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7EXT
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BU of 7ext by Molmil
Cryo-EM structure of cyanobacterial phycobilisome from Synechococcus sp. PCC 7002
Descriptor: Allophycocyanin alpha subunit, Allophycocyanin beta subunit, Allophycocyanin subunit alpha-B, ...
Authors:Zheng, L, Zheng, Z, Li, X, Wang, G, Zhang, K, Wei, P, Zhao, J, Gao, N.
Deposit date:2021-05-28
Release date:2021-10-06
Method:ELECTRON MICROSCOPY (3.5 Å)
Cite:Structural insight into the mechanism of energy transfer in cyanobacterial phycobilisomes.
Nat Commun, 12, 2021
7EYD
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BU of 7eyd by Molmil
Cryo-EM structure of cyanobacterial phycobilisome from Anabaena sp. PCC 7120
Descriptor: Allophycocyanin subunit alpha 1, Allophycocyanin subunit alpha-B, Allophycocyanin subunit beta, ...
Authors:Zheng, L, Zheng, Z, Li, X, Wang, G, Zhang, K, Wei, P, Zhao, J, Gao, N.
Deposit date:2021-05-30
Release date:2021-10-06
Method:ELECTRON MICROSCOPY (3.9 Å)
Cite:Structural insight into the mechanism of energy transfer in cyanobacterial phycobilisomes.
Nat Commun, 12, 2021
5UFK
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BU of 5ufk by Molmil
Structure of the effector protein SidK (lpg0968) from Legionella pneumophila
Descriptor: GLYCEROL, effector protein SidK
Authors:Beyrakhova, K, Xu, C, Boniecki, M.T, Cygler, M.
Deposit date:2017-01-04
Release date:2017-05-10
Last modified:2020-01-08
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Molecular basis for the binding and modulation of V-ATPase by a bacterial effector protein.
PLoS Pathog., 13, 2017
5UF5
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BU of 5uf5 by Molmil
Structure of the effector protein SidK (lpg0968) from Legionella pneumophila (domain-swapped dimer)
Descriptor: GLYCEROL, effector protein SidK
Authors:Beyrakhova, K, Xu, C, Boniecki, M.T, Cygler, M.
Deposit date:2017-01-03
Release date:2017-05-10
Last modified:2024-03-06
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Molecular basis for the binding and modulation of V-ATPase by a bacterial effector protein.
PLoS Pathog., 13, 2017
6TYY
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BU of 6tyy by Molmil
Hedgehog autoprocessing mutant D46H
Descriptor: Protein hedgehog
Authors:Li, H, Li, Z, Wang, C, Callahan, B.P.
Deposit date:2019-08-09
Release date:2019-11-20
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (1.36 Å)
Cite:General Base Swap Preserves Activity and Expands Substrate Tolerance in Hedgehog Autoprocessing.
J.Am.Chem.Soc., 141, 2019
4FH7
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BU of 4fh7 by Molmil
Structure of DHP A in complex with 2,4,6-tribromophenol in 20% methanol
Descriptor: 2,4,6-TRIBROMOPHENOL, Dehaloperoxidase A, METHANOL, ...
Authors:de Serrano, V.S, Franzen, S.
Deposit date:2012-06-05
Release date:2013-03-27
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (1.74 Å)
Cite:Structural and Kinetic Study of an Internal Substrate Binding Site in Dehaloperoxidase-Hemoglobin A from Amphitrite ornata.
Biochemistry, 52, 2013
4FH6
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BU of 4fh6 by Molmil
Structure of DHP A in complex with 2,4,6-tribromophenol in 10% DMSO
Descriptor: 2,4,6-TRIBROMOPHENOL, DIMETHYL SULFOXIDE, Dehaloperoxidase A, ...
Authors:de Serrano, V.S, Franzen, S.
Deposit date:2012-06-05
Release date:2013-03-27
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (1.44 Å)
Cite:Structural and Kinetic Study of an Internal Substrate Binding Site in Dehaloperoxidase-Hemoglobin A from Amphitrite ornata.
Biochemistry, 52, 2013
6GMI
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BU of 6gmi by Molmil
Genetic Engineering of an Artificial Metalloenzyme for Transfer Hydrogenation of a Self-Immolative Substrate in E. coli's Periplasm.
