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7LUZ
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BU of 7luz by Molmil
GQTVTK segment from the Nucleoprotein of SARS-CoV-2, residues 243-248
Descriptor: Nucleoprotein GQTVTK
Authors:Balbirnie, M, Sawaya, M.R, Eisenberg, D.S, Cascio, D.
Deposit date:2021-02-23
Release date:2021-03-17
Last modified:2024-03-06
Method:X-RAY DIFFRACTION (1.101 Å)
Cite:Inhibition of amyloid formation of the Nucleoprotein of SARS-CoV-2.
Biorxiv, 2021
7LV2
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BU of 7lv2 by Molmil
GSQASS segment from the Nucleoprotein of SARS-CoV-2, residues 179-184
Descriptor: Nucleoprotein GSQASS
Authors:Hou, K, Sawaya, M.R, Eisenberg, D.S, Cascio, D.
Deposit date:2021-02-23
Release date:2021-03-17
Last modified:2024-04-03
Method:X-RAY DIFFRACTION (1.301 Å)
Cite:Inhibition of amyloid formation of the Nucleoprotein of SARS-CoV-2.
Biorxiv, 2021
6M0K
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BU of 6m0k by Molmil
The crystal structure of COVID-19 main protease in complex with an inhibitor 11b
Descriptor: 3C-like proteinase, DIMETHYL SULFOXIDE, ~{N}-[(2~{S})-3-(3-fluorophenyl)-1-oxidanylidene-1-[[(2~{S})-1-oxidanylidene-3-[(3~{S})-2-oxidanylidenepyrrolidin-3-yl]propan-2-yl]amino]propan-2-yl]-1~{H}-indole-2-carboxamide
Authors:Zhang, B, Zhao, Y, Jin, Z, Liu, X, Yang, H, Liu, H, Rao, Z, Jiang, H.
Deposit date:2020-02-22
Release date:2020-04-29
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (1.504 Å)
Cite:Structure-based design of antiviral drug candidates targeting the SARS-CoV-2 main protease.
Science, 368, 2020
6LZE
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BU of 6lze by Molmil
The crystal structure of COVID-19 main protease in complex with an inhibitor 11a
Descriptor: 3C-like proteinase, DIMETHYL SULFOXIDE, ~{N}-[(2~{S})-3-cyclohexyl-1-oxidanylidene-1-[[(2~{S})-1-oxidanylidene-3-[(3~{S})-2-oxidanylidenepyrrolidin-3-yl]propan-2-yl]amino]propan-2-yl]-1~{H}-indole-2-carboxamide
Authors:Zhang, B, Zhang, Y, Jing, Z, Liu, X, Yang, H, Liu, H, Rao, Z, Jiang, H.
Deposit date:2020-02-19
Release date:2020-04-29
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (1.505 Å)
Cite:Structure-based design of antiviral drug candidates targeting the SARS-CoV-2 main protease.
Science, 368, 2020
5Z1V
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BU of 5z1v by Molmil
Crystal structure of AvrPib
Descriptor: AvrPib protein
Authors:Zhang, X, He, D, Zhao, Y.X, Taylor, I.A, Peng, Y.L, Yang, J, Liu, J.F.
Deposit date:2017-12-28
Release date:2018-09-05
Last modified:2018-10-03
Method:X-RAY DIFFRACTION (1.661 Å)
Cite:A positive-charged patch and stabilized hydrophobic core are essential for avirulence function of AvrPib in the rice blast fungus.
Plant J., 96, 2018
1CKJ
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BU of 1ckj by Molmil
CASEIN KINASE I DELTA TRUNCATION MUTANT CONTAINING RESIDUES 1-317 COMPLEX WITH BOUND TUNGSTATE
Descriptor: RECOMBINANT CASEIN KINASE I DELTA, TUNGSTATE(VI)ION
Authors:Longenecker, K.L, Roach, P.J, Hurley, T.D.
Deposit date:1995-08-25
Release date:1995-12-07
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2.46 Å)
Cite:Three-dimensional structure of mammalian casein kinase I: molecular basis for phosphate recognition.
