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Engineered lipocalin C3A5 in complex with a transition state analog
Descriptor:	1,7,8,9,10,10-hexachloro-4-carboxypentyl-4-aza-tricyclo[5.2.1.0(2,6)]dec-8-ene-3,5-dione, Neutrophil gelatinase-associated lipocalin
Authors:	Skerra, A, Eichinger, A.
Deposit date:	2020-05-15
Release date:	2021-05-26
Last modified:	2024-01-24
Method:	X-RAY DIFFRACTION (1.8 Å)
Cite:	Structure of an engineered lipocalin that catalyzes a Diels-Alder reaction To be published

6Z6Z

Crystal structure of an Anticalin directed towards colchicine without ligand
Descriptor:	CALCIUM ION, Neutrophil gelatinase-associated lipocalin
Authors:	Skerra, A, Eichinger, A.
Deposit date:	2020-05-29
Release date:	2021-06-09
Last modified:	2024-10-16
Method:	X-RAY DIFFRACTION (1.78 Å)
Cite:	Structural rearrangement in the ligand pocket of Colchicalin upon Colchicine binding To be published

6ZVF

Crystal structure of the recombinant Fab fragment derived from the hybridoma M3/38 in complex with a human Galectin-3 peptide
Descriptor:	Chimeric Fab M3/38 (L,H), Galectin-3
Authors:	Skerra, A, Eichinger, A.
Deposit date:	2020-07-24
Release date:	2021-04-14
Last modified:	2024-01-31
Method:	X-RAY DIFFRACTION (1.9 Å)
Cite:	Effective rational humanization of a PASylated anti-galectin-3 Fab for the sensitive PET imaging of thyroid cancer in vivo. Sci Rep, 11, 2021

6GR0

Petrobactin-binding engineered lipocalin in complex with gallium-petrobactin
Descriptor:	4-[4-[3-[[3,4-bis(oxidanyl)phenyl]carbonylamino]propylamino]butylamino]-2-[2-[4-[3-[[3,4-bis(oxidanyl)phenyl]carbonylamino]propylamino]butylamino]-2-oxidanylidene-ethyl]-2-oxidanyl-4-oxidanylidene-butanoic acid, GALLIUM (III) ION, Neutrophil gelatinase-associated lipocalin
Authors:	Skerra, A, Eichinger, A.
Deposit date:	2018-06-08
Release date:	2018-08-15
Last modified:	2024-01-17
Method:	X-RAY DIFFRACTION (2.5 Å)
Cite:	Reprogramming Human Siderocalin To Neutralize Petrobactin, the Essential Iron Scavenger of Anthrax Bacillus. Angew. Chem. Int. Ed. Engl., 57, 2018

6GQZ

Petrobactin-binding engineered lipocalin without ligand
Descriptor:	Neutrophil gelatinase-associated lipocalin
Authors:	Skerra, A, Eichinger, A.
Deposit date:	2018-06-08
Release date:	2018-08-15
Last modified:	2024-01-17
Method:	X-RAY DIFFRACTION (1.4 Å)
Cite:	Reprogramming Human Siderocalin To Neutralize Petrobactin, the Essential Iron Scavenger of Anthrax Bacillus. Angew. Chem. Int. Ed. Engl., 57, 2018

6QBB

Engineered streptavidin variant (ENAGY) in complex with the Strep-tag II peptide
Descriptor:	Strep-tag II peptide, Streptavidin
Authors:	Skerra, A, Eichinger, A.
Deposit date:	2018-12-20
Release date:	2020-01-29
Last modified:	2024-01-24
Method:	X-RAY DIFFRACTION (1.52 Å)
Cite:	The Role of Changing Loop Conformations in Streptavidin Versions Engineered for High-affinity Binding of the Strep-tag II Peptide. J.Mol.Biol., 433, 2021

6QSY

Engineered streptavidin variant (H--WY) in complex with the Strep-tag II peptide
Descriptor:	2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, Strep-tag II peptide, Streptavidin, ...
Authors:	Skerra, A, Eichinger, A.
Deposit date:	2019-02-22
Release date:	2020-03-18
Last modified:	2024-01-24
Method:	X-RAY DIFFRACTION (1.7 Å)
Cite:	The Role of Changing Loop Conformations in Streptavidin Versions Engineered for High-affinity Binding of the Strep-tag II Peptide. J.Mol.Biol., 433, 2021

6QMU

A tetrahedral boronic acid diester formed by a non-natural amino acid in the ligand pocket of an engineered lipocalin
Descriptor:	3-nitrophenol, Neutrophil gelatinase-associated lipocalin
Authors:	Skerra, A, Eichinger, A.
Deposit date:	2019-02-08
Release date:	2019-08-28
Last modified:	2024-01-24
Method:	X-RAY DIFFRACTION (1.98 Å)
Cite:	A Tetrahedral Boronic Acid Diester Formed by an Unnatural Amino Acid in the Ligand Pocket of an Engineered Lipocalin. Chembiochem, 21, 2020

