3B6H

Crystal structure of human prostacyclin synthase in complex with inhibitor minoxidil

Summary for 3B6H

Entry DOI	10.2210/pdb3b6h/pdb
Related	2iag 3B98 3B99
Descriptor	Prostacyclin synthase, octyl beta-D-glucopyranoside, 6-PIPERIDIN-1-YLPYRIMIDINE-2,4-DIAMINE 3-OXIDE, ... (5 entities in total)
Functional Keywords	prostacyclin synthase, enzyme-inhibitor complex, cyp8a1, cytochrome p450, endoplasmic reticulum, fatty acid biosynthesis, heme, iron, isomerase, lipid synthesis, membrane, metal-binding, polymorphism, prostaglandin biosynthesis, transmembrane
Biological source	Homo sapiens (human)
Total number of polymer chains	2
Total formula weight	116779.52
Authors	Li, Y.-C.,Chiang, C.-W.,Yeh, H.-C.,Hsu, P.-Y.,Whitby, F.G.,Wang, L.-H.,Chan, N.-L. (deposition date: 2007-10-29, release date: 2007-11-20, Last modification date: 2023-11-01)
Primary citation	Li, Y.-C.,Chiang, C.-W.,Yeh, H.-C.,Hsu, P.-Y.,Whitby, F.G.,Wang, L.-H.,Chan, N.-L. Structures of Prostacyclin Synthase and Its Complexes with Substrate Analog and Inhibitor Reveal a Ligand-specific Heme Conformation Change J.Biol.Chem., 283:2917-2926, 2008 Cited by PubMed: 18032380 DOI: 10.1074/jbc.M707470200 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.62 Å)

Structure validation