8P45
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![BU of 8p45 by Molmil](/molmil-images/mine/8p45) | Crystal structure of human STING in complex with the agonist MD1202D | Descriptor: | 9-[(1~{S},3~{R},6~{R},8~{R},9~{R},10~{R},12~{R},15~{R},17~{R},18~{R})-8-(6-aminopurin-9-yl)-9,18-bis(fluoranyl)-3,12-bis(oxidanylidene)-3,12-bis(sulfanyl)-2,4,7,11,13-pentaoxa-3$l^{5},12$l^{5}-diphosphatricyclo[13.2.1.0^{6,10}]octadecan-17-yl]-1~{H}-purin-6-one, Stimulator of interferon genes protein | Authors: | Klima, M, Boura, E. | Deposit date: | 2023-05-19 | Release date: | 2023-12-20 | Last modified: | 2024-04-17 | Method: | X-RAY DIFFRACTION (3.23 Å) | Cite: | Fluorinated cGAMP analogs, which act as STING agonists and are not cleavable by poxins: Structural basis of their function. Structure, 32, 2024
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8ORV
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![BU of 8orv by Molmil](/molmil-images/mine/8orv) | Crystal structure of monkeypox virus poxin in complex with the STING agonist MD1203 | Descriptor: | 9-[(1~{S},6~{R},8~{R},9~{R},10~{R},15~{R},17~{R},18~{R})-8-(6-aminopurin-9-yl)-9,18-bis(fluoranyl)-3,12-bis(oxidanyl)-3,12-bis(oxidanylidene)-2,4,7,11,13-pentaoxa-3$l^{5},12$l^{5}-diphosphatricyclo[13.2.1.0^{6,10}]octadecan-17-yl]-1~{H}-purin-6-one, MPXVgp165 | Authors: | Duchoslav, V, Klima, M, Boura, E. | Deposit date: | 2023-04-17 | Release date: | 2023-12-20 | Last modified: | 2024-04-17 | Method: | X-RAY DIFFRACTION (1.65 Å) | Cite: | Fluorinated cGAMP analogs, which act as STING agonists and are not cleavable by poxins: Structural basis of their function. Structure, 32, 2024
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8P44
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![BU of 8p44 by Molmil](/molmil-images/mine/8p44) | Crystal structure of monkeypox virus poxin in complex with the STING agonist MD1202D | Descriptor: | 9-[(1~{S},3~{R},6~{R},8~{R},9~{R},10~{R},12~{R},15~{R},17~{R},18~{R})-8-(6-aminopurin-9-yl)-9,18-bis(fluoranyl)-3,12-bis(oxidanylidene)-3,12-bis(sulfanyl)-2,4,7,11,13-pentaoxa-3$l^{5},12$l^{5}-diphosphatricyclo[13.2.1.0^{6,10}]octadecan-17-yl]-1~{H}-purin-6-one, MPXVgp165 | Authors: | Duchoslav, V, Klima, M, Boura, E. | Deposit date: | 2023-05-19 | Release date: | 2023-12-20 | Last modified: | 2024-04-17 | Method: | X-RAY DIFFRACTION (1.93 Å) | Cite: | Fluorinated cGAMP analogs, which act as STING agonists and are not cleavable by poxins: Structural basis of their function. Structure, 32, 2024
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8ORW
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![BU of 8orw by Molmil](/molmil-images/mine/8orw) | Crystal structure of human STING in complex with the agonist MD1203 | Descriptor: | 9-[(1~{S},6~{R},8~{R},9~{R},10~{R},15~{R},17~{R},18~{R})-8-(6-aminopurin-9-yl)-9,18-bis(fluoranyl)-3,12-bis(oxidanyl)-3,12-bis(oxidanylidene)-2,4,7,11,13-pentaoxa-3$l^{5},12$l^{5}-diphosphatricyclo[13.2.1.0^{6,10}]octadecan-17-yl]-1~{H}-purin-6-one, Stimulator of interferon protein | Authors: | Klima, M, Boura, E. | Deposit date: | 2023-04-17 | Release date: | 2023-12-20 | Last modified: | 2024-04-17 | Method: | X-RAY DIFFRACTION (2.95 Å) | Cite: | Fluorinated cGAMP analogs, which act as STING agonists and are not cleavable by poxins: Structural basis of their function. Structure, 32, 2024
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5LZ3
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![BU of 5lz3 by Molmil](/molmil-images/mine/5lz3) | |
5MRK
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![BU of 5mrk by Molmil](/molmil-images/mine/5mrk) | |
5LZ1
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![BU of 5lz1 by Molmil](/molmil-images/mine/5lz1) | Crystal structure of human ACBD3 GOLD domain | Descriptor: | Golgi resident protein GCP60 | Authors: | Klima, M, Boura, E. | Deposit date: | 2016-09-29 | Release date: | 2016-12-14 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Kobuviral Non-structural 3A Proteins Act as Molecular Harnesses to Hijack the Host ACBD3 Protein. Structure, 25, 2017
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5LVZ