J.Mol.Biol., 257, 1996
1CKI
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BU of 1cki by Molmil
RECOMBINANT CASEIN KINASE I DELTA TRUNCATION MUTANT CONTAINING RESIDUES 1-317
Descriptor: CASEIN KINASE I DELTA
Authors:Longenecker, K.L, Roach, P.J, Hurley, T.D.
Deposit date:1995-08-25
Release date:1995-12-07
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Three-dimensional structure of mammalian casein kinase I: molecular basis for phosphate recognition.
J.Mol.Biol., 257, 1996
2ADM
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BU of 2adm by Molmil
ADENINE-N6-DNA-METHYLTRANSFERASE TAQI
Descriptor: ADENINE-N6-DNA-METHYLTRANSFERASE TAQI, S-ADENOSYLMETHIONINE
Authors:Schluckebier, G, Saenger, W.
Deposit date:1996-07-15
Release date:1997-01-27
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Differential binding of S-adenosylmethionine S-adenosylhomocysteine and Sinefungin to the adenine-specific DNA methyltransferase M.TaqI.
J.Mol.Biol., 265, 1997
7CNB
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BU of 7cnb by Molmil
Crystal structure of Gp16 C-terminal domain from Bacillus virus phi29
Descriptor: DNA packaging protein
Authors:Ouyang, S.Y, Saeed, A.F.U.H.
Deposit date:2020-07-30
Release date:2021-03-24
Last modified:2024-03-27
Method:X-RAY DIFFRACTION (2.32 Å)
Cite:Structural Insights into gp16 ATPase in the Bacteriophage φ29 DNA Packaging Motor.
Biochemistry, 60, 2021
8FQ7
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BU of 8fq7 by Molmil
Nanobody with WIW inserted in CDR3 loop to Inhibit Growth of Alzheimer's Tau fibrils
Descriptor: GLYCEROL, Nanobody with WIW insert in CDR3 loop to target tau fibrils
Authors:Abskharon, R, Sawaya, M.R, Cascio, D.C, Eisenberg, D.S.
Deposit date:2023-01-05
Release date:2023-10-04
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:Structure-based design of nanobodies that inhibit seeding of Alzheimer's patient-extracted tau fibrils.
Proc.Natl.Acad.Sci.USA, 120, 2023
8GAP
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BU of 8gap by Molmil
Structure of LARP7 protein p65-telomerase RNA complex in telomerase
Descriptor: Telomerase La-related protein p65, Telomerase RNA, Telomerase associated protein p50, ...
Authors:Wang, Y, He, Y, Wang, Y, Yang, Y, Singh, M, Eichhorn, C.D, Zhou, Z.H, Feigon, J.
Deposit date:2023-02-23
Release date:2023-06-28
Last modified:2024-06-19
Method:ELECTRON MICROSCOPY (3.8 Å)
Cite:Structure of LARP7 Protein p65-telomerase RNA Complex in Telomerase Revealed by Cryo-EM and NMR.
J.Mol.Biol., 435, 2023
7V9M
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BU of 7v9m by Molmil
Cryo-EM structure of the GHRH-bound human GHRHR splice variant 1 complex
Descriptor: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(s) subunit alpha isoforms short, ...
Authors:Cong, Z.T, Zhou, F.L, Zhang, C, Zou, X.Y, Zhang, H.B, Wang, Y.Z, Zhou, Q.T, Cai, X.Q, Liu, Q.F, Li, J, Shao, L.J, Mao, C.Y, Wang, X, Wu, J.H, Xia, T, Zhao, L.H, Jiang, H.L, Zhang, Y, Xu, H.E, Chen, X, Yang, D.H, Wang, M.W.
Deposit date:2021-08-26
Release date:2021-10-20
Last modified:2024-06-19
Method:ELECTRON MICROSCOPY (3.29 Å)
Cite:Constitutive signal bias mediated by the human GHRHR splice variant 1.
