7ZB5
| Mot1(1-1836):TBP:DNA - post-hydrolysis complex dimer | Descriptor: | DNA (36-MER), Helicase-like protein, Putative tata-box binding protein | Authors: | Woike, S, Eustermann, S, Jung, J, Wenzl, S.J, Hagemann, G, Bartho, J.D, Lammens, K, Butryn, A, Herzog, F, Hopfner, K.-P. | Deposit date: | 2022-03-23 | Release date: | 2023-04-05 | Last modified: | 2023-05-31 | Method: | ELECTRON MICROSCOPY (2.8 Å) | Cite: | Structural basis for TBP displacement from TATA box DNA by the Swi2/Snf2 ATPase Mot1. Nat.Struct.Mol.Biol., 30, 2023
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4YKE
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5DAC
| ATP-gamma-S bound Rad50 from Chaetomium thermophilum in complex with DNA | Descriptor: | 4-(2-AMINOETHYL)BENZENESULFONYL FLUORIDE, DNA (5'-D(P*CP*CP*CP*CP*CP*CP*CP*CP*CP*CP*CP*CP*CP*CP*C)-3'), DNA (5'-D(P*GP*GP*GP*GP*GP*GP*GP*GP*GP*GP*GP*GP*GP*GP*G)-3'), ... | Authors: | Seifert, F.U, Lammens, K, Stoehr, G, Kessler, B, Hopfner, K.-P. | Deposit date: | 2015-08-19 | Release date: | 2016-03-02 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (2.503 Å) | Cite: | Structural mechanism of ATP-dependent DNA binding and DNA end bridging by eukaryotic Rad50. Embo J., 35, 2016
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5DA9
| ATP-gamma-S bound Rad50 from Chaetomium thermophilum in complex with the Rad50-binding domain of Mre11 | Descriptor: | MAGNESIUM ION, PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER, Putative double-strand break protein, ... | Authors: | Seifert, F.U, Lammens, K, Stoehr, G, Kessler, B, Hopfner, K.-P. | Deposit date: | 2015-08-19 | Release date: | 2016-03-02 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | Structural mechanism of ATP-dependent DNA binding and DNA end bridging by eukaryotic Rad50. Embo J., 35, 2016
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7NI6
| Human ATM kinase with bound ATPyS | Descriptor: | MAGNESIUM ION, PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER, Serine-protein kinase ATM, ... | Authors: | Stakyte, K, Rotheneder, M, Lammens, K, Bartho, J.D. | Deposit date: | 2021-02-11 | Release date: | 2021-09-01 | Last modified: | 2021-10-20 | Method: | ELECTRON MICROSCOPY (2.8 Å) | Cite: | Molecular basis of human ATM kinase inhibition. Nat.Struct.Mol.Biol., 28, 2021
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7NI5
| Human ATM kinase with bound inhibitor KU-55933 | Descriptor: | 2-morpholin-4-yl-6-thianthren-1-yl-pyran-4-one, Serine-protein kinase ATM, ZINC ION | Authors: | Bartho, J.D, Stakyte, K, Rotheneder, M, Lammens, K, Hopfner, K.P. | Deposit date: | 2021-02-11 | Release date: | 2021-09-01 | Last modified: | 2021-10-20 | Method: | ELECTRON MICROSCOPY (2.78 Å) | Cite: | Molecular basis of human ATM kinase inhibition. Nat.Struct.Mol.Biol., 28, 2021
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4I1R
| Human MALT1 (caspase-IG3) in complex with thioridazine | Descriptor: | 10-{2-[(2S)-1-methylpiperidin-2-yl]ethyl}-2-(methylsulfanyl)-10H-phenothiazine, Mucosa-associated lymphoid tissue lymphoma translocation protein 1 | Authors: | Schlauderer, F, Lammens, K, Hopfner, K.P. | Deposit date: | 2012-11-21 | Release date: | 2013-08-28 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | Structural Analysis of Phenothiazine Derivatives as Allosteric Inhibitors of the MALT1 Paracaspase. Angew.Chem.Int.Ed.Engl., 52, 2013
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4I1P
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7ZR1
| Chaetomium thermophilum Mre11-Rad50-Nbs1 complex bound to ATPyS (composite structure) | Descriptor: | DH domain-containing protein, Double-strand break repair protein, FHA domain-containing protein, ... | Authors: | Bartho, J.D, Rotheneder, M, Stakyte, K, Lammens, K, Hopfner, K.P. | Deposit date: | 2022-05-03 | Release date: | 2023-01-11 | Last modified: | 2023-12-13 | Method: | ELECTRON MICROSCOPY (4 Å) | Cite: | Cryo-EM structure of the Mre11-Rad50-Nbs1 complex reveals the molecular mechanism of scaffolding functions. Mol.Cell, 83, 2023
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8BAH
