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2A5S
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BU of 2a5s by Molmil
Crystal Structure Of The NR2A Ligand Binding Core In Complex With Glutamate
Descriptor: GLUTAMIC ACID, N-methyl-D-aspartate receptor NMDAR2A subunit
Authors:Furukawa, H, Singh, S.K, Mancusso, R, Gouaux, E.
Deposit date:2005-06-30
Release date:2005-11-15
Last modified:2024-10-30
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Subunit arrangement and function in NMDA receptors
Nature, 438, 2005
2A5T
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BU of 2a5t by Molmil
Crystal Structure Of The NR1/NR2A ligand-binding cores complex
Descriptor: GLUTAMIC ACID, GLYCINE, N-methyl-D-aspartate receptor NMDAR1-4a subunit, ...
Authors:Furukawa, H, Singh, S.K, Mancusso, R, Gouaux, E.
Deposit date:2005-06-30
Release date:2005-11-15
Last modified:2017-07-26
Method:X-RAY DIFFRACTION (2 Å)
Cite:Subunit arrangement and function in NMDA receptors
Nature, 438, 2005
1PBQ
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BU of 1pbq by Molmil
CRYSTAL STRUCTURE OF THE NR1 LIGAND BINDING CORE IN COMPLEX WITH 5,7-DICHLOROKYNURENIC ACID (DCKA) AT 1.90 ANGSTROMS RESOLUTION
Descriptor: 5,7-DICHLORO-4-HYDROXYQUINOLINE-2-CARBOXYLIC ACID, N-methyl-D-aspartate Receptor Subunit 1
Authors:Furukawa, H, Gouaux, E.
Deposit date:2003-05-14
Release date:2003-07-29
Last modified:2020-07-15
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Mechanisms of activation, inhibition and specificity: crystal structures of the NMDA receptor NR1 ligand-binding core
Embo J., 22, 2003
1PB9
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BU of 1pb9 by Molmil
CRYSTAL STRUCTURE OF THE NR1 LIGAND BINDING CORE IN COMPLEX WITH D-CYCLOSERINE AT 1.60 ANGSTROMS RESOLUTION
Descriptor: (R)-4-AMINO-ISOXAZOLIDIN-3-ONE, N-methyl-D-aspartate Receptor Subunit 1
Authors:Furukawa, H, Gouaux, E.
Deposit date:2003-05-14
Release date:2003-06-24
Last modified:2024-10-30
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Mechanisms of activation, inhibition and specificity: crystal structures of the NMDA receptor NR1 ligand-binding core
Embo J., 22, 2003
1PB7
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BU of 1pb7 by Molmil
CRYSTAL STRUCTURE OF THE NR1 LIGAND BINDING CORE IN COMPLEX WITH GLYCINE AT 1.35 ANGSTROMS RESOLUTION
Descriptor: GLYCINE, N-methyl-D-aspartate Receptor Subunit 1
Authors:Furukawa, H, Gouaux, E.
Deposit date:2003-05-14
Release date:2003-06-24
Last modified:2024-10-30
Method:X-RAY DIFFRACTION (1.35 Å)
Cite:Mechanisms of activation, inhibition and specificity: crystal structures of the NMDA receptor NR1 ligand-binding core
Embo J., 22, 2003
1PB8
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BU of 1pb8 by Molmil
CRYSTAL STRUCTURE OF THE NR1 LIGAND BINDING CORE IN COMPLEX WITH D-SERINE AT 1.45 ANGSTROMS RESOLUTION
Descriptor: D-SERINE, N-methyl-D-aspartate Receptor Subunit 1
Authors:Furukawa, H, Gouaux, E.
Deposit date:2003-05-14
Release date:2003-06-24
Last modified:2017-07-26
Method:X-RAY DIFFRACTION (1.45 Å)
Cite:Mechanisms of activation, inhibition and specificity: crystal structures of the NMDA receptor NR1 ligand-binding core
Embo J., 22, 2003
6CNA
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BU of 6cna by Molmil
GluN1-GluN2B NMDA receptors with exon 5
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Glutamate receptor ionotropic, ...
Authors:Furukawa, H, Grant, T, Grigorieff, N.
Deposit date:2018-03-07
Release date:2018-10-03
Last modified:2024-10-23
Method:ELECTRON MICROSCOPY (4.6 Å)
Cite:Structural Mechanism of Functional Modulation by Gene Splicing in NMDA Receptors.
Neuron, 98, 2018
9BIB
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BU of 9bib by Molmil
Rat GluN1-GluN2B NMDA receptor channel in complex with glycine, glutamate, and EU-1622-A, in open-channel conformation, C1 symmetry
Descriptor: GLUTAMIC ACID, GLYCINE, Glutamate receptor, ...
Authors:Chou, T.-H, Furukawa, H.
