Loading
PDBj
MenuPDBj@FacebookPDBj@TwitterPDBj@YouTubewwPDB FoundationwwPDB
RCSB PDBPDBeBMRBAdv. SearchSearch help
Search by PDB author
1E90
DownloadVisualize
BU of 1e90 by Molmil
Structure determinants of phosphoinositide 3-kinase inhibition by wortmannin, LY294002, quercetin, myricetin and staurosporine
Descriptor: 3,5,7-TRIHYDROXY-2-(3,4,5-TRIHYDROXYPHENYL)-4H-CHROMEN-4-ONE, PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT
Authors:Walker, E.H, Pacold, M.E, Perisic, O, Stephens, L, Hawkins, P.T, Wymann, M.P, Williams, R.L.
Deposit date:2000-10-03
Release date:2000-11-17
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Structural Determinations of Phosphoinositide 3-Kinase Inhibition by Wortmannin, Ly294002, Quercetin, Myricetin and Staurosporine
Mol.Cell, 6, 2000
2CHW
DownloadVisualize
BU of 2chw by Molmil
A pharmacological map of the PI3-K family defines a role for p110 alpha in signaling: The structure of complex of phosphoinositide 3- kinase gamma with inhibitor PIK-39
Descriptor: 2-((9H-PURIN-6-YLTHIO)METHYL)-5-CHLORO-3-(2-METHOXYPHENYL)QUINAZOLIN-4(3H)-ONE, PHOSPHATIDYLINOSITOL-4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
Authors:Knight, Z.A, Gonzalez, B, Feldman, M.E, Zunder, E.R, Goldenberg, D.D, Williams, O, Loewith, R, Stokoe, D, Balla, A, Toth, B, Balla, T, Weiss, W.A, Williams, R.L, Shokat, K.M.
Deposit date:2006-03-16
Release date:2006-05-22
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:A Pharmacological Map of the Pi3-K Family Defines a Role for P110Alpha in Signaling
Cell(Cambridge,Mass.), 125, 2006
2CHZ
DownloadVisualize
BU of 2chz by Molmil
A pharmacological map of the PI3-K family defines a role for p110alpha in signaling: The structure of complex of phosphoinositide 3-kinase gamma with inhibitor PIK-93
Descriptor: N-(5-(4-CHLORO-3-(2-HYDROXY-ETHYLSULFAMOYL)- PHENYLTHIAZOLE-2-YL)-ACETAMIDE, PHOSPHATIDYLINOSITOL-4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
Authors:Knight, Z.A, Gonzalez, B, Feldman, M.E, Zunder, E.R, Goldenberg, D.D, Williams, O, Loewith, R, Stokoe, D, Balla, A, Toth, B, Balla, T, Weiss, W.A, Williams, R.L, Shokat, K.M.
Deposit date:2006-03-16
Release date:2006-05-22
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:A Pharmacological Map of the Pi3-K Family Defines a Role for P110Alpha in Signaling
Cell(Cambridge,Mass.), 125, 2006
2CHX
DownloadVisualize
BU of 2chx by Molmil
A pharmacological map of the PI3-K family defines a role for p110alpha in signaling: The structure of complex of phosphoinositide 3-kinase gamma with inhibitor PIK-90
Descriptor: N-(2,3-DIHYDRO-7,8-DIMETHOXYIMIDAZO[1,2-C] QUINAZOLIN-5-YL)NICOTINAMIDE, PHOSPHATIDYLINOSITOL-4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
Authors:Knight, Z.A, Gonzalez, B, Feldman, M.E, Zunder, E.R, Goldenberg, D.D, Williams, O, Loewith, R, Stokoe, D, Balla, A, Toth, B, Balla, T, Weiss, W.A, Williams, R.L, Shokat, K.M.
Deposit date:2006-03-16
Release date:2006-05-22
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:A Pharmacological Map of the Pi3-K Family Defines a Role for P110Alpha in Signaling
Cell(Cambridge,Mass.), 125, 2006
7OWG
DownloadVisualize
BU of 7owg by Molmil
human DEPTOR in a complex with mutant human mTORC1 A1459P
Descriptor: DEP domain-containing mTOR-interacting protein, Regulatory-associated protein of mTOR, Serine/threonine-protein kinase mTOR, ...
Authors:Heimhalt, M, Berndt, A, Wagstaff, J, Anandapadamanaban, M, Perisic, O, Maslen, S, McLaughlin, S, Yu, W.-H, Masson, G.R, Boland, A, Ni, X, Yamashita, K, Murshudov, G.N, Skehel, M, Freund, S.M, Williams, R.L.
