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Early transcription elongation state of influenza B polymerase backtracked due to double incoproation of nucleotide analogue T1106
Descriptor:	3' vRNA, 5' vRNA, MAGNESIUM ION, ...
Authors:	Cusack, S, Kouba, T.
Deposit date:	2022-02-02
Release date:	2022-12-28
Last modified:	2024-07-17
Method:	ELECTRON MICROSCOPY (2.58 Å)
Cite:	Direct observation of backtracking by influenza A and B polymerases upon consecutive incorporation of the nucleoside analog T1106. Cell Rep, 42, 2023

7R0E

Early transcription elongation state of influenza A/H7N9 polymerase backtracked due to double incoproation of nucleotide analogue T1106 and with singly incoporated T1106 at the +1 position
Descriptor:	3' vRNA, 5' vRNA, MAGNESIUM ION, ...
Authors:	Cusack, S, Kouba, T.
Deposit date:	2022-02-01
Release date:	2022-12-28
Last modified:	2024-07-17
Method:	ELECTRON MICROSCOPY (2.51 Å)
Cite:	Direct observation of backtracking by influenza A and B polymerases upon consecutive incorporation of the nucleoside analog T1106. Cell Rep, 42, 2023

5MSG

Influenza B polymerase bound to vRNA promoter and capped RNA primer
Descriptor:	PHOSPHATE ION, Polymerase acidic protein, Polymerase basic protein 2, ...
Authors:	Cusack, S, Guilligay, D.
Deposit date:	2017-01-04
Release date:	2017-02-08
Last modified:	2024-03-06
Method:	X-RAY DIFFRACTION (3.8 Å)
Cite:	An in vitro fluorescence based study of initiation of RNA synthesis by influenza B polymerase. Nucleic Acids Res., 45, 2017

7ZPM

Influenza A/H7N9 polymerase apo-protein dimer complex
Descriptor:	Polymerase acidic protein, Polymerase basic protein 2, RNA-directed RNA polymerase catalytic subunit
Authors:	Cusack, S, Kouba, T.
Deposit date:	2022-04-27
Release date:	2022-12-28
Last modified:	2024-07-24
Method:	ELECTRON MICROSCOPY (2.81 Å)
Cite:	Direct observation of backtracking by influenza A and B polymerases upon consecutive incorporation of the nucleoside analog T1106. Cell Rep, 42, 2023

7ZPL

Symmetric dimer of influenza A/H7N9 polymerase bound to 5' vRNA hook
Descriptor:	5' vRNA, MAGNESIUM ION, Polymerase acidic protein, ...
Authors:	Cusack, S, Kouba, T.
Deposit date:	2022-04-27
Release date:	2022-12-28
Last modified:	2024-07-24
Method:	ELECTRON MICROSCOPY (3.12 Å)
Cite:	Direct observation of backtracking by influenza A and B polymerases upon consecutive incorporation of the nucleoside analog T1106. Cell Rep, 42, 2023

8BE0

Early transcription elongation state of influenza B/Mem polymerase backtracked due to double incoproation of nucleotide analogue T1106 and with singly incoporated T1106 at the C +1 position
Descriptor:	3' vRNA, 5' vRNA, MAGNESIUM ION, ...
Authors:	Cusack, S, Kouba, T.
Deposit date:	2022-10-20
Release date:	2022-12-28
Last modified:	2024-07-24
Method:	ELECTRON MICROSCOPY (2.34 Å)
Cite:	Direct observation of backtracking by influenza A and B polymerases upon consecutive incorporation of the nucleoside analog T1106. Cell Rep, 42, 2023

8BDR

Early transcription elongation state of influenza B/Mem polymerase backtracked due to double incoproation of nucleotide analogue T1106 and with singly incoporated T1106 at the U +1 position
Descriptor:	3' vRNA, 5' vRNA, MAGNESIUM ION, ...
Authors:	Cusack, S, Kouba, T.
Deposit date:	2022-10-19
Release date:	2022-12-28
Last modified:	2024-07-24
Method:	ELECTRON MICROSCOPY (2.7 Å)
Cite:	Direct observation of backtracking by influenza A and B polymerases upon consecutive incorporation of the nucleoside analog T1106. Cell Rep, 42, 2023