Deposit date:2024-04-23
Release date:2024-07-31
Last modified:2024-10-30
Method:ELECTRON MICROSCOPY (3.81 Å)
Cite:Molecular mechanism of ligand gating and opening of NMDA receptor.
Nature, 632, 2024
2QTS
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BU of 2qts by Molmil
Structure of an acid-sensing ion channel 1 at 1.9 A resolution and low pH
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Acid-sensing ion channel, CHLORIDE ION, ...
Authors:Jasti, J, Furukawa, H, Gonzales, E.B, Gouaux, E.
Deposit date:2007-08-02
Release date:2007-09-25
Last modified:2024-10-30
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structure of acid-sensing ion channel 1 at 1.9A resolution and low pH
Nature, 449, 2007
8G18
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BU of 8g18 by Molmil
Heterodimer of the GluN1b-GluN2B NMDA receptor amino-terminal domains bound to allosteric inhibitor 93-108
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Glutamate receptor ionotropic, NMDA 1, ...
Authors:Regan, M.C, Furukawa, H.
Deposit date:2023-02-01
Release date:2023-03-01
Last modified:2024-10-30
Method:X-RAY DIFFRACTION (2.85 Å)
Cite:Novel GluN2B-Selective NMDA Receptor Negative Allosteric Modulator Possesses Intrinsic Analgesic Properties and Enhances Analgesia of Morphine in a Rodent Tail Flick Pain Model.
Acs Chem Neurosci, 14, 2023
8E96
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BU of 8e96 by Molmil
Glycine and glutamate bound Human GluN1a-GluN2D NMDA receptor
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, GLUTAMIC ACID, GLYCINE, ...
Authors:Kang, H, Furukawa, H.
Deposit date:2022-08-26
Release date:2022-12-07
Last modified:2022-12-14
Method:ELECTRON MICROSCOPY (3.38 Å)
Cite:Structural insights into assembly and function of GluN1-2C, GluN1-2A-2C, and GluN1-2D NMDARs.
Mol.Cell, 82, 2022
8E97
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BU of 8e97 by Molmil
PYD-106-bound Human GluN1a-GluN2C NMDA receptor in splayed conformation
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Glutamate receptor ionotropic, ...
Authors:Chou, T.-H, Furukawa, H.
Deposit date:2022-08-26
Release date:2022-12-07
Last modified:2024-10-30
Method:ELECTRON MICROSCOPY (4.19 Å)
Cite:Structural insights into assembly and function of GluN1-2C, GluN1-2A-2C, and GluN1-2D NMDARs.
Mol.Cell, 82, 2022
8E94
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BU of 8e94 by Molmil
PYD-106-bound Human GluN1a-GluN2C NMDA receptor in intact conformation
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Chou, T.-H, Furukawa, H.
Deposit date:2022-08-26
Release date:2022-12-07
Last modified:2022-12-14
Method:ELECTRON MICROSCOPY (3.72 Å)
Cite:Structural insights into assembly and function of GluN1-2C, GluN1-2A-2C, and GluN1-2D NMDARs.
Mol.Cell, 82, 2022
8E93
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BU of 8e93 by Molmil
D-cycloserine and glutamate bound Human GluN1a-GluN2C NMDA receptor in splayed conformation
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Glutamate receptor ionotropic, ...
Authors:Chou, T.-H, Furukawa, H.
Deposit date:2022-08-26
Release date:2022-12-07
Last modified:2024-10-16
Method:ELECTRON MICROSCOPY (3.71 Å)
Cite:Structural insights into assembly and function of GluN1-2C, GluN1-2A-2C, and GluN1-2D NMDARs.
Mol.Cell, 82, 2022
8E99
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BU of 8e99 by Molmil
Human GluN1a-GluN2A-GluN2C triheteromeric NMDA receptor in complex with Nb-4
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Glutamate receptor ionotropic, ...
Authors:Chou, T.-H, Furukawa, H.
Deposit date:2022-08-26
Release date:2022-12-07
Last modified:2022-12-14
Method:ELECTRON MICROSCOPY (4.24 Å)
Cite:Structural insights into assembly and function of GluN1-2C, GluN1-2A-2C, and GluN1-2D NMDARs.
Mol.Cell, 82, 2022
8E92
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BU of 8e92 by Molmil
D-cycloserine and glutamate bound Human GluN1a-GluN2C NMDA receptor in intact conformation
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Glutamate receptor ionotropic, ...
Authors:Chou, T.-H, Furukawa, H.
Deposit date:2022-08-26
Release date:2022-12-07
Last modified:2022-12-14
Method:ELECTRON MICROSCOPY (3.96 Å)
Cite:Structural insights into assembly and function of GluN1-2C, GluN1-2A-2C, and GluN1-2D NMDARs.
Mol.Cell, 82, 2022
8E98
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BU of 8e98 by Molmil
D-cycloserine and glutamate bound Human GluN1a-GluN2C NMDA receptor in nanodisc - intact conformation
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Glutamate receptor ionotropic, NMDA 1, ...
