3B99
Crystal structure of zebrafish prostacyclin synthase (cytochrome P450 8A1) in complex with substrate analog U51605
Summary for 3B99
Entry DOI | 10.2210/pdb3b99/pdb |
Related | 3B6H 3B98 |
Descriptor | Prostaglandin I2 synthase, PROTOPORPHYRIN IX CONTAINING FE, (5Z)-7-{(1R,4S,5R,6R)-6-[(1E)-oct-1-en-1-yl]-2,3-diazabicyclo[2.2.1]hept-2-en-5-yl}hept-5-enoic acid, ... (4 entities in total) |
Functional Keywords | prostacyclin synthase, cytochrome p450 8a1, cyp8a1, substrate analog-enzyme complex, isomerase |
Biological source | Danio rerio (zebrafish) |
Total number of polymer chains | 2 |
Total formula weight | 112925.71 |
Authors | Li, Y.-C.,Chiang, C.-W.,Yeh, H.-C.,Hsu, P.-Y.,Whitby, F.G.,Wang, L.-H.,Chan, N.-L. (deposition date: 2007-11-03, release date: 2007-11-20, Last modification date: 2023-11-01) |
Primary citation | Li, Y.-C.,Chiang, C.-W.,Yeh, H.-C.,Hsu, P.-Y.,Whitby, F.G.,Wang, L.-H.,Chan, N.-L. Structures of Prostacyclin Synthase and Its Complexes with Substrate Analog and Inhibitor Reveal a Ligand-specific Heme Conformation Change J.Biol.Chem., 283:2917-2926, 2008 Cited by PubMed: 18032380DOI: 10.1074/jbc.M707470200 PDB entries with the same primary citation |
Experimental method |
Structure validation
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