7ZKU

Crystal structure of human STING in complex with 3',3'-c-(2'F,2'dAMP-2'dGMP)

Summary for 7ZKU

• Entry DOI: 10.2210/pdb7zku/pdb
• Descriptor: Stimulator of interferon protein, 9-[(1~{S},6~{R},8~{R},9~{R},10~{R},15~{R},17~{R})-8-(6-aminopurin-9-yl)-9-fluoranyl-3,12-bis(oxidanyl)-3,12-bis(oxidanylidene)-2,4,7,11,13-pentaoxa-3$l^{5},12$l^{5}-diphosphatricyclo[13.3.0.0^{6,10}]octadecan-17-yl]-2-azanyl-3~{H}-purin-6-one (3 entities in total)
• Functional Keywords: sting, antiviral, activator, antiviral protein
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 2
• Total formula weight: 47036.56

Authors

Klima, M.,Smola, M.,Boura, E. (deposition date: 2022-04-13, release date: 2023-10-25)

• Primary citation: Klima, M.,Smola, M.,Boura, E.; Crystal structure of human STING in complex with 3',3'-c-(2'F,2'dAMP-2'dGMP); To Be Published,

Experimental method

X-RAY DIFFRACTION (1.7 Å)