Deposit date:2021-06-18
Release date:2021-09-08
Last modified:2024-07-17
Method:ELECTRON MICROSCOPY (4.7 Å)
Cite:Bipartite binding and partial inhibition links DEPTOR and mTOR in a mutually antagonistic embrace.
Elife, 10, 2021
5JHA
DownloadVisualize
BU of 5jha by Molmil
Structure of Phosphoinositide 3-kinase gamma (PI3K) bound to the potent inhibitor PIKin2
Descriptor: Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform, SULFATE ION, [1-{4-[6-amino-4-(trifluoromethyl)pyridin-3-yl]-6-(morpholin-4-yl)pyrimidin-2-yl}-3-(chloromethyl)azetidin-3-yl]methanol
Authors:Burke, J.E, Inglis, A.J, Williams, R.L.
Deposit date:2016-04-20
Release date:2017-03-15
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (2.51 Å)
Cite:Deconvolution of Buparlisib's mechanism of action defines specific PI3K and tubulin inhibitors for therapeutic intervention.
Nat Commun, 8, 2017
1UZX
DownloadVisualize
BU of 1uzx by Molmil
A complex of the Vps23 UEV with ubiquitin
Descriptor: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, SULFATE ION, UBIQUITIN, ...
Authors:Teo, H, Williams, R.L.
Deposit date:2004-03-18
Release date:2004-03-30
Last modified:2017-07-05
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Structural Insights Into Endosomal Sorting Complex Required for Transport (Escrt-I) Recognition of Ubiquitinated Proteins
J.Biol.Chem., 279, 2004
5KC2
DownloadVisualize
BU of 5kc2 by Molmil
Negative stain structure of Vps15/Vps34 complex
Descriptor: Phosphatidylinositol 3-kinase VPS34, Serine/threonine-protein kinase VPS15
Authors:Kirsten, M.L, Zhang, L, Ohashi, Y, Perisic, O, Williams, R.L, Sachse, C.
Deposit date:2016-06-04
Release date:2016-10-05
Last modified:2024-05-15
Method:ELECTRON MICROSCOPY (28 Å)
Cite:Characterization of Atg38 and NRBF2, a fifth subunit of the autophagic Vps34/PIK3C3 complex.
Autophagy, 12, 2016
1UPT
DownloadVisualize
BU of 1upt by Molmil
Structure of a complex of the golgin-245 GRIP domain with Arl1
Descriptor: ADP-RIBOSYLATION FACTOR-LIKE PROTEIN 1, GOLGI AUTOANTIGEN, GOLGIN SUBFAMILY A MEMBER 4, ...
Authors:Panic, B, Perisic, O, Veprintsev, D.B, Williams, R.L, Munro, S.
Deposit date:2003-10-12
Release date:2003-10-30
Last modified:2024-10-23
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Structural Basis for Arl1-Dependent Targeting of Homodimeric Grip Domains to the Golgi Apparatus
Mol.Cell, 12, 2003
6S6D
DownloadVisualize
BU of 6s6d by Molmil
Crystal structure of RagA-Q66L-GTP/RagC-S75N-GDP GTPase heterodimer complex
Descriptor: GUANOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ...
Authors:Anandapadamanaban, M, Masson, G.R, Perisic, O, Kaufman, J, Williams, R.L.
Deposit date:2019-07-02
Release date:2019-10-16
Last modified:2024-05-15
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Architecture of human Rag GTPase heterodimers and their complex with mTORC1.
Science, 366, 2019
1W2F
DownloadVisualize
BU of 1w2f by Molmil
Human Inositol (1,4,5)-trisphosphate 3-kinase substituted with selenomethionine
Descriptor: INOSITOL-TRISPHOSPHATE 3-KINASE A, SULFATE ION
Authors:Gonzalez, B, Schell, M.J, Irvine, R.F, Williams, R.L.
Deposit date:2004-07-01
Release date:2004-09-09
Last modified:2024-10-16
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structure of a Human Inositol 1,4,5-Trisphosphate 3-Kinase; Substrate Binding Reveals Why It is not a Phosphoinositide 3-Kinase
Mol.Cell, 15, 2004
6S6A
DownloadVisualize
BU of 6s6a by Molmil
Crystal structure of RagA-Q66L/RagC-T90N GTPase heterodimer complex
Descriptor: GUANOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ...
Authors:Anandapadamanaban, M, Masson, G.R, Perisic, O, Kaufman, J, Williams, R.L.
