3B99
Crystal structure of zebrafish prostacyclin synthase (cytochrome P450 8A1) in complex with substrate analog U51605
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Prostaglandin I2 synthase | polymer | 475 | 54848.9 | 2 | UniProt (A9LLA5) Pfam (PF00067) UniProt (by SIFTS) (F1RE08) | Danio rerio (zebrafish) | cytochrome P450 8A1, Prostacyclin synthase |
| 2 | C, G (A, B) | PROTOPORPHYRIN IX CONTAINING FE | non-polymer | 616.5 | 2 | Chemie (HEM) | |||
| 3 | D, E, F, H, I... (A, B) | (5Z)-7-{(1R,4S,5R,6R)-6-[(1E)-oct-1-en-1-yl]-2,3-diazabicyclo[2.2.1]hept-2-en-5-yl}hept-5-enoic acid | non-polymer | 332.5 | 6 | Chemie (U51) | |||
| 4 | K, L (A, B) | water | water | 18.0 | 223 | Chemie (HOH) |
Sequence modifications
A, B: 17 - 480 (UniProt: A9LLA5)
| PDB | External Database | Details |
|---|---|---|
| Met 10 | - | initiating methionine |
| Ala 11 | - | expression tag |
| Lys 12 | - | expression tag |
| Lys 13 | - | expression tag |
| Thr 14 | - | expression tag |
| Ser 15 | - | expression tag |
| Ser 16 | - | expression tag |
| His 481 | - | expression tag |
| His 482 | - | expression tag |
| His 483 | - | expression tag |
| His 484 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 109697.9 | |
| Non-Polymers* | Number of molecules | 8 |
| Total formula weight | 3227.9 | |
| All* | Total formula weight | 112925.7 |