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![BU of 5lvz by Molmil](/molmil-images/mine/5lvz) | Crystal structure of yeast 14-3-3 protein from Lachancea thermotolerans | Descriptor: | KLTH0G14146p | Authors: | Klima, M, Boura, E. | Deposit date: | 2016-09-14 | Release date: | 2016-10-19 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (1.95 Å) | Cite: | Crystal structures of a yeast 14-3-3 protein from Lachancea thermotolerans in the unliganded form and bound to a human lipid kinase PI4KB-derived peptide reveal high evolutionary conservation. Acta Crystallogr.,Sect.F, 72, 2016
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5LZ6
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![BU of 5lz6 by Molmil](/molmil-images/mine/5lz6) | |
7ZIU
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![BU of 7ziu by Molmil](/molmil-images/mine/7ziu) | |
6YZ1
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![BU of 6yz1 by Molmil](/molmil-images/mine/6yz1) | The crystal structure of SARS-CoV-2 nsp10-nsp16 methyltransferase complex with Sinefungin | Descriptor: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, SINEFUNGIN, ZINC ION, ... | Authors: | Krafcikova, P, Silhan, J, Nencka, R, Boura, E. | Deposit date: | 2020-05-06 | Release date: | 2020-05-13 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Structural analysis of the SARS-CoV-2 methyltransferase complex involved in RNA cap creation bound to sinefungin. Nat Commun, 11, 2020
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8B9N
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![BU of 8b9n by Molmil](/molmil-images/mine/8b9n) | |
8A5X
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![BU of 8a5x by Molmil](/molmil-images/mine/8a5x) | |
7ZIT
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![BU of 7zit by Molmil](/molmil-images/mine/7zit) | 14-3-3 in complex with SARS-COV2 N phospho-peptide | Descriptor: | 14-3-3 protein zeta/delta, ACETATE ION, BENZOIC ACID, ... | Authors: | Eisenreichova, A, Boura, E. | Deposit date: | 2022-04-08 | Release date: | 2022-10-26 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (1.79 Å) | Cite: | Structural basis for SARS-CoV-2 nucleocapsid (N) protein recognition by 14-3-3 proteins. J.Struct.Biol., 214, 2022
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8A23
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![BU of 8a23 by Molmil](/molmil-images/mine/8a23) | Crystal structure of SARS-CoV-2 nsp10/nsp16 methyltransferase in complex with TO383 | Descriptor: | (2R,3R,4S,5R)-2-[4-azanyl-5-(2-quinolin-3-ylethynyl)pyrrolo[2,3-d]pyrimidin-7-yl]-5-(hydroxymethyl)oxolane-3,4-diol, 2'-O-methyltransferase nsp16, GLYCEROL, ... | Authors: | Hanigovsky, M, Krafcikova, P, Klima, M, Boura, E. | Deposit date: | 2022-06-02 | Release date: | 2023-06-14 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Crystal structure of SARS-CoV-2 nsp10/nsp16 methyltransferase in
complex with TO383 To Be Published
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7ZKU
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![BU of 7zku by Molmil](/molmil-images/mine/7zku) | Crystal structure of human STING in complex with 3',3'-c-(2'F,2'dAMP-2'dGMP) | Descriptor: | 9-[(1~{S},6~{R},8~{R},9~{R},10~{R},15~{R},17~{R})-8-(6-aminopurin-9-yl)-9-fluoranyl-3,12-bis(oxidanyl)-3,12-bis(oxidanylidene)-2,4,7,11,13-pentaoxa-3$l^{5},12$l^{5}-diphosphatricyclo[13.3.0.0^{6,10}]octadecan-17-yl]-2-azanyl-3~{H}-purin-6-one, Stimulator of interferon protein | Authors: | Klima, M, Smola, M, Boura, E. | Deposit date: | 2022-04-13 | Release date: | 2023-10-25 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | Crystal structure of human STING in complex with 3',3'-c-(2'F,2'dAMP-2'dGMP) To Be Published
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7ZWL
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![BU of 7zwl by Molmil](/molmil-images/mine/7zwl) | Crystal structure of human STING in complex with 3',3'-c-di-(2'F,2'dAMP) | Descriptor: | 9-[(1~{R},6~{R},8~{R},9~{S},10~{R},15~{R},17~{R},18~{S})-17-(6-aminopurin-9-yl)-9,18-bis(fluoranyl)-3,12-bis(oxidanyl)-3,12-bis(oxidanylidene)-2,4,11,13-tetraoxa-3$l^{5},12$l^{5}-diphosphatricyclo[13.3.0.0^{6,10}]octadecan-8-yl]purin-6-amine, Stimulator of interferon protein, Ubiquitin-like protein SMT3 | Authors: | Klima, M, Smola, M, Boura, E. | Deposit date: | 2022-05-19 | Release date: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Crystal structure of human STING in complex with 3',3'-c-di-(2'F,2'dAMP) To Be Published
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7ZV0