Deposit date:2019-07-02
Release date:2019-10-16
Last modified:2024-05-15
Method:X-RAY DIFFRACTION (2.63 Å)
Cite:Architecture of human Rag GTPase heterodimers and their complex with mTORC1.
Science, 366, 2019
6SB2
DownloadVisualize
BU of 6sb2 by Molmil
cryo-EM structure of mTORC1 bound to active RagA/C GTPases
Descriptor: GUANOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, Ras-related GTP-binding protein A, ...
Authors:Anandapadamanaban, M, Berndt, A, Masson, G.R, Perisic, O, Williams, R.L.
Deposit date:2019-07-18
Release date:2019-10-16
Last modified:2024-05-22
Method:ELECTRON MICROSCOPY (6.2 Å)
Cite:Architecture of human Rag GTPase heterodimers and their complex with mTORC1.
Science, 366, 2019
6SB0
DownloadVisualize
BU of 6sb0 by Molmil
cryo-EM structure of mTORC1 bound to PRAS40-fused active RagA/C GTPases
Descriptor: GUANOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, Proline-rich AKT1 substrate 1, ...
Authors:Anandapadamanaban, M, Berndt, A, Masson, G.R, Perisic, O, Williams, R.L.
Deposit date:2019-07-18
Release date:2019-10-16
Last modified:2024-05-22
Method:ELECTRON MICROSCOPY (5.5 Å)
Cite:Architecture of human Rag GTPase heterodimers and their complex with mTORC1.
Science, 366, 2019
1W2C
DownloadVisualize
BU of 1w2c by Molmil
Human Inositol (1,4,5) trisphosphate 3-kinase complexed with Mn2+/AMPPNP/Ins(1,4,5)P3
Descriptor: D-MYO-INOSITOL-1,4,5-TRIPHOSPHATE, INOSITOL-TRISPHOSPHATE 3-KINASE A, MANGANESE (II) ION, ...
Authors:Gonzalez, B, Schell, M.J, Irvine, R.F, Williams, R.L.
Deposit date:2004-07-01
Release date:2004-09-09
Last modified:2024-05-08
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Structure of a Human Inositol 1,4,5-Trisphosphate 3-Kinase; Substrate Binding Reveals Why It is not a Phosphoinositide 3-Kinase
Mol.Cell, 15, 2004
1W7P
DownloadVisualize
BU of 1w7p by Molmil
The crystal structure of endosomal complex ESCRT-II (VPS22/VPS25/VPS36)
Descriptor: VPS22, YPL002C, VPS25, ...
Authors:Teo, H, Perisic, O, Gonzalez, B, Williams, R.L.
Deposit date:2004-09-07
Release date:2004-09-29
Last modified:2024-05-08
Method:X-RAY DIFFRACTION (3.6 Å)
Cite:Escrt-II, an Endosome-Associated Complex Required for Protein Sorting: Crystal Structure and Interactions with Escrt-III and Membranes
Dev.Cell, 7, 2004
1W2D
DownloadVisualize
BU of 1w2d by Molmil
Human Inositol (1,4,5)-trisphosphate 3-kinase complexed with Mn2+/ADP/Ins(1,3,4,5)P4
Descriptor: ADENOSINE-5'-DIPHOSPHATE, INOSITOL-(1,3,4,5)-TETRAKISPHOSPHATE, INOSITOL-TRISPHOSPHATE 3-KINASE A, ...
Authors:Gonzalez, B, Schell, M.J, Irvine, R.F, Williams, R.L.
Deposit date:2004-07-01
Release date:2004-09-09
Last modified:2024-05-08
Method:X-RAY DIFFRACTION (1.94 Å)
Cite:Structure of a Human Inositol 1,4,5-Trisphosphate 3-Kinase; Substrate Binding Reveals Why It is not a Phosphoinositide 3-Kinase
Mol.Cell, 15, 2004
7PG5
DownloadVisualize
BU of 7pg5 by Molmil
Crystal Structure of PI3Kalpha
Descriptor: GLYCEROL, PHOSPHATE ION, Phosphatidylinositol 3-kinase regulatory subunit alpha, ...
Authors:Gong, G, Pinotsis, N, Williams, R.L, Vanhaesebroeck, B.
Deposit date:2021-08-13
Release date:2022-08-24
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2.20029068 Å)
Cite:A small-molecule PI3K alpha activator for cardioprotection and neuroregeneration.
