8A23
Crystal structure of SARS-CoV-2 nsp10/nsp16 methyltransferase in complex with TO383
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | 2'-O-methyltransferase nsp16 | polymer | 299 | 33486.4 | 1 | UniProt (P0DTD1) Pfam (PF06460) | Severe acute respiratory syndrome coronavirus 2 | Non-structural protein 16,nsp16 |
| 2 | B (B) | Non-structural protein 10 | polymer | 123 | 13126.1 | 1 | UniProt (P0DTD1) Pfam (PF09401) | Severe acute respiratory syndrome coronavirus 2 | nsp10,Growth factor-like peptide,GFL |
| 3 | C (A) | (2R,3R,4S,5R)-2-[4-azanyl-5-(2-quinolin-3-ylethynyl)pyrrolo[2,3-d]pyrimidin-7-yl]-5-(hydroxymethyl)oxolane-3,4-diol | non-polymer | 417.4 | 1 | Chemie (KW6) | |||
| 4 | D (A) | GLYCEROL | non-polymer | 92.1 | 1 | Chemie (GOL) | |||
| 5 | E, F (B) | ZINC ION | non-polymer | 65.4 | 2 | Chemie (ZN) |
Sequence modifications
A: 1 - 298 (UniProt: P0DTD1)
B: 10 - 131 (UniProt: P0DTD1)
| PDB | External Database | Details |
|---|---|---|
| Met 0 | - | initiating methionine |
| PDB | External Database | Details |
|---|---|---|
| Met 9 | - | initiating methionine |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 46612.5 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 640.3 | |
| All* | Total formula weight | 47252.8 |
