6O66

Structure of VX-phosphonylated hAChE in complex with oxime reactivator RS-170B

Summary for 6O66

Entry DOI	10.2210/pdb6o66/pdb
Related	6o5r 6o5s 6o5v
Descriptor	Acetylcholinesterase, 4-carbamoyl-1-(3-{2-[(E)-(hydroxyimino)methyl]-1H-imidazol-1-yl}propyl)pyridin-1-ium, GLYCEROL, ... (4 entities in total)
Functional Keywords	human acetylcholinesterase, vx-phosphonylated, vx-hache, oxime reactivator, imidazole-based oxime, rs-170b, hydrolase
Biological source	Homo sapiens (Human)
Total number of polymer chains	2
Total formula weight	122257.60
Authors	Gerlits, O.,Kovalevsky, A.,Radic, Z. (deposition date: 2019-03-05, release date: 2019-05-29, Last modification date: 2023-10-11)
Primary citation	Gerlits, O.,Kong, X.,Cheng, X.,Wymore, T.,Blumenthal, D.K.,Taylor, P.,Radic, Z.,Kovalevsky, A. Productive reorientation of a bound oxime reactivator revealed in room temperature X-ray structures of native and VX-inhibited human acetylcholinesterase. J.Biol.Chem., 294:10607-10618, 2019 Cited by PubMed: 31138650 DOI: 10.1074/jbc.RA119.008725 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.452 Å)

Structure validation