8PU6
 
 | | Structure of immature HTLV-1 CA-NTD from in vitro assembled MA126-CANC tubes: pooled class | | Descriptor: | Gag protein (Fragment) | | Authors: | Obr, M, Percipalle, M, Chernikova, D, Yang, H, Thader, A, Pinke, G, Porley, D, Mansky, L.M, Dick, R.A, Schur, F.K.M. | | Deposit date: | 2023-07-17 | | Release date: | 2023-08-23 | | Method: | ELECTRON MICROSCOPY (3.4 Å) | | Cite: | Unconventional stabilization of the human T-cell leukemia virus type 1 immature Gag lattice.
Biorxiv, 2023
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8PUF
 | | Structure of immature HTLV-1 CA-NTD from in vitro assembled MA126-CANC tubes: axis angle 20 degrees | | Descriptor: | Gag protein (Fragment) | | Authors: | Obr, M, Percipalle, M, Chernikova, D, Yang, H, Thader, A, Pinke, G, Porley, D, Mansky, L.M, Dick, R.A, Schur, F.K.M. | | Deposit date: | 2023-07-17 | | Release date: | 2023-08-23 | | Method: | ELECTRON MICROSCOPY (6.1 Å) | | Cite: | Unconventional stabilization of the human T-cell leukemia virus type 1 immature Gag lattice.
Biorxiv, 2023
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7E3K
 | | Ultrapotent SARS-CoV-2 neutralizing antibodies with protective efficacy against newly emerged mutational variants | | Descriptor: | 13G9 heavy chain, 13G9 light chain, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | Authors: | Guo, H, Li, T, Liu, F, Gao, Y, Ji, X, Yang, H. | | Deposit date: | 2021-02-09 | | Release date: | 2021-09-15 | | Last modified: | 2022-03-02 | | Method: | ELECTRON MICROSCOPY (3.9 Å) | | Cite: | Potent SARS-CoV-2 neutralizing antibodies with protective efficacy against newly emerged mutational variants.
Nat Commun, 12, 2021
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7E3L
 | | Ultrapotent SARS-CoV-2 neutralizing antibodies with protective efficacy against newly emerged mutational variants | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 58G6 heavy chain, 58G6 light chain, ... | | Authors: | Guo, H, Li, T, Liu, F, Gao, Y, Ji, X, Yang, H. | | Deposit date: | 2021-02-09 | | Release date: | 2021-09-15 | | Last modified: | 2022-03-02 | | Method: | ELECTRON MICROSCOPY (3.6 Å) | | Cite: | Potent SARS-CoV-2 neutralizing antibodies with protective efficacy against newly emerged mutational variants.
Nat Commun, 12, 2021
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7DW0
 | | SARS-CoV-2 Mpro mutant (H41A) in complex with nsp14|15 peptidyl substrate | | Descriptor: | 3C-like proteinase, nsp14/15 peptidyl substrate | | Authors: | Liu, X, Zhao, Y, Yang, H, Rao, Z. | | Deposit date: | 2021-01-15 | | Release date: | 2022-01-19 | | Last modified: | 2023-11-29 | | Method: | X-RAY DIFFRACTION (1.81 Å) | | Cite: | Structural basis for replicase polyprotein cleavage and substrate specificity of main protease from SARS-CoV-2.
Proc.Natl.Acad.Sci.USA, 119, 2022
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7DW6
 | | SARS-CoV-2 Mpro mutant (H41A) in complex with nsp15|16 peptidyl substrate | | Descriptor: | 3C-like proteinase, nsp15/16 peptidyl substrate | | Authors: | Liu, X, Zhao, Y, Yang, H, Rao, Z. | | Deposit date: | 2021-01-15 | | Release date: | 2022-01-19 | | Last modified: | 2023-11-29 | | Method: | X-RAY DIFFRACTION (1.7 Å) | | Cite: | Structural basis for replicase polyprotein cleavage and substrate specificity of main protease from SARS-CoV-2.
