8A23

Crystal structure of SARS-CoV-2 nsp10/nsp16 methyltransferase in complex with TO383

Summary for 8A23

• Entry DOI: 10.2210/pdb8a23/pdb
• Descriptor: 2'-O-methyltransferase nsp16, Non-structural protein 10, (2R,3R,4S,5R)-2-[4-azanyl-5-(2-quinolin-3-ylethynyl)pyrrolo[2,3-d]pyrimidin-7-yl]-5-(hydroxymethyl)oxolane-3,4-diol, ... (5 entities in total)
• Functional Keywords: viral, methyltransferase, inhibitor, viral protein
• Biological source: Severe acute respiratory syndrome coronavirus 2; More
• Total number of polymer chains: 2
• Total formula weight: 47252.85

Authors

Hanigovsky, M.,Krafcikova, P.,Klima, M.,Boura, E. (deposition date: 2022-06-02, release date: 2023-06-14, Last modification date: 2024-02-07)

• Primary citation: Hanigovsky, M.,Krafcikova, P.,Klima, M.,Boura, E.; Crystal structure of SARS-CoV-2 nsp10/nsp16 methyltransferase in complex with TO383; To Be Published,

Experimental method

X-RAY DIFFRACTION (2.8 Å)