Loh, Z.Y, Jin, S, Basu, S, Ero, R, Park, J.E, Yan, X, Wang, M, Sze, S.K, Tan, S.M, Gao, Y.G. | Deposit date: | 2020-05-13 | Release date: | 2020-06-03 | Last modified: | 2024-03-27 | Method: | X-RAY DIFFRACTION (3.6 Å) | Cite: | Structural basis of human full-length kindlin-3 homotrimer in an auto-inhibited state. Plos Biol., 18, 2020
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7D7D
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![BU of 7d7d by Molmil](/molmil-images/mine/7d7d) | CryoEM structure of gp45-dependent transcription activation complex | Descriptor: | DNA (nontemplate strand), DNA (template strand), DNA polymerase clamp, ... | Authors: | Shi, J, Wen, A, Jin, S, Feng, Y. | Deposit date: | 2020-10-03 | Release date: | 2021-01-20 | Last modified: | 2024-03-27 | Method: | ELECTRON MICROSCOPY (4.5 Å) | Cite: | Transcription activation by a sliding clamp. Nat Commun, 12, 2021
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7D7C
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![BU of 7d7c by Molmil](/molmil-images/mine/7d7c) | CryoEM structure of gp55-dependent RNA polymerase-promoter open complex | Descriptor: | DNA (nontemplate strand), DNA (template strand), DNA-directed RNA polymerase subunit alpha, ... | Authors: | Shi, J, Wen, A, Jin, S, Feng, Y. | Deposit date: | 2020-10-03 | Release date: | 2021-01-20 | Last modified: | 2024-03-27 | Method: | ELECTRON MICROSCOPY (3.6 Å) | Cite: | Transcription activation by a sliding clamp. Nat Commun, 12, 2021
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2WO4
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![BU of 2wo4 by Molmil](/molmil-images/mine/2wo4) | 3b' carbohydrate-binding module from the Cel9V glycoside hydrolase from Clostridium thermocellum, in-house data | Descriptor: | CALCIUM ION, CHLORIDE ION, GLYCOSIDE HYDROLASE, ... | Authors: | Petkun, S, Jindou, S, Shimon, L.J.W, Bayer, E.A, Lamed, R, Frolow, F. | Deposit date: | 2009-07-21 | Release date: | 2009-12-29 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (1.85 Å) | Cite: | Structure of a Family 3B' Carbohydrate-Binding Module from the Cel9V Glycoside Hydrolase from Clostridium Thermocellum: Structural Diversity and Implications for Carbohydrate Binding Acta Crystallogr.,Sect.D, 66, 2010
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2WNX
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![BU of 2wnx by Molmil](/molmil-images/mine/2wnx) | 3b' carbohydrate-binding module from the Cel9V glycoside hydrolase from Clostridium thermocellum | Descriptor: | CALCIUM ION, FORMIC ACID, GLYCOSIDE HYDROLASE, ... | Authors: | Petkun, S, Jindou, S, Shimon, L.J.W, Bayer, E.A, Lamed, R, Frolow, F. | Deposit date: | 2009-07-20 | Release date: | 2009-12-29 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (1.31 Å) | Cite: | Structure of a Family 3B' Carbohydrate-Binding Module from the Cel9V Glycoside Hydrolase from Clostridium Thermocellum: Structural Diversity and Implications for Carbohydrate Binding Acta Crystallogr.,Sect.D, 66, 2010
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2WOB
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![BU of 2wob by Molmil](/molmil-images/mine/2wob) | 3b' carbohydrate-binding module from the Cel9V glycoside hydrolase from Clostridium thermocellum. Orthorhombic structure | Descriptor: | CALCIUM ION, GLYCOSIDE HYDROLASE, FAMILY 9 | Authors: | Petkun, S, Jindou, S, Shimon, L.J.W, Bayer, E.A, Lamed, R, Frolow, F. | Deposit date: | 2009-07-22 | Release date: | 2009-12-29 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Structure of a Family 3B' Carbohydrate-Binding Module from the Cel9V Glycoside Hydrolase from Clostridium Thermocellum: Structural Diversity and Implications for Carbohydrate Binding Acta Crystallogr.,Sect.D, 66, 2010
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2XFG
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![BU of 2xfg by Molmil](/molmil-images/mine/2xfg) | Reassembly and co-crystallization of a family 9 processive endoglucanase from separately expressed GH9 and CBM3c modules | Descriptor: | CALCIUM ION, CHLORIDE ION, ENDOGLUCANASE 1 | Authors: | Petkun, S, Lamed, R, Jindou, S, Burstein, T, Yaniv, O, Shoham, Y, Shimon, J.W.L, Bayer, E.A, Frolow, F. | Deposit date: | 2010-05-24 | Release date: | 2011-06-22 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (1.679 Å) | Cite: | Reassembly and Co-Crystallization of a Family 9 Processive Endoglucanase from its Component Parts: Structural and Functional Significance of Intermodular Linker Peerj, 3, 2015