Proc.Natl.Acad.Sci.USA, 118, 2021
7EYI
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BU of 7eyi by Molmil
Crystal structure of ZBTB7A in complex with gamma-globin -200 sequence element with C-194A mutation
Descriptor: BORIC ACID, DNA (5'-D(*AP*TP*AP*GP*GP*GP*CP*CP*CP*CP*TP*TP*CP*CP*CP*AP*AP*C)-3'), DNA (5'-D(*TP*GP*TP*TP*GP*GP*GP*AP*AP*GP*GP*GP*GP*CP*CP*CP*TP*A)-3'), ...
Authors:Yang, Y, Shi, Y.Y.
Deposit date:2021-05-31
Release date:2021-09-01
Last modified:2024-05-29
Method:X-RAY DIFFRACTION (2.401 Å)
Cite:Structural basis for human ZBTB7A action at the fetal globin promoter.
Cell Rep, 36, 2021
7E2X
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BU of 7e2x by Molmil
Apo serotonin 1A (5-HT1A) receptor-Gi protein complex
Descriptor: CHOLESTEROL, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ...
Authors:Xu, P, Huang, S, Zhang, H, Mao, C, Zhou, X.E, Shen, D.D, Jiang, Y, Zhang, Y, Xu, H.E.
Deposit date:2021-02-07
Release date:2021-04-14
Last modified:2021-04-28
Method:ELECTRON MICROSCOPY (3 Å)
Cite:Structural insights into the lipid and ligand regulation of serotonin receptors.
Nature, 592, 2021
7E33
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BU of 7e33 by Molmil
Serotonin 1E (5-HT1E) receptor-Gi protein complex
Descriptor: 3-(1-methylpiperidin-4-yl)-1H-indol-5-ol, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ...
Authors:Xu, P, Huang, S, Zhang, H, Mao, C, Zhou, X.E, Shen, D.D, Jiang, Y, Zhang, Y, Xu, H.E.
Deposit date:2021-02-07
Release date:2021-04-14
Last modified:2021-04-28
Method:ELECTRON MICROSCOPY (2.9 Å)
Cite:Structural insights into the lipid and ligand regulation of serotonin receptors.
Nature, 592, 2021
7E2Y
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BU of 7e2y by Molmil
Serotonin-bound Serotonin 1A (5-HT1A) receptor-Gi protein complex
Descriptor: CHOLESTEROL, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ...
Authors:Xu, P, Huang, S, Zhang, H, Mao, C, Zhou, X.E, Shen, D.D, Jiang, Y, Zhang, Y, Xu, H.E.
Deposit date:2021-02-07
Release date:2021-04-14
Last modified:2021-04-28
Method:ELECTRON MICROSCOPY (3 Å)
Cite:Structural insights into the lipid and ligand regulation of serotonin receptors.
Nature, 592, 2021
7E2Z
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BU of 7e2z by Molmil
Aripiprazole-bound serotonin 1A (5-HT1A) receptor-Gi protein complex
Descriptor: 7-[4-[4-[2,3-bis(chloranyl)phenyl]piperazin-1-yl]butoxy]-3,4-dihydro-1H-quinolin-2-one, CHOLESTEROL, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ...
Authors:Xu, P, Huang, S, Zhang, H, Mao, C, Zhou, X.E, Shen, D.D, Jiang, Y, Zhang, Y, Xu, H.E.
Deposit date:2021-02-07
Release date:2021-04-14
Last modified:2021-04-28
Method:ELECTRON MICROSCOPY (3.1 Å)
Cite:Structural insights into the lipid and ligand regulation of serotonin receptors.
Nature, 592, 2021
7E32
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BU of 7e32 by Molmil
Serotonin 1D (5-HT1D) receptor-Gi protein complex
Descriptor: CHOLESTEROL, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ...
Authors:Xu, P, Huang, S, Zhang, H, Mao, C, Zhou, X.E, Shen, D.D, Jiang, Y, Zhang, Y, Xu, H.E.
Deposit date:2021-02-07
Release date:2021-04-21
Last modified:2021-04-28
Method:ELECTRON MICROSCOPY (2.9 Å)
Cite:Structural insights into the lipid and ligand regulation of serotonin receptors.
Nature, 592, 2021
7XZ6
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BU of 7xz6 by Molmil
GPR119-Gs-APD668 complex
Descriptor: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(s) subunit alpha isoforms short, ...
Authors:Xu, P, Huang, S, Jiang, Y, Xu, H.E.