8BEK

Early transcription elongation state of influenza A/H7N9 backtracked polymerase with singly incoporated T1106 at the U +1 position
Descriptor:	3' vRNA, 5' vRNA, MAGNESIUM ION, ...
Authors:	Cusack, S, Kouba, T.
Deposit date:	2022-10-21
Release date:	2022-12-28
Last modified:	2024-07-24
Method:	ELECTRON MICROSCOPY (2.86 Å)
Cite:	Direct observation of backtracking by influenza A and B polymerases upon consecutive incorporation of the nucleoside analog T1106. Cell Rep, 42, 2023

8BF5

Early transcription elongation state of influenza A/H7N9 polymerase stalled with incoming GTP analogue
Descriptor:	3' vRNA, 5' vRNA, MAGNESIUM ION, ...
Authors:	Cusack, S, Kouba, T.
Deposit date:	2022-10-24
Release date:	2022-12-28
Last modified:	2024-07-24
Method:	ELECTRON MICROSCOPY (2.96 Å)
Cite:	Direct observation of backtracking by influenza A and B polymerases upon consecutive incorporation of the nucleoside analog T1106. Cell Rep, 42, 2023

1ADY

HISTIDYL-TRNA SYNTHETASE IN COMPLEX WITH HISTIDYL-ADENYLATE
Descriptor:	HISTIDYL-ADENOSINE MONOPHOSPHATE, HISTIDYL-TRNA SYNTHETASE, SULFATE ION
Authors:	Cusack, S, Aberg, A.
Deposit date:	1997-02-19
Release date:	1997-08-20
Last modified:	2024-04-03
Method:	X-RAY DIFFRACTION (2.8 Å)
Cite:	Crystal structure analysis of the activation of histidine by Thermus thermophilus histidyl-tRNA synthetase. Biochemistry, 36, 1997

1ADJ

HISTIDYL-TRNA SYNTHETASE IN COMPLEX WITH HISTIDINE
Descriptor:	HISTIDINE, HISTIDYL-TRNA SYNTHETASE, SULFATE ION
Authors:	Cusack, S, Aberg, A.
Deposit date:	1997-02-18
Release date:	1997-08-20
Last modified:	2024-02-07
Method:	X-RAY DIFFRACTION (2.7 Å)
Cite:	Crystal structure analysis of the activation of histidine by Thermus thermophilus histidyl-tRNA synthetase. Biochemistry, 36, 1997

1H4V

HISTIDYL-TRNA SYNTHETASE from Thermus Thermophilus (ligand free)
Descriptor:	HISTIDYL-TRNA SYNTHETASE, SULFATE ION
Authors:	Cusack, S, Yaremchuk, A, Tukalo, M.
Deposit date:	2001-05-14
Release date:	2001-06-18
Last modified:	2023-12-13
Method:	X-RAY DIFFRACTION (2.4 Å)
Cite:	A Succession of Substrate Induced Conformational Changes Ensures the Amino Acid Specificity of Thermus Thermophilus Prolyl-tRNA Synthetase: Comparison with Histidyl-tRNA Synthetase J.Mol.Biol., 309, 2001

5JCH

Crystal structure of chicken MDA5 with 5'p 10-mer dsRNA and ADP-Mg2+ at 2.95 A resolution (untwinned).
Descriptor:	ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, Melanoma differentiation associated protein-5, ...
Authors:	Cusack, S, Uchikawa, E.
Deposit date:	2016-04-15
Release date:	2016-06-01
Last modified:	2024-01-10
Method:	X-RAY DIFFRACTION (2.95 Å)
Cite:	Structural Analysis of dsRNA Binding to Anti-viral Pattern Recognition Receptors LGP2 and MDA5. Mol.Cell, 62, 2016

5JBJ

Crystal structure of chicken LGP2 with 5'p 12-mer dsRNA at 3.6 A resolution
Descriptor:	LGP2, RNA (5'-R(PGPGPUPAPGPCPGPCPUPAPCPC)-3'), ZINC ION
Authors:	Cusack, S, Uchikawa, E, Lethier, M.
Deposit date:	2016-04-13
Release date:	2016-06-01
Last modified:	2024-01-10
Method:	X-RAY DIFFRACTION (3.58 Å)
Cite:	Structural Analysis of dsRNA Binding to Anti-viral Pattern Recognition Receptors LGP2 and MDA5. Mol.Cell, 62, 2016

