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7SAS
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BU of 7sas by Molmil
Cryo-EM structure of TMEM106B fibrils extracted from a FTLD-TDP patient, polymorph 3
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Transmembrane protein 106B
Authors:Cao, Q, Jiang, Y, Sawaya, M.R, Eisenberg, D.S.
Deposit date:2021-09-23
Release date:2022-03-09
Last modified:2022-05-25
Method:ELECTRON MICROSCOPY (3.7 Å)
Cite:Amyloid fibrils in FTLD-TDP are composed of TMEM106B and not TDP-43.
Nature, 605, 2022
5UQ9
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BU of 5uq9 by Molmil
Crystal structure of 6-phosphogluconate dehydrogenase with ((4R,5R)-5-(hydroxycarbamoyl)-2,2-dimethyl-1,3-dioxolan-4-yl)methyl dihydrogen phosphate
Descriptor: 6-phosphogluconate dehydrogenase, decarboxylating, [(4R,5R)-5-(hydroxycarbamoyl)-2,2-dimethyl-1,3-dioxolan-4-yl]methyl dihydrogen phosphate
Authors:Leonard, P.G.
Deposit date:2017-02-07
Release date:2018-08-22
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (3 Å)
Cite:Functional Genomics Reveals Synthetic Lethality between Phosphogluconate Dehydrogenase and Oxidative Phosphorylation.
Cell Rep, 26, 2019
8GTD
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BU of 8gtd by Molmil
Cryo-EM model of the marine siphophage vB_DshS-R4C portal-adaptor complex
Descriptor: Head-to-tail joining protein, Portal protein
Authors:Huang, Y, Sun, H, Wei, S, Zheng, Q, Li, S, Zhang, R, Xia, N.
Deposit date:2022-09-08
Release date:2023-07-12
Last modified:2024-06-19
Method:ELECTRON MICROSCOPY (4.7 Å)
Cite:Structure and proposed DNA delivery mechanism of a marine roseophage.
Nat Commun, 14, 2023
8GTA
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BU of 8gta by Molmil
Cryo-EM structure of the marine siphophage vB_Dshs-R4C capsid
Descriptor: Major capsid protein
Authors:Sun, H, Huang, Y, Zheng, Q, Li, S, Zhang, R, Xia, N.
Deposit date:2022-09-07
Release date:2023-07-12
Last modified:2023-08-16
Method:ELECTRON MICROSCOPY (3.63 Å)
Cite:Structure and proposed DNA delivery mechanism of a marine roseophage.
Nat Commun, 14, 2023
8GTF
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BU of 8gtf by Molmil
Cryo-EM model of the marine siphophage vB_DshS-R4C stopper-terminator complex
Descriptor: Head-to-tail joining protein, Major tail protein, Terminator protein
Authors:Huang, Y, Sun, H, Wei, S, Zheng, Q, Li, S, Zhang, R, Xia, N.
Deposit date:2022-09-08
Release date:2023-07-12
Last modified:2024-06-19
Method:ELECTRON MICROSCOPY (6.6 Å)
Cite:Structure and proposed DNA delivery mechanism of a marine roseophage.
Nat Commun, 14, 2023
8GTB
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BU of 8gtb by Molmil
Cryo-EM structure of the marine siphophage vB_DshS-R4C tail tube protein
Descriptor: Major tail protein
Authors:Huang, Y, Sun, H, Wei, S, Zheng, Q, Li, S, Zhang, R, Xia, N.
Deposit date:2022-09-08
Release date:2023-07-12
Last modified:2024-06-19
Method:ELECTRON MICROSCOPY (3.43 Å)
Cite:Structure and proposed DNA delivery mechanism of a marine roseophage.
Nat Commun, 14, 2023
8GTC
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BU of 8gtc by Molmil
Cryo-EM model of the marine siphophage vB_DshS-R4C baseplate-tail complex
Descriptor: Distal tail protein, Hub protein, Major tail protein, ...
Authors:Huang, Y, Sun, H, Wei, S, Zheng, Q, Li, S, Zhang, R, Xia, N.
Deposit date:2022-09-08
Release date:2023-07-12
Last modified:2024-06-19
Method:ELECTRON MICROSCOPY (4.5 Å)
Cite:Structure and proposed DNA delivery mechanism of a marine roseophage.
Nat Commun, 14, 2023
5H7V
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BU of 5h7v by Molmil
Structure of full-length extracellular domain of HAI-1 at pH 4.6
Descriptor: Kunitz-type protease inhibitor 1
Authors:Liu, M, Huang, M.