Proc.Natl.Acad.Sci.USA, 119, 2022
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7DVP
 | | SARS-CoV-2 Mpro mutant (H41A) in complex with nsp4|5 peptidyl substrate | | Descriptor: | 3C-like proteinase, nsp4/5 peptidyl substrate | | Authors: | Liu, X, Zhao, Y, Yang, H, Rao, Z. | | Deposit date: | 2021-01-14 | | Release date: | 2022-01-19 | | Last modified: | 2023-11-29 | | Method: | X-RAY DIFFRACTION (1.69 Å) | | Cite: | Structural basis for replicase polyprotein cleavage and substrate specificity of main protease from SARS-CoV-2.
Proc.Natl.Acad.Sci.USA, 119, 2022
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7DVW
 | | SARS-CoV-2 Mpro mutant (H41A) in complex with nsp5|6 peptidyl substrate | | Descriptor: | 3C-like proteinase, DIMETHYL SULFOXIDE, nsp5/6 peptidyl substrate | | Authors: | Liu, X, Zhao, Y, Yang, H, Rao, Z. | | Deposit date: | 2021-01-15 | | Release date: | 2022-01-19 | | Last modified: | 2023-11-29 | | Method: | X-RAY DIFFRACTION (1.49 Å) | | Cite: | Structural basis for replicase polyprotein cleavage and substrate specificity of main protease from SARS-CoV-2.
Proc.Natl.Acad.Sci.USA, 119, 2022
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7DVY
 | | SARS-CoV-2 Mpro mutant (H41A) in complex with nsp9|10 peptidyl substrate | | Descriptor: | 3C-like proteinase, nsp9/10 peptidyl substrate | | Authors: | Liu, X, Zhao, Y, Yang, H, Rao, Z. | | Deposit date: | 2021-01-15 | | Release date: | 2022-01-19 | | Last modified: | 2023-11-29 | | Method: | X-RAY DIFFRACTION (1.8 Å) | | Cite: | Structural basis for replicase polyprotein cleavage and substrate specificity of main protease from SARS-CoV-2.
Proc.Natl.Acad.Sci.USA, 119, 2022
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7DVX
 | | SARS-CoV-2 Mpro mutant (H41A) in complex with nsp6|7 peptidyl substrate | | Descriptor: | 3C-like proteinase, nsp6/7 peptidyl substrate | | Authors: | Liu, X, Zhao, Y, Yang, H, Rao, Z. | | Deposit date: | 2021-01-15 | | Release date: | 2022-01-19 | | Last modified: | 2023-11-29 | | Method: | X-RAY DIFFRACTION (1.8 Å) | | Cite: | Structural basis for replicase polyprotein cleavage and substrate specificity of main protease from SARS-CoV-2.
Proc.Natl.Acad.Sci.USA, 119, 2022
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7E5X
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7VAH
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7WIV
 | | Cryo-EM structure of Mycobacterium tuberculosis irtAB in complex with an AMP-PNP | | Descriptor: | Mycobactin import ATP-binding/permease protein IrtA, Mycobactin import ATP-binding/permease protein IrtB, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER | | Authors: | Zhang, B, Sun, S, Yang, H, Rao, Z. | | Deposit date: | 2022-01-05 | | Release date: | 2023-01-25 | | Last modified: | 2024-04-10 | | Method: | ELECTRON MICROSCOPY (2.88 Å) | | Cite: | Cryo-EM structures for the Mycobacterium tuberculosis iron-loaded siderophore transporter IrtAB.
Protein Cell, 14, 2023
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7WIX
 | | Cryo-EM structure of Mycobacterium tuberculosis irtAB in complex with ADP | | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, Mycobactin import ATP-binding/permease protein IrtA, ... | | Authors: | Zhang, B, Sun, S, Yang, H, Rao, Z. | | Deposit date: | 2022-01-05 | | Release date: | 2023-01-25 | | Last modified: | 2024-04-10 | | Method: | ELECTRON MICROSCOPY (3.53 Å) | | Cite: | Cryo-EM structures for the Mycobacterium tuberculosis iron-loaded siderophore transporter IrtAB.
