8B07
Crystal structure of monkeypox virus methyltransferase VP39 in complex with sinefungin
Summary for 8B07
Entry DOI | 10.2210/pdb8b07/pdb |
Descriptor | Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase, SINEFUNGIN (3 entities in total) |
Functional Keywords | viral, methyltransferase, vp39, monkeypox, capping, enzyme, viral protein |
Biological source | Monkeypox virus (monkeypox) |
Total number of polymer chains | 2 |
Total formula weight | 72661.76 |
Authors | Silhan, J.,Klima, M.,Boura, E. (deposition date: 2022-09-07, release date: 2023-04-05, Last modification date: 2024-02-07) |
Primary citation | Silhan, J.,Klima, M.,Otava, T.,Skvara, P.,Chalupska, D.,Chalupsky, K.,Kozic, J.,Nencka, R.,Boura, E. Discovery and structural characterization of monkeypox virus methyltransferase VP39 inhibitors reveal similarities to SARS-CoV-2 nsp14 methyltransferase. Nat Commun, 14:2259-2259, 2023 Cited by PubMed: 37080993DOI: 10.1038/s41467-023-38019-1 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.05 Å) |
Structure validation
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