Descriptor: IRIDIUM (III) ION, Streptavidin, {N-(4-{[2-(amino-kappaN)ethyl]sulfamoyl-kappaN}phenyl)-5-[(3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl]pentanamide}(chloro)[(1,2,3,4,5-eta)-1,2,3,4,5-pentamethylcyclopentadienyl]iridium(III)
Authors:Rebelein, J.G.
Deposit date:2018-05-26
Release date:2018-10-10
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Genetic Engineering of an Artificial Metalloenzyme for Transfer Hydrogenation of a Self-Immolative Substrate in Escherichia coli's Periplasm.
J. Am. Chem. Soc., 140, 2018
3RDH
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BU of 3rdh by Molmil
X-ray induced covalent inhibition of 14-3-3
Descriptor: 14-3-3 protein zeta/delta, 4-[(E)-{4-formyl-5-hydroxy-6-methyl-3-[(phosphonooxy)methyl]pyridin-2-yl}diazenyl]benzoic acid, NICKEL (II) ION
Authors:Horton, J.R, Upadhyay, A.K, Fu, H, Cheng, X.
Deposit date:2011-04-01
Release date:2011-09-28
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (2.39 Å)
Cite:Discovery and structural characterization of a small molecule 14-3-3 protein-protein interaction inhibitor.
Proc.Natl.Acad.Sci.USA, 108, 2011
4U5T
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BU of 4u5t by Molmil
Crystal Structure of VBP Leucine Zipper with Bound Arylstibonic Acid
Descriptor: (2Z)-3-{3-[dihydroxy(oxido)-lambda~5~-stibanyl]phenyl}prop-2-enoic acid, VBP leucine zipper
Authors:Stagno, J.R, Ji, X.
Deposit date:2014-07-25
Release date:2014-08-06
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (3.301 Å)
Cite:P6981, an arylstibonic acid, is a novel low nanomolar inhibitor of cAMP response element-binding protein binding to DNA.
Mol.Pharmacol., 82, 2012
8E4A
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BU of 8e4a by Molmil
Pseudomonas LpxC in complex with LPC-233
Descriptor: 4-(4-cyclopropylbuta-1,3-diyn-1-yl)-N-[(2S,3S)-4,4-difluoro-3-hydroxy-1-(hydroxyamino)-3-methyl-1-oxobutan-2-yl]benzamide, UDP-3-O-acyl-N-acetylglucosamine deacetylase, ZINC ION
Authors:Najeeb, J, Zhou, P.
Deposit date:2022-08-17
Release date:2023-08-23
Method:X-RAY DIFFRACTION (2.034 Å)
Cite:Preclinical safety and efficacy characterization of an LpxC inhibitor against Gram-negative pathogens.
Sci Transl Med, 15, 2023
6EBU
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BU of 6ebu by Molmil
Crystal structure of Aquifex aeolicus LpxE
Descriptor: LpxE, SULFATE ION, octyl beta-D-glucopyranoside
Authors:Wu, Q, Wang, S, Zhou, P.
Deposit date:2018-08-07
Release date:2019-06-26
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (2.372 Å)
Cite:The Lipid A 1-Phosphatase, LpxE, Functionally Connects Multiple Layers of Bacterial Envelope Biogenesis.
Mbio, 10, 2019
6C14
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BU of 6c14 by Molmil
CryoEM structure of mouse PCDH15-1EC-LHFPL5 complex
Descriptor: LHFPL tetraspan subfamily member 5 protein, Protocadherin-15
Authors:Gouaux, E, Elferich, J, Ge, J.
Deposit date:2018-01-03
Release date:2018-08-15
Last modified:2019-12-18
Method:ELECTRON MICROSCOPY (4.5 Å)
Cite:Structure of mouse protocadherin 15 of the stereocilia tip link in complex with LHFPL5.
Elife, 7, 2018
6J9D
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BU of 6j9d by Molmil
Babesia microti lactate dehydrogenase R99A (BmLDHR99A)
Descriptor: L-lactate dehydrogenase
Authors:Yu, L.
Deposit date:2019-01-22
Release date:2019-10-16
Last modified:2024-03-27
Method:X-RAY DIFFRACTION (2.904 Å)
Cite:Crystal structures ofBabesia microtilactate dehydrogenase BmLDH reveal a critical role for Arg99 in catalysis.
Faseb J., 33, 2019
6CEO
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BU of 6ceo by Molmil
Structure of Hsp90 NTD with a GRP94-selective resorcinylic inhibitor.