Protein Cell, 14, 2023
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7WIU
 | | Cryo-EM structure of Mycobacterium tuberculosis irtAB in inward-facing state | | Descriptor: | Mycobactin import ATP-binding/permease protein IrtA, Mycobactin import ATP-binding/permease protein IrtB | | Authors: | Zhang, B, Sun, S, Yang, H, Rao, Z. | | Deposit date: | 2022-01-05 | | Release date: | 2023-01-25 | | Last modified: | 2024-04-10 | | Method: | ELECTRON MICROSCOPY (3.48 Å) | | Cite: | Cryo-EM structures for the Mycobacterium tuberculosis iron-loaded siderophore transporter IrtAB.
Protein Cell, 14, 2023
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7WIW
 | | Cryo-EM structure of Mycobacterium tuberculosis irtAB complexed with ATP in an occluded conformation | | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, Mycobactin import ATP-binding/permease protein IrtA, ... | | Authors: | Zhang, B, Sun, S, Yang, H, Rao, Z. | | Deposit date: | 2022-01-05 | | Release date: | 2023-01-25 | | Last modified: | 2024-04-10 | | Method: | ELECTRON MICROSCOPY (3.12 Å) | | Cite: | Cryo-EM structures for the Mycobacterium tuberculosis iron-loaded siderophore transporter IrtAB.
Protein Cell, 14, 2023
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6M49
 | | cryo-EM structure of Scap/Insig complex in the present of 25-hydroxyl cholesterol. | | Descriptor: | 25-HYDROXYCHOLESTEROL, Insulin-induced gene 2 protein, Sterol regulatory element-binding protein cleavage-activating protein,Sterol regulatory element-binding protein cleavage-activating protein | | Authors: | Yan, R, Cao, P, Song, W, Qian, H, Du, X, Coates, H.W, Zhao, X, Li, Y, Gao, S, Gong, X, Liu, X, Sui, J, Lei, J, Yang, H, Brown, A.J, Zhou, Q, Yan, C, Yan, N. | | Deposit date: | 2020-03-06 | | Release date: | 2021-01-20 | | Last modified: | 2024-03-27 | | Method: | ELECTRON MICROSCOPY (3.7 Å) | | Cite: | A structure of human Scap bound to Insig-2 suggests how their interaction is regulated by sterols.
Science, 371, 2021
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5XKA
 | | Crystal structure of M.tuberculosis PknI kinase domain | | Descriptor: | Serine/threonine-protein kinase PknI | | Authors: | Yan, Q, Jiang, D, Qian, L, Zhang, Q, Zhang, W, Zhou, W, Mi, K, Guddat, L, Yang, H, Rao, Z. | | Deposit date: | 2017-05-06 | | Release date: | 2018-05-16 | | Method: | X-RAY DIFFRACTION (1.599 Å) | | Cite: | Structural Insight into the Activation of PknI Kinase from M. tuberculosis via Dimerization of the Extracellular Sensor Domain.
Structure, 25, 2017
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5ZHY
 | | Structural characterization of the HCoV-229E fusion core | | Descriptor: | Spike glycoprotein | | Authors: | Zhang, W, Zheng, Q, Yan, M, Chen, X, Yang, H, Zhou, W, Rao, Z. | | Deposit date: | 2018-03-13 | | Release date: | 2018-06-06 | | Last modified: | 2023-11-22 | | Method: | X-RAY DIFFRACTION (2.441 Å) | | Cite: | Structural characterization of the HCoV-229E fusion core.
