8P45

Crystal structure of human STING in complex with the agonist MD1202D

Summary for 8P45

• Entry DOI: 10.2210/pdb8p45/pdb
• Descriptor: Stimulator of interferon genes protein, 9-[(1~{S},3~{R},6~{R},8~{R},9~{R},10~{R},12~{R},15~{R},17~{R},18~{R})-8-(6-aminopurin-9-yl)-9,18-bis(fluoranyl)-3,12-bis(oxidanylidene)-3,12-bis(sulfanyl)-2,4,7,11,13-pentaoxa-3$l^{5},12$l^{5}-diphosphatricyclo[13.2.1.0^{6,10}]octadecan-17-yl]-1~{H}-purin-6-one (2 entities in total)
• Functional Keywords: sting, antiviral, activator, antiviral protein
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 1
• Total formula weight: 23882.60

Authors

Klima, M.,Boura, E. (deposition date: 2023-05-19, release date: 2023-12-20, Last modification date: 2024-04-17)

• Primary citation: Klima, M.,Dejmek, M.,Duchoslav, V.,Eisenreichova, A.,Sala, M.,Chalupsky, K.,Chalupska, D.,Novotna, B.,Birkus, G.,Nencka, R.,Boura, E.; Fluorinated cGAMP analogs, which act as STING agonists and are not cleavable by poxins: Structural basis of their function.; Structure, 32:433-, 2024; PubMed: 38325369; DOI: 10.1016/j.str.2024.01.008

Experimental method

X-RAY DIFFRACTION (3.23 Å)