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5XF0
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![BU of 5xf0 by Molmil](/molmil-images/mine/5xf0) | |
8WMD
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![BU of 8wmd by Molmil](/molmil-images/mine/8wmd) | Structure of the SARS-CoV-2 EG.5.1 spike glycoprotein (closed-2 state) | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein | Authors: | Nomai, T, Anraku, Y, Kita, S, Hashiguchi, T, Maenaka, K. | Deposit date: | 2023-10-03 | Release date: | 2024-04-24 | Last modified: | 2024-07-17 | Method: | ELECTRON MICROSCOPY (2.71 Å) | Cite: | Virological characteristics of the SARS-CoV-2 Omicron EG.5.1 variant. Microbiol Immunol, 2024
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8WMF
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![BU of 8wmf by Molmil](/molmil-images/mine/8wmf) | Structure of the SARS-CoV-2 EG.5.1 spike glycoprotein (closed-1 state) | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein | Authors: | Nomai, T, Anraku, Y, Kita, S, Hashiguchi, T, Maenaka, K. | Deposit date: | 2023-10-03 | Release date: | 2024-04-24 | Last modified: | 2024-07-17 | Method: | ELECTRON MICROSCOPY (2.51 Å) | Cite: | Virological characteristics of the SARS-CoV-2 Omicron EG.5.1 variant. Microbiol Immunol, 2024
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8XLM
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![BU of 8xlm by Molmil](/molmil-images/mine/8xlm) | Structure of the SARS-CoV-2 EG.5.1 spike glycoprotein in complex with ACE2 (1-up state) | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Processed angiotensin-converting enzyme 2, ... | Authors: | Nomai, T, Anraku, Y, Kita, S, Hashiguchi, T, Maenaka, K. | Deposit date: | 2023-12-26 | Release date: | 2024-05-01 | Last modified: | 2024-07-17 | Method: | ELECTRON MICROSCOPY (3.22 Å) | Cite: | Virological characteristics of the SARS-CoV-2 Omicron EG.5.1 variant. Microbiol Immunol, 2024
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8XLN
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![BU of 8xln by Molmil](/molmil-images/mine/8xln) | Structure of the SARS-CoV-2 EG.5.1 spike RBD in complex with ACE2 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Processed angiotensin-converting enzyme 2, ... | Authors: | Nomai, T, Anraku, Y, Kita, S, Hashiguchi, T, Maenaka, K. | Deposit date: | 2023-12-26 | Release date: | 2024-05-01 | Last modified: | 2024-07-17 | Method: | ELECTRON MICROSCOPY (3.78 Å) | Cite: | Virological characteristics of the SARS-CoV-2 Omicron EG.5.1 variant. Microbiol Immunol, 2024
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8COH
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![BU of 8coh by Molmil](/molmil-images/mine/8coh) | Structure of the complement C5 specific nanobody TPP-3444 | Descriptor: | CITRIC ACID, MANGANESE (II) ION, Nanobody TPP-3444 | Authors: | Pedersen, D.V, Andersen, G.R. | Deposit date: | 2023-02-28 | Release date: | 2024-01-03 | Method: | X-RAY DIFFRACTION (1.3 Å) | Cite: | Characterization of the bispecific VHH antibody gefurulimab (ALXN1720) targeting complement component 5, and designed for low volume subcutaneous administration. Mol.Immunol., 165, 2023
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8COE
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![BU of 8coe by Molmil](/molmil-images/mine/8coe) | complement C5 in complex with the LCP0195 nanobody | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Complement C5 alpha chain, Complement C5 beta chain, ... | Authors: | Andersen, G.R, Pedersen, D.V. | Deposit date: | 2023-02-28 | Release date: | 2024-01-03 | Method: | X-RAY DIFFRACTION (4.2 Å) | Cite: | Characterization of the bispecific VHH antibody gefurulimab (ALXN1720) targeting complement component 5, and designed for low volume subcutaneous administration. Mol.Immunol., 165, 2023
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8IU1
