1R3V
 
 | | Uroporphyrinogen Decarboxylase single mutant D86E in complex with coproporphyrinogen-I | | Descriptor: | BETA-MERCAPTOETHANOL, COPROPORPHYRINOGEN I, Uroporphyrinogen Decarboxylase | | Authors: | Phillips, J.D, Whitby, F.G, Kushner, J.P, Hill, C.P. | | Deposit date: | 2003-10-03 | | Release date: | 2003-12-09 | | Last modified: | 2023-08-23 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | Structural basis for tetrapyrrole coordination by uroporphyrinogen decarboxylase
Embo J., 22, 2003
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1JR2
 | | Structure of Uroporphyrinogen III Synthase | | Descriptor: | UROPORPHYRINOGEN-III SYNTHASE | | Authors: | Mathews, M.A, Schubert, H.L, Whitby, F.G, Alexander, K.J, Schadick, K, Bergonia, H.A, Phillips, J.D, Hill, C.P. | | Deposit date: | 2001-08-10 | | Release date: | 2001-11-07 | | Last modified: | 2024-02-07 | | Method: | X-RAY DIFFRACTION (1.84 Å) | | Cite: | Crystal structure of human uroporphyrinogen III synthase.
EMBO J., 20, 2001
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3B99
 | | Crystal structure of zebrafish prostacyclin synthase (cytochrome P450 8A1) in complex with substrate analog U51605 | | Descriptor: | (5Z)-7-{(1R,4S,5R,6R)-6-[(1E)-oct-1-en-1-yl]-2,3-diazabicyclo[2.2.1]hept-2-en-5-yl}hept-5-enoic acid, PROTOPORPHYRIN IX CONTAINING FE, Prostaglandin I2 synthase | | Authors: | Li, Y.-C, Chiang, C.-W, Yeh, H.-C, Hsu, P.-Y, Whitby, F.G, Wang, L.-H, Chan, N.-L. | | Deposit date: | 2007-11-03 | | Release date: | 2007-11-20 | | Last modified: | 2023-11-01 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | Structures of Prostacyclin Synthase and Its Complexes with Substrate Analog and Inhibitor Reveal a Ligand-specific Heme Conformation Change
J.Biol.Chem., 283, 2008
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3B98
 | | Crystal structure of zebrafish prostacyclin synthase (cytochrome P450 8A1) | | Descriptor: | PROTOPORPHYRIN IX CONTAINING FE, Prostaglandin I2 synthase | | Authors: | Li, Y.-C, Chiang, C.-W, Yeh, H.-C, Hsu, P.-Y, Whitby, F.G, Wang, L.-H, Chan, N.-L. | | Deposit date: | 2007-11-03 | | Release date: | 2007-11-20 | | Last modified: | 2023-11-01 | | Method: | X-RAY DIFFRACTION (2.08 Å) | | Cite: | Structures of Prostacyclin Synthase and Its Complexes with Substrate Analog and Inhibitor Reveal a Ligand-specific Heme Conformation Change
J.Biol.Chem., 283, 2008
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3C3Q
 | | ALIX Bro1-domain:CHMIP4B co-crystal structure | | Descriptor: | Charged multivesicular body protein 4b peptide, GLYCEROL, Programmed cell death 6-interacting protein | | Authors: | McCullough, J.B, Fisher, R.D, Whitby, F.G, Sundquist, W.I, Hill, C.P. | | Deposit date: | 2008-01-28 | | Release date: | 2008-06-10 | | Last modified: | 2024-02-21 | | Method: | X-RAY DIFFRACTION (2.1 Å) | | Cite: | ALIX-CHMP4 interactions in the human ESCRT pathway.
Proc.Natl.Acad.Sci.Usa, 105, 2008
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3B6H
 | | Crystal structure of human prostacyclin synthase in complex with inhibitor minoxidil | | Descriptor: | 6-PIPERIDIN-1-YLPYRIMIDINE-2,4-DIAMINE 3-OXIDE, PROTOPORPHYRIN IX CONTAINING FE, Prostacyclin synthase, ... | | Authors: | Li, Y.-C, Chiang, C.-W, Yeh, H.-C, Hsu, P.-Y, Whitby, F.G, Wang, L.-H, Chan, N.-L. | | Deposit date: | 2007-10-29 | | Release date: | 2007-11-20 | | Last modified: | 2023-11-01 | | Method: | X-RAY DIFFRACTION (1.62 Å) | | Cite: | Structures of Prostacyclin Synthase and Its Complexes with Substrate Analog and Inhibitor Reveal a Ligand-specific Heme Conformation Change
J.Biol.Chem., 283, 2008
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3C3O
 | | ALIX Bro1-domain:CHMIP4A co-crystal structure | | Descriptor: | Charged multivesicular body protein 4a peptide, GLYCEROL, Programmed cell death 6-interacting protein | | Authors: | McCullough, J.B, Fisher, R.D, Whitby, F.G, Sundquist, W.I, Hill, C.P. | | Deposit date: | 2008-01-28 | | Release date: | 2008-06-10 | | Last modified: | 2023-08-30 | | Method: | X-RAY DIFFRACTION (2.15 Å) | | Cite: | ALIX-CHMP4 interactions in the human ESCRT pathway.