Descriptor: 1,2-ETHANEDIOL, Heat shock protein HSP 90-alpha, MAGNESIUM ION, ...
Authors:Que, N.L.S, Gewirth, D.T.
Deposit date:2018-02-12
Release date:2018-04-18
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (1.896 Å)
Cite:Structure Based Design of a Grp94-Selective Inhibitor: Exploiting a Key Residue in Grp94 To Optimize Paralog-Selective Binding.
J. Med. Chem., 61, 2018
4MK7
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BU of 4mk7 by Molmil
Hepatitis C Virus polymerase NS5B genotype 1b (BK) in complex with inhibitor 2 (3-(3-tert-butyl-4-methoxyphenyl)pyridin-2(1H)-one)
Descriptor: 3-(3-tert-butyl-4-methoxyphenyl)pyridin-2(1H)-one, DIMETHYL SULFOXIDE, MAGNESIUM ION, ...
Authors:Harris, S.F, Wong, A.
Deposit date:2013-09-04
Release date:2013-10-09
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Discovery of a Novel Series of Potent Non-Nucleoside Inhibitors of Hepatitis C Virus NS5B.
J.Med.Chem., 56, 2013
4MK8
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BU of 4mk8 by Molmil
Hepatitis C Virus polymerase NS5B genotype 1b (BK) in complex with inhibitor 4 (N-(4-{2-[3-tert-butyl-2-methoxy-5-(2-oxo-1,2-dihydropyridin-3-yl)phenyl]ethyl}phenyl)methanesulfonamide)
Descriptor: DIMETHYL SULFOXIDE, GLYCEROL, N-(4-{2-[3-tert-butyl-2-methoxy-5-(2-oxo-1,2-dihydropyridin-3-yl)phenyl]ethyl}phenyl)methanesulfonamide, ...
Authors:Harris, S.F, Wong, A.
Deposit date:2013-09-04
Release date:2013-10-09
Last modified:2014-01-15
Method:X-RAY DIFFRACTION (2.09 Å)
Cite:Discovery of a Novel Series of Potent Non-Nucleoside Inhibitors of Hepatitis C Virus NS5B.
J.Med.Chem., 56, 2013
4MKB
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BU of 4mkb by Molmil
Hepatitis C Virus polymerase NS5B genotype 1b (BK) in complex with inhibitor 14 (N-(4-{(E)-2-[3-tert-butyl-2-methoxy-5-(3-oxo-2,3-dihydropyridazin-4-yl)phenyl]ethenyl}phenyl)methanesulfonamide)
Descriptor: N-(4-{(E)-2-[3-tert-butyl-2-methoxy-5-(3-oxo-2,3-dihydropyridazin-4-yl)phenyl]ethenyl}phenyl)methanesulfonamide, RNA-DIRECTED RNA POLYMERASE
Authors:Harris, S.F, Wong, A.
Deposit date:2013-09-04
Release date:2013-10-09
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Discovery of a Novel Series of Potent Non-Nucleoside Inhibitors of Hepatitis C Virus NS5B.
J.Med.Chem., 56, 2013
4MK9
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BU of 4mk9 by Molmil
Hepatitis C Virus polymerase NS5B genotype 1b (BK) in complex with inhibitor 12 (N-{2-[3-tert-butyl-2-methoxy-5-(2-oxo-1,2-dihydropyridin-3-yl)phenyl]-1,3-benzoxazol-5-yl}methanesulfonamide)
Descriptor: GLYCEROL, N-{2-[3-tert-butyl-2-methoxy-5-(2-oxo-1,2-dihydropyridin-3-yl)phenyl]-1,3-benzoxazol-5-yl}methanesulfonamide, RNA-DIRECTED RNA POLYMERASE
Authors:Harris, S.F, Wong, A.
Deposit date:2013-09-04
Release date:2013-10-09
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:Discovery of a Novel Series of Potent Non-Nucleoside Inhibitors of Hepatitis C Virus NS5B.
J.Med.Chem., 56, 2013
6PH9
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BU of 6ph9 by Molmil
Crystal Structure of the Klebsiella pneumoniae LpxH-lipid X complex
Descriptor: (R)-((2R,3S,4R,5R,6R)-3-HYDROXY-2-(HYDROXYMETHYL)-5-((R)-3-HYDROXYTETRADECANAMIDO)-6-(PHOSPHONOOXY)TETRAHYDRO-2H-PYRAN-4-YL) 3-HYDROXYTETRADECANOATE, 1,2-ETHANEDIOL, CALCIUM ION, ...