Deposit date:2016-11-21
Release date:2017-03-29
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (3.82 Å)
Cite:The crystal structure of a multidomain protease inhibitor (HAI-1) reveals the mechanism of its auto-inhibition
J. Biol. Chem., 292, 2017
3HI4
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BU of 3hi4 by Molmil
Switching catalysis from hydrolysis to perhydrolysis in P. fluorescens esterase
Descriptor: ACETATE ION, Arylesterase, GLYCEROL, ...
Authors:Purpero, V.M.
Deposit date:2009-05-18
Release date:2010-02-23
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:Switching catalysis from hydrolysis to perhydrolysis in Pseudomonas fluorescens esterase.
Biochemistry, 49, 2010
3HEA
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BU of 3hea by Molmil
The L29P/L124I mutation of Pseudomonas fluorescens esterase
Descriptor: Arylesterase, ETHYL ACETATE, GLYCEROL, ...
Authors:Kazlauskas, R.J, Schrag, J.D, Cheeseman, J.D, Morley, K.L.
Deposit date:2009-05-08
Release date:2010-03-23
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Switching catalysis from hydrolysis to perhydrolysis in Pseudomonas fluorescens esterase.
Biochemistry, 49, 2010
6A4M
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BU of 6a4m by Molmil
Structure of urate oxidase from Bacillus subtilis 168
Descriptor: GLYCEROL, Uric acid degradation bifunctional protein PucL
Authors:Jiang, Y.Y.
Deposit date:2018-06-20
Release date:2019-06-26
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Crystal Structure of Urate Oxidase from Bacillus Subtilis 168
Crystallography Reports, 64, 2019
6L3F
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BU of 6l3f by Molmil
The structure of UTP:RNA uridylyltransferase 1 (URT1) in in Arabidopsis
Descriptor: UTP:RNA uridylyltransferase 1
Authors:Lingru, Z.
Deposit date:2019-10-10
Release date:2020-01-29
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (1.975 Å)
Cite:Crystal structure of Arabidopsis terminal uridylyl transferase URT1.
Biochem.Biophys.Res.Commun., 524, 2020
6L8K
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BU of 6l8k by Molmil
Structure of URT1 in complex with UTP
Descriptor: URIDINE 5'-TRIPHOSPHATE, UTP:RNA uridylyltransferase 1
Authors:Lingru, Z.
Deposit date:2019-11-06
Release date:2020-01-29
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (2.999 Å)
Cite:Crystal structure of Arabidopsis terminal uridylyl transferase URT1.
Biochem.Biophys.Res.Commun., 524, 2020
5YYF
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BU of 5yyf by Molmil
Crystal structure of AF9 YEATS domain in complex with a peptide inhibitor "PHQ-H3(Q5-K9)" modified at K9 with 2-furancarboyl group
Descriptor: 2-FUROIC ACID, Peptide inhibitor PHQ-H3(Q5-K9), Protein AF-9, ...
Authors:Li, Y, Li, H.
Deposit date:2017-12-09
Release date:2018-11-07
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (1.903 Å)
Cite:Structure-guided development of YEATS domain inhibitors by targeting pi-pi-pi stacking.
Nat. Chem. Biol., 14, 2018
3TYQ
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BU of 3tyq by Molmil
SAR development and discovery of potent indole-based inhibitors of the hepatitis c virus NS5B polymerase
Descriptor: 5-ethyl-1-(2-fluoro-5-nitrobenzyl)-3-(2-oxo-1,2-dihydropyridin-3-yl)-1H-indole-2-carboxylic acid, PHOSPHATE ION, RNA-directed RNA polymerase
Authors:Lesburg, C.A, Chen, K.X.
Deposit date:2011-09-26
Release date:2012-02-01
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:A Novel Class of Highly Potent Irreversible Hepatitis C Virus NS5B Polymerase Inhibitors.
J.Med.Chem., 55, 2012
3TYV
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BU of 3tyv by Molmil
SAR development and discovery of potent indole-based inhibitors of the hepatitis C virus NS5B polymerase
Descriptor: N-(cyclopropylsulfonyl)-1-(2,5-difluorobenzyl)-6-fluoro-5-methyl-3-(2-oxo-1,2-dihydropyridin-3-yl)-1H-indole-2-carboxamide, PHOSPHATE ION, RNA-directed RNA polymerase
Authors:Lesburg, C.A, Chen, K.X.
Deposit date:2011-09-26
Release date:2012-02-01
Last modified:2024-03-06
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:Structure-Activity Relationship (SAR) Development and Discovery of Potent Indole-Based Inhibitors of the Hepatitis C Virus (HCV) NS5B Polymerase.
J.Med.Chem., 55, 2012
5ZI6
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BU of 5zi6 by Molmil
The RING domain structure of MEX-3C
Descriptor: RNA-binding E3 ubiquitin-protein ligase MEX3C, ZINC ION
Authors:Moududee, S.A, Tang, Y.
