3B99

Crystal structure of zebrafish prostacyclin synthase (cytochrome P450 8A1) in complex with substrate analog U51605

Summary for 3B99

Entry DOI	10.2210/pdb3b99/pdb
Related	3B6H 3B98
Descriptor	Prostaglandin I2 synthase, PROTOPORPHYRIN IX CONTAINING FE, (5Z)-7-{(1R,4S,5R,6R)-6-[(1E)-oct-1-en-1-yl]-2,3-diazabicyclo[2.2.1]hept-2-en-5-yl}hept-5-enoic acid, ... (4 entities in total)
Functional Keywords	prostacyclin synthase, cytochrome p450 8a1, cyp8a1, substrate analog-enzyme complex, isomerase
Biological source	Danio rerio (zebrafish)
Total number of polymer chains	2
Total formula weight	112925.71
Authors	Li, Y.-C.,Chiang, C.-W.,Yeh, H.-C.,Hsu, P.-Y.,Whitby, F.G.,Wang, L.-H.,Chan, N.-L. (deposition date: 2007-11-03, release date: 2007-11-20, Last modification date: 2023-11-01)
Primary citation	Li, Y.-C.,Chiang, C.-W.,Yeh, H.-C.,Hsu, P.-Y.,Whitby, F.G.,Wang, L.-H.,Chan, N.-L. Structures of Prostacyclin Synthase and Its Complexes with Substrate Analog and Inhibitor Reveal a Ligand-specific Heme Conformation Change J.Biol.Chem., 283:2917-2926, 2008 Cited by PubMed: 18032380 DOI: 10.1074/jbc.M707470200 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.5 Å)

Structure validation