5JC3

Crystal structure of chicken MDA5 with 5'p 10-mer dsRNA and ADP-Mg2+ at 2.6 A resolution (monoclinic form, twinned).
Descriptor:	ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, Melanoma differentiation associated protein-5, ...
Authors:	Cusack, S, Uchikawa, E.
Deposit date:	2016-04-14
Release date:	2016-06-01
Last modified:	2024-01-10
Method:	X-RAY DIFFRACTION (2.6 Å)
Cite:	Structural Analysis of dsRNA Binding to Anti-viral Pattern Recognition Receptors LGP2 and MDA5. Mol.Cell, 62, 2016

5JCF

Crystal structure of chicken MDA5 with 5'p 10-mer dsRNA and ADP-Mg2+ at 2.6 A resolution (orthorhombic form).
Descriptor:	ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, Melanoma differentiation associated protein-5, ...
Authors:	Cusack, S, Uchikawa, E.
Deposit date:	2016-04-15
Release date:	2016-06-01
Last modified:	2024-01-10
Method:	X-RAY DIFFRACTION (2.6 Å)
Cite:	Structural Analysis of dsRNA Binding to Anti-viral Pattern Recognition Receptors LGP2 and MDA5. Mol.Cell, 62, 2016

5JC7

Crystal structure of chicken MDA5 with 5'p 24-mer dsRNA and ADP-Mg2+ at 2.75 A resolution.
Descriptor:	ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, Melanoma differentiation associated protein-5, ...
Authors:	Cusack, S, Uchikawa, E.
Deposit date:	2016-04-14
Release date:	2016-06-01
Last modified:	2024-01-10
Method:	X-RAY DIFFRACTION (2.75 Å)
Cite:	Structural Analysis of dsRNA Binding to Anti-viral Pattern Recognition Receptors LGP2 and MDA5. Mol.Cell, 62, 2016

5JAJ

Structure of chicken LGP2 witha 5'p 10-mer dsRNA and ADP-AlF4-Mg.
Descriptor:	1,2-ETHANEDIOL, ADENOSINE-5'-DIPHOSPHATE, LGP2, ...
Authors:	Cusack, S, Uchikawa, E.
Deposit date:	2016-04-12
Release date:	2016-06-01
Last modified:	2024-01-10
Method:	X-RAY DIFFRACTION (1.5 Å)
Cite:	Structural Analysis of dsRNA Binding to Anti-viral Pattern Recognition Receptors LGP2 and MDA5. Mol.Cell, 62, 2016

5JB2

Crystal structure of chicken LGP2 with 5'ppp 10-mer dsRNA and ADP-AlF4-Mg2+ at 2.2 A resolution.
Descriptor:	ADENOSINE-5'-DIPHOSPHATE, LGP2, MAGNESIUM ION, ...
Authors:	Cusack, S, Uchikawa, E.
Deposit date:	2016-04-13
Release date:	2016-06-01
Last modified:	2024-01-10
Method:	X-RAY DIFFRACTION (2.2 Å)
Cite:	Structural Analysis of dsRNA Binding to Anti-viral Pattern Recognition Receptors LGP2 and MDA5. Mol.Cell, 62, 2016

5JBG

Crystal structure of chicken LGP2 with 5'ppp 26-mer hairpin RNA with 3' GG overhang and ADP-AlF4-Mg2+ at 2.0 A resolution.
Descriptor:	ADENOSINE-5'-DIPHOSPHATE, LGP2, MAGNESIUM ION, ...
Authors:	Cusack, S, Uchikawa, E.
Deposit date:	2016-04-13
Release date:	2016-06-01
Last modified:	2024-01-10
Method:	X-RAY DIFFRACTION (2 Å)
Cite:	Structural Analysis of dsRNA Binding to Anti-viral Pattern Recognition Receptors LGP2 and MDA5. Mol.Cell, 62, 2016