Deposit date:2018-03-14
Release date:2018-10-24
Last modified:2024-03-27
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structural and functional characterization of hMEX-3C Ring finger domain as an E3 ubiquitin ligase
Protein Sci., 27, 2018
8FLU
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BU of 8flu by Molmil
Human PTH1R in complex with LA-PTH and Gs
Descriptor: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(s) subunit alpha isoforms short, ...
Authors:Cary, B.P, Belousoff, M.J, Piper, S.J, Wootten, D, Sexton, P.M.
Deposit date:2022-12-22
Release date:2023-04-26
Last modified:2023-06-14
Method:ELECTRON MICROSCOPY (2.76 Å)
Cite:Molecular insights into peptide agonist engagement with the PTH receptor.
Structure, 31, 2023
8FLR
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BU of 8flr by Molmil
Human PTH1R in complex with PTHrP and Gs
Descriptor: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(s) subunit alpha isoforms short, ...
Authors:Cary, B.P, Belousoff, M.J, Piper, S.J, Wootten, D, Sexton, P.M.
Deposit date:2022-12-22
Release date:2023-04-26
Last modified:2023-06-14
Method:ELECTRON MICROSCOPY (2.94 Å)
Cite:Molecular insights into peptide agonist engagement with the PTH receptor.
Structure, 31, 2023
8FLT
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BU of 8flt by Molmil
Human PTH1R in complex with M-PTH(1-14) and Gs
Descriptor: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(s) subunit alpha isoforms short, ...
Authors:Cary, B.P, Belousoff, M.J, Piper, S.J, Wootten, D, Sexton, P.M.
Deposit date:2022-12-22
Release date:2023-04-26
Last modified:2023-06-14
Method:ELECTRON MICROSCOPY (3.03 Å)
Cite:Molecular insights into peptide agonist engagement with the PTH receptor.
Structure, 31, 2023
8FLQ
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BU of 8flq by Molmil
Human PTH1R in complex with PTH(1-34) and Gs
Descriptor: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(s) subunit alpha isoforms short, ...
Authors:Cary, B.P, Belousoff, M.J, Piper, S.J, Wootten, D, Sexton, P.M.
Deposit date:2022-12-22
Release date:2023-04-26
Last modified:2023-06-14
Method:ELECTRON MICROSCOPY (2.55 Å)
Cite:Molecular insights into peptide agonist engagement with the PTH receptor.
Structure, 31, 2023
8FLS
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BU of 8fls by Molmil
Human PTH1R in complex with Abaloparatide and Gs
Descriptor: Abaloparatide, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ...
Authors:Cary, B.P, Belousoff, M.J, Piper, S.J, Wootten, D, Sexton, P.M.
Deposit date:2022-12-22
Release date:2023-04-26
Last modified:2023-06-14
Method:ELECTRON MICROSCOPY (3.09 Å)
Cite:Molecular insights into peptide agonist engagement with the PTH receptor.
Structure, 31, 2023
8SKQ
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BU of 8skq by Molmil
RNA oligonucleotide containing an alpha-(L)-threofuranosyl nucleic acid (TNA)
Descriptor: TNA-containing RNA oligonucleotide
Authors:Harp, J.M, Egli, M.
Deposit date:2023-04-20
Release date:2024-02-14
Method:X-RAY DIFFRACTION (1.35 Å)
Cite:Shorter Is Better: The alpha-(l)-Threofuranosyl Nucleic Acid Modification Improves Stability, Potency, Safety, and Ago2 Binding and Mitigates Off-Target Effects of Small Interfering RNAs.
J.Am.Chem.Soc., 145, 2023
5Y0U
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BU of 5y0u by Molmil
The solution structure of AEBP2 C2H2 zinc fingers
Descriptor: ZINC ION, Zinc finger protein AEBP2
Authors:Sun, A, Shi, Y, Wu, J.
Deposit date:2017-07-18
Release date:2018-08-01
Last modified:2024-05-15
Method:SOLUTION NMR
Cite:Structural and biochemical insights into human zinc finger protein AEBP2 reveals interactions with RBBP4.
Protein Cell, 9, 2018
6ASG
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BU of 6asg by Molmil
Crystal structure of Thermus thermophilus RNA polymerase core enzyme
Descriptor: DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ...
Authors:Liu, Y, Lin, W, Ying, R, Ebright, R.H.
Deposit date:2017-08-24
Release date:2018-04-11
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (3.8 Å)
Cite:Structural Basis of Transcription Inhibition by Fidaxomicin (Lipiarmycin A3).
Mol. Cell, 70, 2018

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數據於2024-06-26公開中

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