Proc.Natl.Acad.Sci.Usa, 105, 2008
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3C3R
 | | ALIX BRO1 CHMP4C complex | | Descriptor: | Charged multivesicular body protein 4c peptide, GLYCEROL, Programmed cell death 6-interacting protein | | Authors: | McCullough, J.B, Fisher, R.D, Whitby, F.G, Sundquist, W.I, Hill, C.P. | | Deposit date: | 2008-01-28 | | Release date: | 2008-06-10 | | Last modified: | 2024-02-21 | | Method: | X-RAY DIFFRACTION (2.02 Å) | | Cite: | ALIX-CHMP4 interactions in the human ESCRT pathway.
Proc.Natl.Acad.Sci.Usa, 105, 2008
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1YA7
 | | Implications for interactions of proteasome with PAN and PA700 from the 1.9 A structure of a proteasome-11S activator complex | | Descriptor: | GLYCEROL, Proteasome alpha subunit, Proteasome beta subunit, ... | | Authors: | Forster, A, Masters, E.I, Whitby, F.G, Robinson, H, Hill, C.P. | | Deposit date: | 2004-12-17 | | Release date: | 2005-07-26 | | Last modified: | 2023-08-23 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | The 1.9 A structure of a proteasome-11S activator complex and implications for proteasome-PAN/PA700 interactions.
Mol.Cell, 18, 2005
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1Z7Q
 | | Crystal structure of the 20s proteasome from yeast in complex with the proteasome activator PA26 from Trypanosome brucei at 3.2 angstroms resolution | | Descriptor: | Potential proteasome component C5, Proteasome component C1, Proteasome component C11, ... | | Authors: | Forster, A, Whitby, F.G, Hill, C.P. | | Deposit date: | 2005-03-26 | | Release date: | 2005-08-09 | | Last modified: | 2023-08-23 | | Method: | X-RAY DIFFRACTION (3.22 Å) | | Cite: | The 1.9 A structure of a proteasome-11S activator complex and implications for proteasome-PAN/PA700 interactions.
Mol.Cell, 18, 2005
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1YAU
 | | Structure of Archeabacterial 20S proteasome- PA26 complex | | Descriptor: | GLYCEROL, Proteasome alpha subunit, Proteasome beta subunit, ... | | Authors: | Forster, A, Masters, E.I, Whitby, F.G, Robinson, H, Hill, C.P. | | Deposit date: | 2004-12-17 | | Release date: | 2005-07-26 | | Last modified: | 2023-08-23 | | Method: | X-RAY DIFFRACTION (2.4 Å) | | Cite: | The 1.9 A structure of a proteasome-11S activator complex and implications for proteasome-PAN/PA700 interactions.
Mol.Cell, 18, 2005
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1YAR
 | | Structure of Archeabacterial 20S proteasome mutant D9S- PA26 complex | | Descriptor: | GLYCEROL, Proteasome alpha subunit, Proteasome beta subunit, ... | | Authors: | Forster, A, Masters, E.I, Whitby, F.G, Robinson, H, Hill, C.P. | | Deposit date: | 2004-12-17 | | Release date: | 2005-07-26 | | Last modified: | 2023-08-23 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | The 1.9 A structure of a proteasome-11S activator complex and implications for proteasome-PAN/PA700 interactions.
Mol.Cell, 18, 2005
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3EIH
 | | Crystal structure of S.cerevisiae Vps4 in the presence of ATPgammaS | | Descriptor: | 1,2-ETHANEDIOL, MAGNESIUM ION, PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER, ... | | Authors: | Gonciarz, M.D, Whitby, F.G, Eckert, D.M, Kieffer, C, Heroux, A, Sundquist, W.I, Hill, C.P. | | Deposit date: | 2008-09-15 | | Release date: | 2008-09-30 | | Last modified: | 2024-02-21 | | Method: | X-RAY DIFFRACTION (3.25 Å) | | Cite: | Biochemical and structural studies of yeast vps4 oligomerization.
