8ORV

Crystal structure of monkeypox virus poxin in complex with the STING agonist MD1203

Summary for 8ORV

Entry DOI	10.2210/pdb8orv/pdb
Descriptor	MPXVgp165, 9-[(1~{S},6~{R},8~{R},9~{R},10~{R},15~{R},17~{R},18~{R})-8-(6-aminopurin-9-yl)-9,18-bis(fluoranyl)-3,12-bis(oxidanyl)-3,12-bis(oxidanylidene)-2,4,7,11,13-pentaoxa-3$l^{5},12$l^{5}-diphosphatricyclo[13.2.1.0^{6,10}]octadecan-17-yl]-1~{H}-purin-6-one (3 entities in total)
Functional Keywords	mpox, monkeypox, virus, poxin, viral protein
Biological source	Monkeypox virus
Total number of polymer chains	1
Total formula weight	23171.30
Authors	Duchoslav, V.,Klima, M.,Boura, E. (deposition date: 2023-04-17, release date: 2023-12-20, Last modification date: 2024-04-17)
Primary citation	Klima, M.,Dejmek, M.,Duchoslav, V.,Eisenreichova, A.,Sala, M.,Chalupsky, K.,Chalupska, D.,Novotna, B.,Birkus, G.,Nencka, R.,Boura, E. Fluorinated cGAMP analogs, which act as STING agonists and are not cleavable by poxins: Structural basis of their function. Structure, 32:433-, 2024 Cited by PubMed: 38325369 DOI: 10.1016/j.str.2024.01.008 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.65 Å)

Structure validation