1A3C
| PYRR, THE BACILLUS SUBTILIS PYRIMIDINE BIOSYNTHETIC OPERON REPRESSOR, DIMERIC FORM | Descriptor: | PYRIMIDINE OPERON REGULATORY PROTEIN PYRR, SAMARIUM (III) ION, SULFATE ION | Authors: | Tomchick, D.R, Turner, R.J, Switzer, R.W, Smith, J.L. | Deposit date: | 1998-01-20 | Release date: | 1998-08-05 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | Adaptation of an enzyme to regulatory function: structure of Bacillus subtilis PyrR, a pyr RNA-binding attenuation protein and uracil phosphoribosyltransferase. Structure, 6, 1998
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1A4X
| PYRR, THE BACILLUS SUBTILIS PYRIMIDINE BIOSYNTHETIC OPERON REPRESSOR, HEXAMERIC FORM | Descriptor: | PYRIMIDINE OPERON REGULATORY PROTEIN PYRR, SULFATE ION | Authors: | Tomchick, D.R, Turner, R.J, Switzer, R.W, Smith, J.L. | Deposit date: | 1998-02-08 | Release date: | 1998-08-05 | Last modified: | 2024-05-22 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Adaptation of an enzyme to regulatory function: structure of Bacillus subtilis PyrR, a pyr RNA-binding attenuation protein and uracil phosphoribosyltransferase. Structure, 6, 1998
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1FGT
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1F8N
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1FGM
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1FGQ
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1FGR
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1FGO
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9B8D
| Structure of Legionella pneumophila Ceg10 | Descriptor: | 1,2-ETHANEDIOL, Ceg10, PHOSPHATE ION | Authors: | Tomchick, D.R, Heisler, D.B, Alto, N.M. | Deposit date: | 2024-03-29 | Release date: | 2024-04-10 | Last modified: | 2024-05-29 | Method: | X-RAY DIFFRACTION (1.72 Å) | Cite: | Exploiting bacterial effector proteins to uncover evolutionarily conserved antiviral host machinery. Plos Pathog., 20, 2024
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9B8E
| Structure of S-nitrosylated Legionella pneumophila Ceg10. | Descriptor: | 1,2-ETHANEDIOL, ACETATE ION, CHLORIDE ION, ... | Authors: | Tomchick, D.R, Heisler, D.B, Alto, N.M. | Deposit date: | 2024-03-29 | Release date: | 2024-04-10 | Last modified: | 2024-05-29 | Method: | X-RAY DIFFRACTION (1.4 Å) | Cite: | Exploiting bacterial effector proteins to uncover evolutionarily conserved antiviral host machinery. Plos Pathog., 20, 2024
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8DML
| Vibrio parahaemolyticus VtrA/VtrC complex bound to the bile salt chenodeoxycholate | Descriptor: | 1,2-ETHANEDIOL, CALCIUM ION, CHENODEOXYCHOLIC ACID, ... | Authors: | Tomchick, D.R, Orth, K, Zou, A.J. | Deposit date: | 2022-07-08 | Release date: | 2023-06-14 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (2.08 Å) | Cite: | Molecular determinants for differential activation of the bile acid receptor from the pathogen Vibrio parahaemolyticus. J.Biol.Chem., 299, 2023
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4DBB
| The PTB domain of Mint1 is autoinhibited by a helix in the C-terminal linker region | Descriptor: | ACETIC ACID, Amyloid beta A4 precursor protein-binding family A member 1, CHLORIDE ION, ... | Authors: | Tomchick, D.R, Rizo, J, Ho, A, Xu, Y. | Deposit date: | 2012-01-13 | Release date: | 2012-03-07 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (1.901 Å) | Cite: | Autoinhibition of Mint1 adaptor protein regulates amyloid precursor protein binding and processing. Proc.Natl.Acad.Sci.USA, 109, 2012
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6NYT
| Munc13-1 C2B-domain, calcium bound | Descriptor: | CALCIUM ION, CHLORIDE ION, GLYCEROL, ... | Authors: | Tomchick, D.R, Rizo, J, Machius, M, Lu, J. | Deposit date: | 2019-02-12 | Release date: | 2019-02-20 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (1.369 Å) | Cite: | Munc13 C2B domain is an activity-dependent Ca2+ regulator of synaptic exocytosis. Nat. Struct. Mol. Biol., 17, 2010
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5EW4
| Crystal structure of C9ORF72 Antisense CCCCGG repeat RNA associated with Lou Gehrig's disease and frontotemporal dementia, crystallized with Sr2+ | Descriptor: | CHLORIDE ION, MAGNESIUM ION, POTASSIUM ION, ... | Authors: | Tomchick, D.R, Dodd, D.W, Gagnon, K.T, Corey, D.R. | Deposit date: | 2015-11-20 | Release date: | 2016-02-24 | Last modified: | 2024-03-06 | Method: | X-RAY DIFFRACTION (1.47 Å) | Cite: | Pathogenic C9ORF72 Antisense Repeat RNA Forms a Double Helix with Tandem C:C Mismatches. Biochemistry, 55, 2016