J.Mol.Biol., 384, 2008
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3EIE
 | | Crystal Structure of S.cerevisiae Vps4 in the SO4-bound state | | Descriptor: | SULFATE ION, Vacuolar protein sorting-associated protein 4 | | Authors: | Gonciarz, M.D, Whitby, F.G, Eckert, D.M, Kieffer, C, Heroux, A, Sundquist, W.I, Hill, C.P. | | Deposit date: | 2008-09-15 | | Release date: | 2008-09-30 | | Last modified: | 2024-02-21 | | Method: | X-RAY DIFFRACTION (2.7 Å) | | Cite: | Biochemical and structural studies of yeast vps4 oligomerization.
J.Mol.Biol., 384, 2008
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3GVV
 | | Single-chain UROD Y164G (GY) mutation | | Descriptor: | Uroporphyrinogen decarboxylase | | Authors: | Hill, C.P, Phillips, J.D, Whitby, F.G, Warby, C, Kushner, J.P. | | Deposit date: | 2009-03-31 | | Release date: | 2009-07-07 | | Last modified: | 2024-02-21 | | Method: | X-RAY DIFFRACTION (2.8 Å) | | Cite: | Substrate shuttling between active sites of uroporphyrinogen decarboxylase is not required to generate coproporphyrinogen.
J.Mol.Biol., 389, 2009
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3GW3
 | | human UROD mutant K297N | | Descriptor: | Uroporphyrinogen decarboxylase | | Authors: | Hill, C.P, Phillips, J.D, Whitby, F.G, Warby, C, Kushner, J.P. | | Deposit date: | 2009-03-31 | | Release date: | 2009-07-07 | | Last modified: | 2024-02-21 | | Method: | X-RAY DIFFRACTION (1.7 Å) | | Cite: | Structural and kinetic characterization of mutant human uroporphyrinogen decarboxylases.
Cell Mol Biol (Noisy-le-grand), 55, 2009
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3JRM
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3JSE
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5UXT
 | | Coiled-coil Trimer with Glu:Trp:Lys Triad | | Descriptor: | GLYCEROL, coiled-coil trimer with Glu:Trp:Lys triad | | Authors: | Smith, M.S, Billings, W.M, Whitby, F.G, Miller, M.B, Price, J.L. | | Deposit date: | 2017-02-23 | | Release date: | 2017-08-09 | | Method: | X-RAY DIFFRACTION (2.197 Å) | | Cite: | Enhancing a long-range salt bridge with intermediate aromatic and nonpolar amino acids.
Org. Biomol. Chem., 15, 2017
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3JTL
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3GVR
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3GVW
 | | Single-chain UROD F217Y (YF) mutation | | Descriptor: | Uroporphyrinogen decarboxylase | | Authors: | Hill, C.P, Phillips, J.D, Whitby, F.G, Warby, C, Kushner, J.P. | | Deposit date: | 2009-03-31 | | Release date: | 2009-12-22 | | Last modified: | 2024-02-21 | | Method: | X-RAY DIFFRACTION (2.8 Å) | | Cite: | Substrate shuttling between active sites of uroporphyrinogen decarboxylase is not required to generate coproporphyrinogen.
J.Mol.Biol., 389, 2009
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3GVQ
 | | UROD single-chain dimer | | Descriptor: | Uroporphyrinogen decarboxylase | | Authors: | Hill, C.P, Phillips, J.D, Warby, C, Whitby, F.G, Kushner, J.P. | | Deposit date: | 2009-03-31 | | Release date: | 2009-07-07 | | Last modified: | 2023-09-06 | | Method: | X-RAY DIFFRACTION (2.1 Å) | | Cite: | Substrate shuttling between active sites of uroporphyrinogen decarboxylase is not required to generate coproporphyrinogen.
J.Mol.Biol., 389, 2009
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3GW0
 | | UROD mutant G318R | | Descriptor: | Uroporphyrinogen decarboxylase | | Authors: | Hill, C.P, Phillips, J.D, Whitby, F.G, Warby, C, Kushner, J.P. | | Deposit date: | 2009-03-31 | | Release date: | 2009-07-07 | | Last modified: | 2024-02-21 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Structural and kinetic characterization of mutant human uroporphyrinogen decarboxylases.
Cell Mol Biol (Noisy-le-grand), 55, 2009
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5VKO
 | | SPT6 tSH2-RPB1 1468-1500 pT1471, pS1493 | | Descriptor: | DNA-directed RNA polymerase II subunit RPB1, ISOPROPYL ALCOHOL, Transcription elongation factor SPT6 | | Authors: | Sdano, M.A, Whitby, F.G, Hill, C.P. | | Deposit date: | 2017-04-21 | | Release date: | 2017-09-20 | | Last modified: | 2023-10-04 | | Method: | X-RAY DIFFRACTION (1.8 Å) | | Cite: | A novel SH2 recognition mechanism recruits Spt6 to the doubly phosphorylated RNA polymerase II linker at sites of transcription.
Elife, 6, 2017
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