3P7F

Structure of the human Langerin carbohydrate recognition domain
Descriptor:	C-type lectin domain family 4 member K, CALCIUM ION
Authors:	Skerra, A, Schiefner, A.
Deposit date:	2010-10-12
Release date:	2010-11-03
Last modified:	2024-10-09
Method:	X-RAY DIFFRACTION (2.5 Å)
Cite:	The carbohydrate recognition domain of Langerin reveals high structural similarity with the one of DC-SIGN but an additional, calcium-independent sugar-binding site. Mol.Immunol., 45, 2008

3P7G

Structure of the human Langerin carbohydrate recognition domain in complex with mannose
Descriptor:	C-type lectin domain family 4 member K, CALCIUM ION, alpha-D-mannopyranose
Authors:	Skerra, A, Schiefner, A.
Deposit date:	2010-10-12
Release date:	2010-11-03
Last modified:	2024-10-30
Method:	X-RAY DIFFRACTION (1.5 Å)
Cite:	The carbohydrate recognition domain of Langerin reveals high structural similarity with the one of DC-SIGN but an additional, calcium-independent sugar-binding site. Mol.Immunol., 45, 2008

3P7H

Structure of the human Langerin carbohydrate recognition domain in complex with maltose
Descriptor:	C-type lectin domain family 4 member K, CALCIUM ION, alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose
Authors:	Skerra, A, Schiefner, A.
Deposit date:	2010-10-12
Release date:	2010-11-03
Last modified:	2024-10-30
Method:	X-RAY DIFFRACTION (2.3 Å)
Cite:	The carbohydrate recognition domain of Langerin reveals high structural similarity with the one of DC-SIGN but an additional, calcium-independent sugar-binding site. Mol.Immunol., 45, 2008

6QW4

Engineered streptavidin variant (ACGR) in complex with the Strep-tag II peptide
Descriptor:	Strep-tag II peptide, Streptavidin
Authors:	Skerra, A, Eichinger, A.
Deposit date:	2019-03-05
Release date:	2020-03-25
Last modified:	2024-01-24
Method:	X-RAY DIFFRACTION (2.1 Å)
Cite:	The Role of Changing Loop Conformations in Streptavidin Versions Engineered for High-affinity Binding of the Strep-tag II Peptide. J.Mol.Biol., 433, 2021

6SOK

Engineered streptavidin variant (VTAR) in complex with the Twin-Strep-tag peptide
Descriptor:	AMINO GROUP, Streptavidin, Twin-Strep-tag peptide
Authors:	Skerra, A, Eichinger, A.
Deposit date:	2019-08-29
Release date:	2020-09-09
Last modified:	2024-01-24
Method:	X-RAY DIFFRACTION (1.96 Å)
Cite:	The Role of Changing Loop Conformations in Streptavidin Versions Engineered for High-affinity Binding of the Strep-tag II Peptide. J.Mol.Biol., 433, 2021

6SOS

Engineered streptavidin variant (ENAGY) in complex with the Twin-Strep-tag peptide
Descriptor:	Streptavidin, Twin-Strep-tag peptide
Authors:	Skerra, A, Eichinger, A.
Deposit date:	2019-08-29
Release date:	2020-09-09
Last modified:	2024-01-24
Method:	X-RAY DIFFRACTION (2.2 Å)
Cite:	The Role of Changing Loop Conformations in Streptavidin Versions Engineered for High-affinity Binding of the Strep-tag II Peptide. J.Mol.Biol., 433, 2021

6TIP

Engineered streptavidin variant (YNAFM) in complex with the Strep-tag II peptide
Descriptor:	AMINO GROUP, Strep-tag II peptide, Streptavidin
Authors:	Skerra, A, Eichinger, A.
Deposit date:	2019-11-22
Release date:	2020-12-02
Last modified:	2024-01-24
Method:	X-RAY DIFFRACTION (2.1 Å)
Cite:	The Role of Changing Loop Conformations in Streptavidin Versions Engineered for High-affinity Binding of the Strep-tag II Peptide. J.Mol.Biol., 433, 2021

5MHH

Crystal structure of engineered human lipocalin 2 carrying p-boronophenylalanine at position 36
Descriptor:	Neutrophil gelatinase-associated lipocalin, SULFATE ION
Authors:	Skerra, A, Eichinger, A.
Deposit date:	2016-11-24
Release date:	2017-10-11
Last modified:	2024-10-16
Method:	X-RAY DIFFRACTION (2 Å)
Cite:	Rational Design of an Anticalin-Type Sugar-Binding Protein Using a Genetically Encoded Boronate Side Chain. ACS Synth Biol, 6, 2017

5NKN

Crystal structure of an Anticalin-colchicine complex
Descriptor:	N-[(7S)-1,2,3,10-tetramethoxy-9-oxo-6,7-dihydro-5H-benzo[d]heptalen-7-yl]ethanamide, Neutrophil gelatinase-associated lipocalin
Authors:	Skerra, A, Eichinger, A, Barkovskiy, M.
Deposit date:	2017-03-31
Release date:	2018-04-04
Last modified:	2024-10-23
Method:	X-RAY DIFFRACTION (2.2 Å)
Cite:	An engineered lipocalin that tightly complexes the plant poison colchicine for use as antidote and in bioanalytical applications. Biol. Chem., 400, 2019

