3B6H
Crystal structure of human prostacyclin synthase in complex with inhibitor minoxidil
Summary for 3B6H
Entry DOI | 10.2210/pdb3b6h/pdb |
Related | 2iag 3B98 3B99 |
Descriptor | Prostacyclin synthase, octyl beta-D-glucopyranoside, 6-PIPERIDIN-1-YLPYRIMIDINE-2,4-DIAMINE 3-OXIDE, ... (5 entities in total) |
Functional Keywords | prostacyclin synthase, enzyme-inhibitor complex, cyp8a1, cytochrome p450, endoplasmic reticulum, fatty acid biosynthesis, heme, iron, isomerase, lipid synthesis, membrane, metal-binding, polymorphism, prostaglandin biosynthesis, transmembrane |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 2 |
Total formula weight | 116779.52 |
Authors | Li, Y.-C.,Chiang, C.-W.,Yeh, H.-C.,Hsu, P.-Y.,Whitby, F.G.,Wang, L.-H.,Chan, N.-L. (deposition date: 2007-10-29, release date: 2007-11-20, Last modification date: 2023-11-01) |
Primary citation | Li, Y.-C.,Chiang, C.-W.,Yeh, H.-C.,Hsu, P.-Y.,Whitby, F.G.,Wang, L.-H.,Chan, N.-L. Structures of Prostacyclin Synthase and Its Complexes with Substrate Analog and Inhibitor Reveal a Ligand-specific Heme Conformation Change J.Biol.Chem., 283:2917-2926, 2008 Cited by PubMed: 18032380DOI: 10.1074/jbc.M707470200 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.62 Å) |
Structure validation
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