Deposit date:2022-06-02
Release date:2022-08-24
Last modified:2022-10-05
Method:ELECTRON MICROSCOPY (2.8 Å)
Cite:Structural identification of lysophosphatidylcholines as activating ligands for orphan receptor GPR119.
Nat.Struct.Mol.Biol., 29, 2022
7XZ5
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BU of 7xz5 by Molmil
GPR119-Gs-LPC complex
Descriptor: (4R,7R,18E)-4,7-dihydroxy-N,N,N-trimethyl-10-oxo-3,5,9-trioxa-4-phosphaheptacos-18-en-1-aminium 4-oxide, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ...
Authors:Xu, P, Huang, S, Jiang, Y, Xu, H.E.
Deposit date:2022-06-02
Release date:2022-08-24
Last modified:2022-10-05
Method:ELECTRON MICROSCOPY (3.1 Å)
Cite:Structural identification of lysophosphatidylcholines as activating ligands for orphan receptor GPR119.
Nat.Struct.Mol.Biol., 29, 2022
7WQ4
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BU of 7wq4 by Molmil
Galanin-bound galanin receptor 2 in complex with Gq
Descriptor: CHOLESTEROL, Engineered Guanine nucleotide-binding protein G(q) subunit alpha, Galanin, ...
Authors:Duan, J, Shen, D.D, Xu, H.E, Zhang, Y, Jiang, Y.
Deposit date:2022-01-24
Release date:2022-04-20
Last modified:2022-10-19
Method:ELECTRON MICROSCOPY (2.6 Å)
Cite:Molecular basis for allosteric agonism and G protein subtype selectivity of galanin receptors
Nat Commun, 13, 2022
7WQ3
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BU of 7wq3 by Molmil
Galanin-bound galanin receptor 1 in complex with Gi
Descriptor: CHOLESTEROL, Galanin, Galanin receptor type 1, ...
Authors:Duan, J, Shen, D.D, Xu, H.E, Zhang, Y, Jiang, Y.
Deposit date:2022-01-24
Release date:2022-04-20
Last modified:2022-10-19
Method:ELECTRON MICROSCOPY (2.7 Å)
Cite:Molecular basis for allosteric agonism and G protein subtype selectivity of galanin receptors
Nat Commun, 13, 2022
7VYO
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BU of 7vyo by Molmil
The structure of GdmN
Descriptor: 1,2-ETHANEDIOL, CHLORIDE ION, DI(HYDROXYETHYL)ETHER, ...
Authors:Wei, J, Zheng, J, Zhou, J, Kang, Q, Bai, L.
Deposit date:2021-11-14
Release date:2022-11-16
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:Endowing homodimeric carbamoyltransferase GdmN with iterative functions through structural characterization and mechanistic studies.
Nat Commun, 13, 2022
7VYJ
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BU of 7vyj by Molmil
The structure of GdmN in complex with carbamoyl adenylate intermediate
Descriptor: 1,2-ETHANEDIOL, 5'-O-[(S)-(carbamoyloxy)(hydroxy)phosphoryl]adenosine, DI(HYDROXYETHYL)ETHER, ...
Authors:Wei, J, Zheng, J, Zhou, J, Kang, Q, Bai, L.
Deposit date:2021-11-14
Release date:2022-11-16
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (1.98 Å)
Cite:Endowing homodimeric carbamoyltransferase GdmN with iterative functions through structural characterization and mechanistic studies.
Nat Commun, 13, 2022
7VYP
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BU of 7vyp by Molmil
The structure of GdmN complex with the natural tetrahedral intermediate, carbamoylated derivative, and AMP
Descriptor: 1,2-ETHANEDIOL, ADENOSINE MONOPHOSPHATE, FE (III) ION, ...
Authors:Wei, J, Zheng, J, Zhou, J, Kang, Q, Bai, L.
Deposit date:2021-11-15
Release date:2022-11-16
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (2.88 Å)
Cite:Endowing homodimeric carbamoyltransferase GdmN with iterative functions through structural characterization and mechanistic studies.
Nat Commun, 13, 2022

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數據於2024-06-19公開中

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