Authors:Cho, J, Zhou, P.
Deposit date:2019-06-25
Release date:2020-02-12
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (1.92 Å)
Cite:Structural basis of the UDP-diacylglucosamine pyrophosphohydrolase LpxH inhibition by sulfonyl piperazine antibiotics.
Proc.Natl.Acad.Sci.USA, 117, 2020
6PJ3
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BU of 6pj3 by Molmil
Crystal structure of the Klebsiella pneumoniae LpxH/JH-LPH-33 complex
Descriptor: 1,2-ETHANEDIOL, 1-[5-({4-[3-chloro-5-(trifluoromethyl)phenyl]piperazin-1-yl}sulfonyl)-2,3-dihydro-1H-indol-1-yl]ethan-1-one, MANGANESE (II) ION, ...
Authors:Cho, J, Zhou, P.
Deposit date:2019-06-27
Release date:2020-02-12
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:Structural basis of the UDP-diacylglucosamine pyrophosphohydrolase LpxH inhibition by sulfonyl piperazine antibiotics.
Proc.Natl.Acad.Sci.USA, 117, 2020
7F5W
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BU of 7f5w by Molmil
Conserved and divergent strigolactone signaling in Saccharum spontaneum
Descriptor: High tillering and dwarf 2 protein
Authors:Zhao, Q.Q, Ming, Z.H.
Deposit date:2021-06-23
Release date:2022-05-04
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (1.654 Å)
Cite:Identification of Conserved and Divergent Strigolactone Receptors in Sugarcane Reveals a Key Residue Crucial for Plant Branching Control.
Front Plant Sci, 12, 2021
5E00
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BU of 5e00 by Molmil
Structure of HLA-A2 P130
Descriptor: Beta-2-microglobulin, GLY-VAL-TRP-ILE-ARG-THR-PRO-PRO-ALA, HLA class I histocompatibility antigen, ...
Authors:Zhang, Y, Wu, Y, Qi, J, Liu, J, Gao, G.F, Meng, S.
Deposit date:2015-09-26
Release date:2017-01-18
Last modified:2019-01-23
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:CD8+T-Cell Response-Associated Evolution of Hepatitis B Virus Core Protein and Disease Progress.
J. Virol., 92, 2018
3CDE
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BU of 3cde by Molmil
Crystal structure of HCV NS5B polymerase with a novel Pyridazinone inhibitor
Descriptor: N-{3-[5-hydroxy-2-(3-methylbutyl)-3-oxo-6-thiophen-2-yl-2,3-dihydropyridazin-4-yl]-1,1-dioxido-2H-1,2,4-benzothiadiazin-7-yl}methanesulfonamide, RNA-directed RNA polymerase
Authors:Zhao, Q, Showalter, R.E, Han, Q, Kissinger, C.R.
Deposit date:2008-02-26
Release date:2009-03-03
Last modified:2024-04-03
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Novel HCV NS5B polymerase inhibitors derived from 4-(1',1'-dioxo-1',4'-dihydro-1'lambda(6)-benzo[1',2',4']thiadiazin-3'-yl)-5-hydroxy-2H-pyridazin-3-ones. Part 3: Further optimization of the 2-, 6-, and 7'-substituents and initial pharmacokinetic assessments.
Bioorg.Med.Chem.Lett., 18, 2008
7JUO
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BU of 7juo by Molmil
CBP bromodomain complexed with YF2-23
Descriptor: CREB-binding protein, N-{1-[1,1-di(pyridin-2-yl)ethyl]-6-(1-methyl-7-oxo-6,7-dihydro-1H-pyrrolo[2,3-c]pyridin-3-yl)-1H-indol-4-yl}ethanesulfonamide
Authors:Ratia, K.M, Xiong, R, Principe, D, Li, Y, Huang, F, Rana, A, Thatcher, G.
Deposit date:2020-08-20
Release date:2021-09-01
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:XP-524 is a dual-BET/EP300 inhibitor that represses oncogenic KRAS and potentiates immune checkpoint inhibition in pancreatic cancer.
Proc.Natl.Acad.Sci.USA, 119, 2022

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数据于2024-06-26公开中

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