8ITX

Crystal structure of human Galectin-3 in complex with small molecule inhibitor

Summary for 8ITX

• Entry DOI: 10.2210/pdb8itx/pdb
• Descriptor: Galectin-3, CHLORIDE ION, 2-[(2S,3R,4S,5R,6R)-2-[2-[2,5-bis(chloranyl)phenyl]-5-methyl-1,2,4-triazol-3-yl]-4-[4-[4-chloranyl-3,5-bis(fluoranyl)phenyl]-1,2,3-triazol-1-yl]-6-(hydroxymethyl)-5-oxidanyl-oxan-3-yl]oxyethanoic acid, ... (5 entities in total)
• Functional Keywords: fibrosis, galactose, sugar binding protein-inhibitor complex, sugar binding protein/inhibitor
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 2
• Total formula weight: 40779.35

Authors

Jinal, S.,Ghosh, K. (deposition date: 2023-03-23, release date: 2024-03-27)

• Primary citation: Swidorski, J.J.,Beno, B.B.,Liu, C.,Yoon, D.,Ghosh, K.,Sale, H.,Shah, D.,Acharya, K.,Yanchunas, J.,Ellsworth, B.,Cheng, D.,Regueiro-Ren, A.; Discovery and Exploration of Monosaccharide Linked Dimers to Target Fibrosis; To Be Published,

Experimental method

X-RAY DIFFRACTION (1.12 Å)