6EUX

Structure of the midlink and cap-binding domains of influenza B polymerase PB2 subunit with a bound azaindazole cap-binding inhibitor
Descriptor:	(2~{S},3~{S})-3-[[5-fluoranyl-2-(5-fluoranyl-1~{H}-pyrazolo[3,4-b]pyridin-3-yl)pyrimidin-4-yl]amino]bicyclo[2.2.2]octane-2-carboxylic acid, Polymerase basic protein 2
Authors:	Cusack, S, Gaudon, S.
Deposit date:	2017-10-31
Release date:	2017-12-13
Last modified:	2024-01-17
Method:	X-RAY DIFFRACTION (2.05 Å)
Cite:	Capped RNA primer binding to influenza polymerase and implications for the mechanism of cap-binding inhibitors. Nucleic Acids Res., 46, 2018

6EUV

Structure of the midlink and cap-binding domains of influenza A polymerase PB2 subunit with a bound azaindole cap-binding inhibitor (VX-787)
Descriptor:	(2S,3S)-3-[[5-fluoranyl-2-(5-fluoranyl-1H-pyrrolo[2,3-b]pyridin-3-yl)pyrimidin-4-yl]amino]bicyclo[2.2.2]octane-2-carboxylic acid, NICKEL (II) ION, Polymerase basic protein 2
Authors:	Cusack, S, Lethier, M.
Deposit date:	2017-10-31
Release date:	2017-12-13
Last modified:	2024-01-17
Method:	X-RAY DIFFRACTION (2.7 Å)
Cite:	Capped RNA primer binding to influenza polymerase and implications for the mechanism of cap-binding inhibitors. Nucleic Acids Res., 46, 2018

6EUY

Structure of the midlink and cap-binding domains of influenza A polymerase PB2 subunit with a bound azaindazole cap-binding inhibitor
Descriptor:	(2~{S},3~{S})-3-[[5-fluoranyl-2-(5-fluoranyl-1~{H}-pyrazolo[3,4-b]pyridin-3-yl)pyrimidin-4-yl]amino]bicyclo[2.2.2]octane-2-carboxylic acid, Polymerase basic protein 2, SULFATE ION
Authors:	Cusack, S, Gaudon, S.
Deposit date:	2017-10-31
Release date:	2017-12-13
Last modified:	2024-01-17
Method:	X-RAY DIFFRACTION (3 Å)
Cite:	Capped RNA primer binding to influenza polymerase and implications for the mechanism of cap-binding inhibitors. Nucleic Acids Res., 46, 2018

6EUW

Crystal structure of the cap-binding domain of the PB2 subunit of influenza A/H5N1 polymerase bound to an azaindazole inhibitor
Descriptor:	(2~{S},3~{S})-3-[[5-fluoranyl-2-(5-fluoranyl-1~{H}-pyrazolo[3,4-b]pyridin-3-yl)pyrimidin-4-yl]amino]bicyclo[2.2.2]octane-2-carboxylic acid, GLYCEROL, Polymerase basic protein 2
Authors:	Cusack, S, Gaudon, S.
Deposit date:	2017-10-31
Release date:	2017-12-13
Last modified:	2024-01-17
Method:	X-RAY DIFFRACTION (1 Å)
Cite:	Capped RNA primer binding to influenza polymerase and implications for the mechanism of cap-binding inhibitors. Nucleic Acids Res., 46, 2018

5OOB

COMPLEX OF HUMAN NUCLEAR CAP-BINDING COMPLEX WITH M7GTP AND NELF-E C-TERMINAL PEPTIDE
Descriptor:	7N-METHYL-8-HYDROGUANOSINE-5'-TRIPHOSPHATE, Negative elongation factor E, Nuclear cap-binding protein subunit 1, ...
Authors:	Cusack, S, Schulze, W.M.
Deposit date:	2017-08-07
Release date:	2017-11-15
Last modified:	2024-01-17
Method:	X-RAY DIFFRACTION (2.79 Å)
Cite:	Structural basis for mutually exclusive co-transcriptional nuclear cap-binding complexes with either NELF-E or ARS2. Nat Commun, 8, 2017

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