1W2C

Human Inositol (1,4,5) trisphosphate 3-kinase complexed with Mn2+/AMPPNP/Ins(1,4,5)P3

Summary for 1W2C

Entry DOI	10.2210/pdb1w2c/pdb
Related	1W2D 1W2F
Descriptor	INOSITOL-TRISPHOSPHATE 3-KINASE A, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, D-MYO-INOSITOL-1,4,5-TRIPHOSPHATE, ... (6 entities in total)
Functional Keywords	inositol phosphate kinase, amppnp, ip3, transferase
Biological source	HOMO SAPIENS (HUMAN)
Total number of polymer chains	2
Total formula weight	63101.95
Authors	Gonzalez, B.,Schell, M.J.,Irvine, R.F.,Williams, R.L. (deposition date: 2004-07-01, release date: 2004-09-09, Last modification date: 2018-01-24)
Primary citation	Gonzalez, B.,Schell, M.J.,Letcher, A.J.,Veprintsev, D.B.,Irvine, R.F.,Williams, R.L. Structure of a Human Inositol 1,4,5-Trisphosphate 3-Kinase; Substrate Binding Reveals Why It is not a Phosphoinositide 3-Kinase Mol.Cell, 15:689-, 2004 Cited by PubMed: 15350214 DOI: 10.1016/J.MOLCEL.2004.08.004 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.95 Å)

Structure validation