8ITZ

Crystal structure of human Galectin-3 in complex with small molecule inhibitor

Summary for 8ITZ

• Entry DOI: 10.2210/pdb8itz/pdb
• Descriptor: Galectin-3, CHLORIDE ION, 2-[(2R,3R,4S,5R,6R)-2-(3,4-dichlorophenyl)sulfanyl-6-(hydroxymethyl)-5-oxidanyl-4-[4-[3,4,5-tris(fluoranyl)phenyl]-1,2,3-triazol-1-yl]oxan-3-yl]oxyethanoic acid, ... (5 entities in total)
• Functional Keywords: fibrosis, galactose, sugar binding protein
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 1
• Total formula weight: 19986.79

Authors

Jinal, S.,Amit, K.,Ghosh, K. (deposition date: 2023-03-23, release date: 2024-03-27)

• Primary citation: Swidorski, J.J.,Beno, B.B.,Liu, C.,Yoon, D.,Ghosh, K.,Sale, H.,Shah, D.,Acharya, K.,Yanchunas, J.,Ellsworth, B.,Cheng, D.,Regueiro-Ren, A.; Discovery and Exploration of Monosaccharide Linked Dimers to Target Fibrosis; To Be Published,

Experimental method

X-RAY DIFFRACTION (1.22 Å)