5JC7

Crystal structure of chicken MDA5 with 5'p 24-mer dsRNA and ADP-Mg2+ at 2.75 A resolution.

Summary for 5JC7

• Entry DOI: 10.2210/pdb5jc7/pdb
• Descriptor: Melanoma differentiation associated protein-5, RNA (5'-R(P*GP*GP*AP*CP*GP*UP*CP*AP*UP*GP*CP*GP*CP*AP*UP*GP*AP*CP*GP*UP*CP*CP*CP*C)-3'), RNA (5'-R(P*GP*GP*GP*AP*CP*GP*UP*CP*AP*UP*GP*CP*GP*CP*AP*UP*GP*AP*CP*GP*UP*CP*CP*C)-3'), ... (6 entities in total)
• Functional Keywords: innate immune pattern recognition receptor, rig-i like helicase, dsrna dependent atpase, zinc-containing ctd domain, immune system
• Biological source: Gallus gallus (Chicken); More
• Total number of polymer chains: 4
• Total formula weight: 180072.29

Authors

Cusack, S.,Uchikawa, E. (deposition date: 2016-04-14, release date: 2016-06-01, Last modification date: 2024-01-10)

• Primary citation: Uchikawa, E.,Lethier, M.,Malet, H.,Brunel, J.,Gerlier, D.,Cusack, S.; Structural Analysis of dsRNA Binding to Anti-viral Pattern Recognition Receptors LGP2 and MDA5.; Mol.Cell, 62:586-602, 2016; PubMed: 27203181; DOI: 10.1016/j.molcel.2016.04.021

Experimental method

X-RAY DIFFRACTION (2.75 Å)