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5EW7
| Crystal structure of C9ORF72 Antisense CCCCGG repeat RNA associated with Lou Gehrig's disease and frontotemporal dementia, crystallized with Ba2+ | Descriptor: | BARIUM ION, MAGNESIUM ION, POTASSIUM ION, ... | Authors: | Tomchick, D.R, Dodd, D.W, Gagnon, K.T, Corey, D.R. | Deposit date: | 2015-11-20 | Release date: | 2016-02-24 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (1.75 Å) | Cite: | Pathogenic C9ORF72 Antisense Repeat RNA Forms a Double Helix with Tandem C:C Mismatches. Biochemistry, 55, 2016
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3BEN
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6ANJ
| Synaptotagmin-7, C2A domain | Descriptor: | ACETATE ION, CALCIUM ION, Synaptotagmin-7, ... | Authors: | Tomchick, D.R, Rizo, J, Voleti, R. | Deposit date: | 2017-08-13 | Release date: | 2017-09-20 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (1.698 Å) | Cite: | Exceptionally tight membrane-binding may explain the key role of the synaptotagmin-7 C2A domain in asynchronous neurotransmitter release. Proc. Natl. Acad. Sci. U.S.A., 114, 2017
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6ANK
| Synaptotagmin-7, C2A- and C2B-domains | Descriptor: | 1,2-ETHANEDIOL, CALCIUM ION, Synaptotagmin-7 | Authors: | Tomchick, D.R, Rizo, J, Voleti, R. | Deposit date: | 2017-08-13 | Release date: | 2017-09-20 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (2.254 Å) | Cite: | Exceptionally tight membrane-binding may explain the key role of the synaptotagmin-7 C2A domain in asynchronous neurotransmitter release. Proc. Natl. Acad. Sci. U.S.A., 114, 2017
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6AO5
| Crystal structure of human MST2 in complex with SAV1 SARAH domain | Descriptor: | MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, Protein salvador homolog 1, ... | Authors: | Tomchick, D.R, Luo, X, Ni, L. | Deposit date: | 2017-08-15 | Release date: | 2017-11-08 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (2.955 Å) | Cite: | SAV1 promotes Hippo kinase activation through antagonizing the PP2A phosphatase STRIPAK. Elife, 6, 2017
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6DFT
| Trypanosoma brucei deoxyhypusine synthase | Descriptor: | Deoxyhypusine synthase, Deoxyhypusine synthase regulatory subunit, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, ... | Authors: | Tomchick, D.R, Phillips, M.A, Afanador, G.A. | Deposit date: | 2018-05-15 | Release date: | 2018-08-08 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (3.5 Å) | Cite: | Trypanosomatid Deoxyhypusine Synthase Activity Is Dependent on Shared Active-Site Complementation between Pseudoenzyme Paralogs. Structure, 26, 2018
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6E0B
| Plasmodium falciparum dihydroorotate dehydrogenase C276F mutant bound with triazolopyrimidine-based inhibitor DSM1 | Descriptor: | 5-methyl-7-(naphthalen-2-ylamino)-1H-[1,2,4]triazolo[1,5-a]pyrimidine-3,8-diium, Dihydroorotate dehydrogenase (quinone), mitochondrial, ... | Authors: | Tomchick, D.R, Phillips, M.A, Deng, X. | Deposit date: | 2018-07-06 | Release date: | 2018-11-14 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (2.099 Å) | Cite: | Identification and Mechanistic Understanding of Dihydroorotate Dehydrogenase Point Mutations in Plasmodium falciparum that Confer in Vitro Resistance to the Clinical Candidate DSM265. ACS Infect Dis, 5, 2019
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6EAC
| Pseudomonas syringae SelO | Descriptor: | 1,2-ETHANEDIOL, ACETATE ION, CALCIUM ION, ... | Authors: | Tomchick, D.R, Tagliabracci, V.S, Sreelatha, A. | Deposit date: | 2018-08-02 | Release date: | 2018-10-03 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (2.269 Å) | Cite: | Protein AMPylation by an Evolutionarily Conserved Pseudokinase. Cell, 175, 2018
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1AO0
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5KEV
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5KEW
| Vibrio parahaemolyticus VtrA/VtrC complex bound to the bile salt taurodeoxycholate | Descriptor: | 1,2-ETHANEDIOL, ACETATE ION, SULFATE ION, ... | Authors: | Tomchick, D.R, Orth, K, Rivera-Cancel, G. | Deposit date: | 2016-06-10 | Release date: | 2016-07-20 | Last modified: | 2024-03-06 | Method: | X-RAY DIFFRACTION (2.103 Å) | Cite: | Bile salt receptor complex activates a pathogenic type III secretion system. Elife, 5, 2016
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