Authors:Chou, T.-H, Furukawa, H.
Deposit date:2022-08-26
Release date:2022-12-07
Last modified:2022-12-14
Method:ELECTRON MICROSCOPY (3.75 Å)
Cite:Structural insights into assembly and function of GluN1-2C, GluN1-2A-2C, and GluN1-2D NMDARs.
Mol.Cell, 82, 2022
8S90
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BU of 8s90 by Molmil
Cryo-EM structure of octameric human CALHM1 (I109W) in complex with ruthenium red (C1)
Descriptor: Calcium homeostasis modulator protein 1, ruthenium(6+) azanide pentaamino(oxido)ruthenium (1/4/2)
Authors:Syrjanen, J.L, Furukawa, H.
Deposit date:2023-03-27
Release date:2023-07-26
Last modified:2024-05-01
Method:ELECTRON MICROSCOPY (4.73 Å)
Cite:Structure of human CALHM1 reveals key locations for channel regulation and blockade by ruthenium red.
Nat Commun, 14, 2023
8S8Z
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BU of 8s8z by Molmil
Cryo-EM structure of octameric human CALHM1 (I109W) in complex with ruthenium red
Descriptor: (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, Calcium homeostasis modulator protein 1, ruthenium(6+) azanide pentaamino(oxido)ruthenium (1/4/2)
Authors:Syrjanen, J.L, Furukawa, H.
Deposit date:2023-03-27
Release date:2023-07-26
Last modified:2024-05-01
Method:ELECTRON MICROSCOPY (3.91 Å)
Cite:Structure of human CALHM1 reveals key locations for channel regulation and blockade by ruthenium red.
Nat Commun, 14, 2023
6E7R
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BU of 6e7r by Molmil
Heterodimer of the GluN1b-GluN2B NMDA receptor amino-terminal domains bound to allosteric inhibitor 93-4
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CHLORIDE ION, ...
Authors:Regan, M.C, Furukawa, H.
Deposit date:2018-07-27
Release date:2019-01-30
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structural elements of a pH-sensitive inhibitor binding site in NMDA receptors
Nat Commun, 10, 2019
9ARI
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BU of 9ari by Molmil
Rat GluN1-GluN2B NMDA receptor channel in complex with glutamate
Descriptor: GLUTAMIC ACID, Glutamate receptor ionotropic, NMDA 2B, ...
Authors:Chou, T.-H, Furukawa, H.
Deposit date:2024-02-23
Release date:2024-07-31
Last modified:2024-08-14
Method:ELECTRON MICROSCOPY (3.9 Å)
Cite:Molecular mechanism of ligand gating and opening of NMDA receptor.
Nature, 632, 2024
9ARG
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BU of 9arg by Molmil
Rat GluN1-GluN2B NMDA receptor channel in apo conformation
Descriptor: Glutamate receptor ionotropic, NMDA 1, NMDA 2B
Authors:Chou, T.-H, Furukawa, H.
Deposit date:2024-02-23
Release date:2024-07-31
Last modified:2024-08-14
Method:ELECTRON MICROSCOPY (4.05 Å)
Cite:Molecular mechanism of ligand gating and opening of NMDA receptor.
Nature, 632, 2024
9ARH
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BU of 9arh by Molmil
Rat GluN1-GluN2B NMDA receptor channel in complex with glycine
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, GLYCINE, ...
Authors:Chou, T.-H, Furukawa, H.
Deposit date:2024-02-23
Release date:2024-07-31
Last modified:2024-10-30
Method:ELECTRON MICROSCOPY (3.69 Å)
Cite:Molecular mechanism of ligand gating and opening of NMDA receptor.
Nature, 632, 2024
9ARE
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BU of 9are by Molmil
Rat GluN1-GluN2B NMDA receptor channel in complex with glycine, glutamate, and EU-1622-A, in open-channel conformation
Descriptor: GLUTAMIC ACID, GLYCINE, Glutamate receptor ionotropic, ...
Authors:Chou, T.-H, Furukawa, H.
Deposit date:2024-02-23
Release date:2024-07-31
Last modified:2024-10-23
Method:ELECTRON MICROSCOPY (3.72 Å)
Cite:Molecular mechanism of ligand gating and opening of NMDA receptor.
Nature, 632, 2024
9ARF
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BU of 9arf by Molmil
Rat GluN1-GluN2B NMDA receptor channel in complex with glycine, glutamate, and EU-1622-A, in nonactive1 conformation
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, GLUTAMIC ACID, ...
Authors:Chou, T.-H, Furukawa, H.
Deposit date:2024-02-23
Release date:2024-07-31
Last modified:2024-10-23
Method:ELECTRON MICROSCOPY (3.13 Å)
Cite:Molecular mechanism of ligand gating and opening of NMDA receptor.
Nature, 632, 2024

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数据于2024-10-30公开中

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