3GVQ

UROD single-chain dimer

Summary for 3GVQ

Entry DOI	10.2210/pdb3gvq/pdb
Related	1uro 3GVR 3GVV 3GVW
Descriptor	Uroporphyrinogen decarboxylase (2 entities in total)
Functional Keywords	heme, uroporphyrinogen, decarboxylase, alpha-8-beta-8 barrel, lyase, acetylation, cytoplasm, disease mutation, heme biosynthesis, phosphoprotein, porphyrin biosynthesis
Biological source	Homo sapiens (Human)
Cellular location	Cytoplasm: P06132
Total number of polymer chains	1
Total formula weight	40831.77
Authors	Hill, C.P.,Phillips, J.D.,Warby, C.,Whitby, F.G.,Kushner, J.P. (deposition date: 2009-03-31, release date: 2009-07-07, Last modification date: 2023-09-06)
Primary citation	Phillips, J.D.,Warby, C.A.,Whitby, F.G.,Kushner, J.P.,Hill, C.P. Substrate shuttling between active sites of uroporphyrinogen decarboxylase is not required to generate coproporphyrinogen. J.Mol.Biol., 389:306-314, 2009 Cited by PubMed: 19362562 DOI: 10.1016/j.jmb.2009.04.013 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.1 Å)

Structure validation