5NBW

Crystal structure of the Fab fragment 22F12 in complex with 3-hydroxybenzo[a]pyrene
Descriptor:	Fab 22F12 (A,B), Fab 22F12 (L,H), benzo[a]pyren-3-ol
Authors:	Skerra, A, Eichinger, A.
Deposit date:	2017-03-02
Release date:	2017-06-28
Last modified:	2024-10-23
Method:	X-RAY DIFFRACTION (2.4 Å)
Cite:	Tight Molecular Recognition of Benzo[a]pyrene by a High-Affinity Antibody. Angew. Chem. Int. Ed. Engl., 56, 2017

3BX7

Engineered Human Lipocalin 2 (LCN2) in Complex with the Extracellular Domain of Human CTLA-4
Descriptor:	CYTOTOXIC T-LYMPHOCYTE-ASSOCIATED ANTIGEN 4, ENGINEERED HUMAN LIPOCALIN 2
Authors:	Schonfeld, D.L, Chatwell, L, Skerra, A.
Deposit date:	2008-01-11
Release date:	2009-01-20
Last modified:	2024-10-09
Method:	X-RAY DIFFRACTION (2.1 Å)
Cite:	High affinity molecular recognition and functional blockade of CTLA-4 by an engineered human lipocalin To be Published

1GPO

CRYSTAL STRUCTURE OF THE RATIONALLY DESIGNED ANTIBODY M41 AS A FAB FRAGMENT
Descriptor:	ANTIBODY M41, SULFATE ION
Authors:	Schiweck, W, Skerra, A.
Deposit date:	1997-03-27
Release date:	1998-04-01
Last modified:	2024-04-03
Method:	X-RAY DIFFRACTION (1.95 Å)
Cite:	The rational construction of an antibody against cystatin: lessons from the crystal structure of an artificial Fab fragment. J.Mol.Biol., 268, 1997

8B50

Crystal structure of a Fab fragment in complex with L-hydroxycoumarylalanine
Descriptor:	(2~{S})-2-azanyl-3-(7-oxidanyl-2-oxidanylidene-chromen-4-yl)propanoic acid, Fab fragment K12F9-22 - heavy chain, Fab fragment K12F9-22 - light chain, ...
Authors:	Meining, W, Eichinger, A, Skerra, A.
Deposit date:	2022-09-21
Release date:	2023-10-04
Method:	X-RAY DIFFRACTION (1.67 Å)
Cite:	Preparation and characterization of monoclonal antibodies against a non natural amino acid carrying the 7-hydroxycoumarin side chain To be published

1RST

COMPLEX BETWEEN STREPTAVIDIN AND THE STREP-TAG PEPTIDE
Descriptor:	STREP-TAG PEPTIDE, STREPTAVIDIN
Authors:	Koepke, J, Schmidt, T, Skerra, A.
Deposit date:	1995-10-19
Release date:	1997-05-15
Last modified:	2024-02-14
Method:	X-RAY DIFFRACTION (1.7 Å)
Cite:	Molecular interaction between the Strep-tag affinity peptide and its cognate target, streptavidin. J.Mol.Biol., 255, 1996

1RSU

COMPLEX BETWEEN STREPTAVIDIN AND THE STREP-TAG II PEPTIDE
Descriptor:	STREP-TAG II PEPTIDE, STREPTAVIDIN
Authors:	Koepke, J, Schmidt, T, Skerra, A.
Deposit date:	1995-10-19
Release date:	1997-05-15
Last modified:	2024-02-14
Method:	X-RAY DIFFRACTION (1.7 Å)
Cite:	Molecular interaction between the Strep-tag affinity peptide and its cognate target, streptavidin. J.Mol.Biol., 255, 1996

4MVL

Crystal structure of an engineered lipocalin (Anticalin H1GA) in complex with the Alzheimer amyloid peptide Abeta1-40
Descriptor:	Beta-amyloid protein 40, Neutrophil gelatinase-associated lipocalin
Authors:	Eichinger, A, Skerra, A.
Deposit date:	2013-09-24
Release date:	2015-08-12
Last modified:	2023-09-20
Method:	X-RAY DIFFRACTION (2.3 Å)
Cite:	High-affinity Anticalins with aggregation-blocking activity directed against the Alzheimer beta-amyloid peptide. Biochem.J., 473, 2016

4MVI

Crystal structure of an engineered lipocalin (Anticalin US7) in complex with the Alzheimer amyloid peptide Abeta(1-40)
Descriptor:	Beta-amyloid protein 40, Neutrophil gelatinase-associated lipocalin
Authors:	Eichinger, A, Skerra, A.
Deposit date:	2013-09-24
Release date:	2015-08-12
Last modified:	2023-09-20
Method:	X-RAY DIFFRACTION (1.7 Å)
Cite:	High-affinity Anticalins with aggregation-blocking activity directed against the Alzheimer beta-amyloid peptide. Biochem.J., 473, 2016

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Displayed results:	25
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