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![BU of 8iu1 by Molmil](/molmil-images/mine/8iu1) | Crystal structure of mouse Galectin-3 in complex with small molecule inhibitor | Descriptor: | 2-[(2R,3R,4S,5R,6R)-2-(3,4-dichlorophenyl)sulfanyl-6-(hydroxymethyl)-5-oxidanyl-4-[4-[3,4,5-tris(fluoranyl)phenyl]-1,2,3-triazol-1-yl]oxan-3-yl]oxyethanoic acid, Galectin-3, MAGNESIUM ION | Authors: | Jinal, S, Amit, K, Ghosh, K. | Deposit date: | 2023-03-23 | Release date: | 2024-03-27 | Method: | X-RAY DIFFRACTION (1.97 Å) | Cite: | Discovery and Exploration of Monosaccharide Linked Dimers to Target Fibrosis To Be Published
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8ITZ
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![BU of 8itz by Molmil](/molmil-images/mine/8itz) | Crystal structure of human Galectin-3 in complex with small molecule inhibitor | Descriptor: | 2-[(2R,3R,4S,5R,6R)-2-(3,4-dichlorophenyl)sulfanyl-6-(hydroxymethyl)-5-oxidanyl-4-[4-[3,4,5-tris(fluoranyl)phenyl]-1,2,3-triazol-1-yl]oxan-3-yl]oxyethanoic acid, CHLORIDE ION, Galectin-3, ... | Authors: | Jinal, S, Amit, K, Ghosh, K. | Deposit date: | 2023-03-23 | Release date: | 2024-03-27 | Method: | X-RAY DIFFRACTION (1.22 Å) | Cite: | Discovery and Exploration of Monosaccharide Linked Dimers to Target Fibrosis To Be Published
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8ITX
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![BU of 8itx by Molmil](/molmil-images/mine/8itx) | Crystal structure of human Galectin-3 in complex with small molecule inhibitor | Descriptor: | 2-[(2S,3R,4S,5R,6R)-2-[2-[2,5-bis(chloranyl)phenyl]-5-methyl-1,2,4-triazol-3-yl]-4-[4-[4-chloranyl-3,5-bis(fluoranyl)phenyl]-1,2,3-triazol-1-yl]-6-(hydroxymethyl)-5-oxidanyl-oxan-3-yl]oxyethanoic acid, CHLORIDE ION, Galectin-3, ... | Authors: | Jinal, S, Ghosh, K. | Deposit date: | 2023-03-23 | Release date: | 2024-03-27 | Method: | X-RAY DIFFRACTION (1.12 Å) | Cite: | Discovery and Exploration of Monosaccharide Linked Dimers to Target Fibrosis To Be Published
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3ZC6
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![BU of 3zc6 by Molmil](/molmil-images/mine/3zc6) | Crystal structure of JAK3 kinase domain in complex with an indazole substituted pyrrolopyrazine inhibitor | Descriptor: | CHLORIDE ION, DI(HYDROXYETHYL)ETHER, N-[(2R)-1-(3-cyanoazetidin-1-yl)-1-oxidanylidene-propan-2-yl]-2-(6-fluoranyl-1-methyl-indazol-3-yl)-5H-pyrrolo[2,3-b]pyrazine-7-carboxamide, ... | Authors: | Kuglstatter, A, Jestel, A, Nagel, S, Boettcher, J, Blaesse, M. | Deposit date: | 2012-11-16 | Release date: | 2013-09-25 | Method: | X-RAY DIFFRACTION (2.42 Å) | Cite: | Strategic Use of Conformational Bias and Structure Based Design to Identify Potent Jak3 Inhibitors with Improved Selectivity Against the Jak Family and the Kinome. Bioorg.Med.Chem.Lett., 23, 2013
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3ZEP
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![BU of 3zep by Molmil](/molmil-images/mine/3zep) | Crystal Structure of JAK3 Kinase Domain in Complex with a Pyrrolopyrazine-2-phenyl Ether Inhibitor | Descriptor: | 2-[[(3R)-3-acetamido-2,3-dihydro-1H-inden-5-yl]oxy]-N-[(1S)-1-cyclopropylethyl]-5H-pyrrolo[2,3-b]pyrazine-7-carboxamide, GLYCEROL, TYROSINE-PROTEIN KINASE JAK3 | Authors: | Kuglstatter, A, Jestel, A, Nagel, S, Boettcher, J, Blaesse, M. | Deposit date: | 2012-12-06 | Release date: | 2013-12-11 | Last modified: | 2016-09-14 | Method: | X-RAY DIFFRACTION (2.35 Å) | Cite: | Discovery of a Series of Novel 5H-Pyrrolo[2,3-B]Pyrazine-2-Phenyl Ethers, as Potent Jak3 Kinase Inhibitors. Bioorg.Med.Chem.Lett., 23, 2013
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5I95
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![BU of 5i95 by Molmil](/molmil-images/mine/5i95) | Crystal Structure of Human Mitochondrial Isocitrate Dehydrogenase R140Q Mutant Homodimer bound to NADPH and alpha-Ketoglutaric acid | Descriptor: | 2-OXOGLUTARIC ACID, ACETATE ION, CALCIUM ION, ... | Authors: | Zhang, B, Jin, L, Wu, W, Jiang, F, DeLaBarre, B, Travins, J.A, Padyana, A.K. | Deposit date: | 2016-02-19 | Release date: | 2017-03-01 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (1.54 Å) | Cite: | AG-221, a First-in-Class Therapy Targeting Acute Myeloid Leukemia Harboring Oncogenic IDH2 Mutations. Cancer Discov, 7, 2017
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