6AJI

Crystal structure of mycolic acid transporter MmpL3 from Mycobacterium smegmatis complexed with Rimonabant

Summary for 6AJI

• Entry DOI: 10.2210/pdb6aji/pdb
• Descriptor: Drug exporters of the RND superfamily-like protein,Endolysin, 5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-N-(piperidin-1-yl)-1H-pyrazole-3-carboxamide, alpha-D-glucopyranosyl 6-O-dodecyl-alpha-D-glucopyranoside, ... (4 entities in total)
• Functional Keywords: membrane protein, transporter, rnd family, cell wall biosynthesis, drug target, hydrolase
• Biological source: Mycobacterium smegmatis (strain ATCC 700084 / mc(2)155); More
• Total number of polymer chains: 1
• Total formula weight: 106383.57

Authors

Zhang, B.,Li, J.,Yang, X.L.,Wu, L.J.,Yang, H.T.,Rao, Z.H. (deposition date: 2018-08-27, release date: 2018-12-26, Last modification date: 2023-11-22)

• Primary citation: Zhang, B.,Li, J.,Yang, X.,Wu, L.,Zhang, J.,Yang, Y.,Zhao, Y.,Zhang, L.,Yang, X.,Yang, X.,Cheng, X.,Liu, Z.,Jiang, B.,Jiang, H.,Guddat, L.W.,Yang, H.,Rao, Z.; Crystal Structures of Membrane Transporter MmpL3, an Anti-TB Drug Target.; Cell, 176:636-648.e13, 2019; PubMed: 30682372; DOI: 10.1016/j.cell.2019.01.003

Experimental method

X-RAY DIFFRACTION (2.9 Å)