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![BU of 7zv0 by Molmil](/molmil-images/mine/7zv0) | Crystal structure of human STING in complex with 3',3'-c-(2'F,2'dAMP-2'F,2'dAMP) | Descriptor: | 9-[(1~{R},6~{R},8~{R},9~{R},10~{R},15~{R},17~{R},18~{S})-8-(6-aminopurin-9-yl)-9,18-bis(fluoranyl)-3,12-bis(oxidanyl)-3,12-bis(oxidanylidene)-2,4,7,11,13-pentaoxa-3$l^{5},12$l^{5}-diphosphatricyclo[13.3.0.0^{6,10}]octadecan-17-yl]purin-6-amine, Stimulator of interferon protein | Authors: | Klima, M, Smola, M, Boura, E. | Deposit date: | 2022-05-13 | Release date: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2.31 Å) | Cite: | Crystal structure of human STING in complex with 3',3'-c-(2'F,2'dAMP-2'F,2'dAMP) To Be Published
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7ZXB
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![BU of 7zxb by Molmil](/molmil-images/mine/7zxb) | Crystal structure of human STING in complex with 3',3'-c-(2'dAMP-2'F,2'dAMP) | Descriptor: | 9-[(1~{R},6~{R},8~{R},10~{S},15~{R},17~{R},18~{S})-8-(6-aminopurin-9-yl)-18-fluoranyl-3,12-bis(oxidanyl)-3,12-bis(oxidanylidene)-2,4,7,11,13-pentaoxa-3$l^{5},12$l^{5}-diphosphatricyclo[13.3.0.0^{6,10}]octadecan-17-yl]purin-6-amine, Stimulator of interferon protein | Authors: | Klima, M, Smola, M, Boura, E. | Deposit date: | 2022-05-20 | Release date: | 2023-11-29 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | Crystal structure of human STING in complex with 3',3'-c-(2'dAMP-2'F,2'dAMP) To Be Published
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7ZVK
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![BU of 7zvk by Molmil](/molmil-images/mine/7zvk) | Crystal structure of human STING in complex with 3',3'-c-(2'F,2'dAMP-IMP) | Descriptor: | 9-[(1~{R},6~{R},8~{R},9~{R},10~{R},15~{R},17~{R},18~{S})-8-(6-aminopurin-9-yl)-9-fluoranyl-3,12,18-tris(oxidanyl)-3,12-bis(oxidanylidene)-2,4,7,11,13-pentaoxa-3$l^{5},12$l^{5}-diphosphatricyclo[13.3.0.0^{6,10}]octadecan-17-yl]-3~{H}-purin-6-one, Stimulator of interferon protein | Authors: | Klima, M, Smola, M, Boura, E. | Deposit date: | 2022-05-16 | Release date: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.83 Å) | Cite: | Crystal structure of human STING in complex with 3',3'-c-(2'F,2'dAMP-IMP) To Be Published
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8A2X
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![BU of 8a2x by Molmil](/molmil-images/mine/8a2x) | Crystal structure of human STING in complex with 3',3'-c-(2'F,2'dAMP(S)-2'F,2'dAMP(S)) | Descriptor: | 9-[(1~{R},3~{R},6~{R},8~{R},9~{R},10~{R},12~{R},15~{R},17~{R},18~{S})-8-(6-aminopurin-9-yl)-9,18-bis(fluoranyl)-3,12-bis(oxidanylidene)-3,12-bis(sulfanyl)-2,4,7,11,13-pentaoxa-3$l^{5},12$l^{5}-diphosphatricyclo[13.3.0.0^{6,10}]octadecan-17-yl]purin-6-amine, Stimulator of interferon protein | Authors: | Klima, M, Smola, M, Boura, E. | Deposit date: | 2022-06-06 | Release date: | 2023-12-20 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | Crystal structure of human STING in complex with 3',3'-c-(2'F,2'dAMP(S)-2'F,2'dAMP(S)) To Be Published
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8B07
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![BU of 8b07 by Molmil](/molmil-images/mine/8b07) | |
8A2H
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![BU of 8a2h by Molmil](/molmil-images/mine/8a2h) | human STING in complex with 2',3'-cyclic-GMP-7-deazaphenyl-AMP | Descriptor: | 2-azanyl-9-[(1~{R},6~{R},8~{R},9~{R},10~{S},15~{R},17~{R},18~{R})-8-(4-azanyl-5-phenyl-pyrrolo[2,3-d]pyrimidin-7-yl)-3,9,12,18-tetrakis(oxidanyl)-3,12-bis(oxidanylidene)-2,4,7,11,13,16-hexaoxa-3$l^{5},12$l^{5}-diphosphatricyclo[13.2.1.0^{6,10}]octadecan-17-yl]-1~{H}-purin-6-one, Stimulator of interferon genes protein | Authors: | Smola, M, Vavrina, Z, Boura, E, Brynda, J. | Deposit date: | 2022-06-03 | Release date: | 2022-10-12 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (2.69 Å) | Cite: | Design, Synthesis, and Biochemical and Biological Evaluation of Novel 7-Deazapurine Cyclic Dinucleotide Analogues as STING Receptor Agonists. J.Med.Chem., 65, 2022
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7ACS
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7ACT
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![BU of 7act by Molmil](/molmil-images/mine/7act) | |