Biochem. Biophys. Res. Commun., 497, 2018
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6LND
 | | Crystal structure of transposition protein TniQ | | Descriptor: | ZINC ION, transposition protein TniQ | | Authors: | Wang, B, Xu, W, Yang, H. | | Deposit date: | 2019-12-28 | | Release date: | 2020-02-19 | | Method: | X-RAY DIFFRACTION (2.001 Å) | | Cite: | Structural basis of a Tn7-like transposase recruitment and DNA loading to CRISPR-Cas surveillance complex.
Cell Res., 30, 2020
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6LNB
 | | CryoEM structure of Cascade-TniQ-dsDNA complex | | Descriptor: | CRISPR RNA (60-MER), CRISPR-associated protein Cas6, CRISPR-associated protein Cas7, ... | | Authors: | Wang, B, Xu, W, Yang, H. | | Deposit date: | 2019-12-28 | | Release date: | 2020-02-19 | | Last modified: | 2024-03-27 | | Method: | ELECTRON MICROSCOPY (3.18 Å) | | Cite: | Structural basis of a Tn7-like transposase recruitment and DNA loading to CRISPR-Cas surveillance complex.
Cell Res., 30, 2020
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6LNC
 | | CryoEM structure of Cascade-TniQ complex | | Descriptor: | CRISPR RNA (60-MER), CRISPR-associated protein Cas6, CRISPR-associated protein Cas7, ... | | Authors: | Wang, B, Xu, W, Yang, H. | | Deposit date: | 2019-12-28 | | Release date: | 2020-02-19 | | Last modified: | 2024-03-27 | | Method: | ELECTRON MICROSCOPY (3.21 Å) | | Cite: | Structural basis of a Tn7-like transposase recruitment and DNA loading to CRISPR-Cas surveillance complex.
Cell Res., 30, 2020
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6NR3
 | | Cryo-EM structure of the TRPM8 ion channel in complex with high occupancy icilin, PI(4,5)P2, and calcium | | Descriptor: | (2S)-1-{[(R)-hydroxy{[(1R,2R,3S,4R,5R,6S)-2,3,6-trihydroxy-4,5-bis(phosphonooxy)cyclohexyl]oxy}phosphoryl]oxy}-3-(octadecanoyloxy)propan-2-yl icosa-5,8,11,14-tetraenoate, CALCIUM ION, Icilin, ... | | Authors: | Yin, Y, Le, S.C, Hsu, A.L, Borgnia, M.J, Yang, H, Lee, S.-Y. | | Deposit date: | 2019-01-22 | | Release date: | 2019-02-20 | | Last modified: | 2019-12-18 | | Method: | ELECTRON MICROSCOPY (3.4 Å) | | Cite: | Structural basis of cooling agent and lipid sensing by the cold-activated TRPM8 channel.
Science, 363, 2019
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7DMQ
 | | Cryo-EM structure of LshCas13a-crRNA-anti-tag RNA complex | | Descriptor: | Anti-tag target RNA, CRISPR RNA, CRISPR/Cas system Cas13a | | Authors: | Wang, B, Zhang, T, Ding, J, Patel, D.J, Yang, H. | | Deposit date: | 2020-12-05 | | Release date: | 2021-02-10 | | Last modified: | 2024-03-27 | | Method: | ELECTRON MICROSCOPY (3.06 Å) | | Cite: | Structural basis for self-cleavage prevention by tag:anti-tag pairing complementarity in type VI Cas13 CRISPR systems.
Mol.Cell, 81, 2021
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7VMU
 | | Crystal Structure of SARS-CoV Spike Receptor-Binding Domain Complexed with Neutralizing Antibody | | Descriptor: | Spike protein S1, scFv E4 | | Authors: | Guo, Y, Wang, W, Jiao, P, Yang, H, Rao, Z, Cheng, G. | | Deposit date: | 2021-10-09 | | Release date: | 2021-11-03 | | Last modified: | 2023-11-29 | | Method: | X-RAY DIFFRACTION (2.89 Å) | | Cite: | Antibody engineering improves neutralization activity against K417 spike mutant SARS-CoV-2 variants.
Cell Biosci, 12, 2022
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