3B99
Crystal structure of zebrafish prostacyclin synthase (cytochrome P450 8A1) in complex with substrate analog U51605
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Prostaglandin I2 synthase | polymer | 475 | 54848.9 | 2 | UniProt (A9LLA5) Pfam (PF00067) UniProt (by SIFTS) (F1RE08) | Danio rerio (zebrafish) | cytochrome P450 8A1, Prostacyclin synthase |
| 2 | C, G (A, B) | PROTOPORPHYRIN IX CONTAINING FE | non-polymer | 616.5 | 2 | Chemie (HEM) | |||
| 3 | D, E, F, H, I... (A, B) | (5Z)-7-{(1R,4S,5R,6R)-6-[(1E)-oct-1-en-1-yl]-2,3-diazabicyclo[2.2.1]hept-2-en-5-yl}hept-5-enoic acid | non-polymer | 332.5 | 6 | Chemie (U51) PubChem (20284241) PubChem (177675628) PubChem (44585558) PubChem (53394200) PubChem (57369795) PubChem (9905657) PubChem (94286437) PubChem (94286438) PubChem (15942747) PubChem (98043771) PubChem (98043772) PubChem (137350075) PubChem (137699679) PubChem (168300450) PubChem (171149081) PubChem (171369795) | |||
| 4 | K, L (A, B) | water | water | 18.0 | 223 | Chemie (HOH) |
Sequence modifications
A, B: 17 - 480 (UniProt: A9LLA5)
| PDB | External Database | Details |
|---|---|---|
| Met 10 | - | initiating methionine |
| Ala 11 | - | expression tag |
| Lys 12 | - | expression tag |
| Lys 13 | - | expression tag |
| Thr 14 | - | expression tag |
| Ser 15 | - | expression tag |
| Ser 16 | - | expression tag |
| His 481 | - | expression tag |
| His 482 | - | expression tag |
| His 483 | - | expression tag |
| His 484 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 109697.9 | |
| Non-Polymers* | Number of molecules | 8 |
| Total formula weight | 3227.9 | |
| All* | Total formula weight | 112925.7 |
