2N4H

Solution Structure of the Q343R Mutant of TDP-43 Amyloidogenic Core Region

Summary for 2N4H

• Entry DOI: 10.2210/pdb2n4h/pdb
• Related: 2N3X 2N4G
• NMR Information: BMRB: 25668
• Descriptor: TAR DNA-binding protein 43 (1 entity in total)
• Functional Keywords: tdp-43, amyloidogenic core region, q343r, dna binding protein
• Biological source: Homo sapiens (human)
• Cellular location: Nucleus : Q13148
• Total number of polymer chains: 1
• Total formula weight: 5236.86

Authors

Jiang, L.,Zhao, J.,Hu, H. (deposition date: 2015-06-18, release date: 2016-04-20, Last modification date: 2023-06-14)

• Primary citation: Jiang, L.L.,Zhao, J.,Yin, X.F.,He, W.T.,Yang, H.,Che, M.X.,Hu, H.Y.; Two mutations G335D and Q343R within the amyloidogenic core region of TDP-43 influence its aggregation and inclusion formation; Sci Rep, 6:23928-23928, 2016; PubMed: 27030292; DOI: 10.1038/srep23928

Experimental method

SOLUTION NMR