Nature, 618, 2023
7PG6
DownloadVisualize
BU of 7pg6 by Molmil
Crystal Structure of PI3Kalpha in complex with the inhibitor NVP-BYL719
Descriptor: (2S)-N~1~-{4-methyl-5-[2-(1,1,1-trifluoro-2-methylpropan-2-yl)pyridin-4-yl]-1,3-thiazol-2-yl}pyrrolidine-1,2-dicarboxamide, Phosphatidylinositol 3-kinase regulatory subunit alpha, Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform, ...
Authors:Gong, G, Pinotsis, N, Williams, R.L, Vanhaesebroeck, B.
Deposit date:2021-08-13
Release date:2022-08-24
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2.49943733 Å)
Cite:A small-molecule PI3K alpha activator for cardioprotection and neuroregeneration.
Nature, 618, 2023
5FVM
DownloadVisualize
BU of 5fvm by Molmil
Cryo electron microscopy of a complex of Tor and Lst8
Descriptor: SERINE/THREONINE-PROTEIN KINASE TOR2, TARGET OF RAPAMYCIN COMPLEX SUBUNIT LST8
Authors:Baretic, D, Berndt, A, Ohashi, Y, Johnson, C.M, Williams, R.L.
Deposit date:2016-02-09
Release date:2016-04-20
Last modified:2024-05-08
Method:ELECTRON MICROSCOPY (6.7 Å)
Cite:Tor Forms a Dimer Through an N-Terminal Helical Solenoid with a Complex Topology
Nat.Commun., 7, 2016
8AJ8
DownloadVisualize
BU of 8aj8 by Molmil
Structure of p110 gamma bound to the p84 regulatory subunit
Descriptor: Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform, Phosphoinositide 3-kinase regulatory subunit 6
Authors:Burke, J.E, Williams, R.L, Zhang, X.
Deposit date:2022-07-27
Release date:2023-03-22
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (8.5 Å)
Cite:Molecular basis for differential activation of p101 and p84 complexes of PI3K gamma by Ras and GPCRs.
Cell Rep, 42, 2023
7BL1
DownloadVisualize
BU of 7bl1 by Molmil
human complex II-BATS bound to membrane-attached Rab5a-GTP
Descriptor: Beclin-1, GUANOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ...
Authors:Tremel, S, Morado, D.R, Kovtun, O, Williams, R.L, Briggs, J.A.G, Munro, S, Ohashi, Y, Bertram, J, Perisic, O.
Deposit date:2021-01-17
Release date:2021-03-03
Last modified:2024-05-01
Method:ELECTRON MICROSCOPY (9.8 Å)
Cite:Structural basis for VPS34 kinase activation by Rab1 and Rab5 on membranes.
Nat Commun, 12, 2021
1DJH
DownloadVisualize
BU of 1djh by Molmil
PHOSPHOINOSITIDE-SPECIFIC PHOSPHOLIPASE C-DELTA1 FROM RAT COMPLEXED WITH BARIUM
Descriptor: ACETATE ION, BARIUM ION, PHOSPHOINOSITIDE-SPECIFIC PHOSPHOLIPASE C, ...
Authors:Essen, L.-O, Perisic, O, Williams, R.L.
Deposit date:1996-09-25
Release date:1997-07-07
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:A ternary metal binding site in the C2 domain of phosphoinositide-specific phospholipase C-delta1.
Biochemistry, 36, 1997
1DJG
DownloadVisualize
BU of 1djg by Molmil
PHOSPHOINOSITIDE-SPECIFIC PHOSPHOLIPASE C-DELTA1 FROM RAT COMPLEXED WITH LANTHANUM
Descriptor: ACETATE ION, LANTHANUM (III) ION, PHOSPHOINOSITIDE-SPECIFIC PHOSPHOLIPASE C, ...
Authors:Essen, L.-O, Perisic, O, Williams, R.L.
Deposit date:1996-09-25
Release date:1997-07-07
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:A ternary metal binding site in the C2 domain of phosphoinositide-specific phospholipase C-delta1.
Biochemistry, 36, 1997
1DJI
DownloadVisualize
BU of 1dji by Molmil
PHOSPHOINOSITIDE-SPECIFIC PHOSPHOLIPASE C-DELTA1 FROM RAT COMPLEXED WITH CALCIUM
Descriptor: ACETATE ION, CALCIUM ION, PHOSPHOINOSITIDE-SPECIFIC PHOSPHOLIPASE C, ...
Authors:Essen, L.-O, Perisic, O, Williams, R.L.
Deposit date:1996-09-25
Release date:1997-07-07
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:A ternary metal binding site in the C2 domain of phosphoinositide-specific phospholipase C-delta1.
Biochemistry, 36, 1997

227111

數據於2024-11-06公開中

PDB statisticsPDBj update infoContact PDBjnumon