| Human Mre11-Nbs1 complex | Descriptor: | Double-strand break repair protein MRE11, MANGANESE (II) ION, Nibrin | Authors: | Bartho, J.D, Rotheneder, M, Stakyte, K, Lammens, K, Hopfner, K.P. | Deposit date: | 2022-10-11 | Release date: | 2023-01-11 | Last modified: | 2023-12-13 | Method: | ELECTRON MICROSCOPY (4.13 Å) | Cite: | Cryo-EM structure of the Mre11-Rad50-Nbs1 complex reveals the molecular mechanism of scaffolding functions. Mol.Cell, 83, 2023
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6GPG
| Structure of the RIG-I Singleton-Merten syndrome variant C268F | Descriptor: | MAGNESIUM ION, Probable ATP-dependent RNA helicase DDX58, RNA (5'-R(*CP*GP*AP*CP*GP*CP*UP*AP*GP*CP*GP*UP*CP*G)-3'), ... | Authors: | Laessig, C, Lammens, K, Hopfner, K.-P. | Deposit date: | 2018-06-05 | Release date: | 2018-08-08 | Last modified: | 2024-05-15 | Method: | X-RAY DIFFRACTION (2.894 Å) | Cite: | Unified mechanisms for self-RNA recognition by RIG-I Singleton-Merten syndrome variants. Elife, 7, 2018
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6GK2
| Helical reconstruction of BCL10 CARD and MALT1 DEATH DOMAIN complex | Descriptor: | B-cell lymphoma/leukemia 10, Mucosa-associated lymphoid tissue lymphoma translocation protein 1 | Authors: | Schlauderer, F, Desfosses, A, Gutsche, I, Hopfner, K.P, Lammens, K. | Deposit date: | 2018-05-18 | Release date: | 2018-10-31 | Method: | ELECTRON MICROSCOPY (4.9 Å) | Cite: | Molecular architecture and regulation of BCL10-MALT1 filaments. Nat Commun, 9, 2018
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6SKY
| FAT and kinase domain of CtTel1 | Descriptor: | MAGNESIUM ION, PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER, Serine/threonine-protein kinase Tel1 | Authors: | Jansma, M, Eustermann, S.E, Kostrewa, D, Lammens, K, Hopfner, K.P. | Deposit date: | 2019-08-16 | Release date: | 2019-10-30 | Last modified: | 2024-05-22 | Method: | ELECTRON MICROSCOPY (2.8 Å) | Cite: | Near-Complete Structure and Model of Tel1ATM from Chaetomium thermophilum Reveals a Robust Autoinhibited ATP State. Structure, 28, 2020
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6SL0
| Complete CtTel1 dimer with C2 symmetry | Descriptor: | MAGNESIUM ION, PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER, Serine/threonine-protein kinase Tel1 | Authors: | Jansma, M, Eustermann, S.E, Kostrewa, D, Lammens, K, Hopfner, K.P. | Deposit date: | 2019-08-16 | Release date: | 2019-10-30 | Last modified: | 2020-01-15 | Method: | ELECTRON MICROSCOPY (3.7 Å) | Cite: | Near-Complete Structure and Model of Tel1ATM from Chaetomium thermophilum Reveals a Robust Autoinhibited ATP State. Structure, 28, 2020
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6SL1
| Structure of the open conformation of CtTel1 | Descriptor: | MAGNESIUM ION, PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER, Serine/threonine-protein kinase Tel1 | Authors: | Jansma, M, Eustermann, S.E, Kostrewa, D, Lammens, K, Hopfner, K.P. | Deposit date: | 2019-08-16 | Release date: | 2019-10-30 | Last modified: | 2020-05-13 | Method: | ELECTRON MICROSCOPY (3.6 Å) | Cite: | Near-Complete Structure and Model of Tel1ATM from Chaetomium thermophilum Reveals a Robust Autoinhibited ATP State. Structure, 28, 2020
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6SKZ
| Structure of the closed conformation of CtTel1 | Descriptor: | MAGNESIUM ION, PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER, Serine/threonine-protein kinase Tel1 | Authors: | Jansma, M, Eustermann, S.E, Kostrewa, D, Lammens, K, Hopfner, K.P. | Deposit date: | 2019-08-16 | Release date: | 2019-10-30 | Last modified: | 2020-01-15 | Method: | ELECTRON MICROSCOPY (3.4 Å) | Cite: | Near-Complete Structure and Model of Tel1ATM from Chaetomium thermophilum Reveals a Robust Autoinhibited ATP State. Structure, 28, 2020
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7A08
| CryoEM Structure of cGAS Nucleosome complex | Descriptor: | Cyclic GMP-AMP synthase, Histone H2A type 1-C, Histone H2B type 1-C/E/F/G/I, ... | Authors: | Michalski, S, de Oliveira Mann, C.C, Witte, G, Bartho, J, Lammens, K, Hopfner, K.P. | Deposit date: | 2020-08-07 | Release date: | 2020-09-23 | Last modified: | 2021-02-10 | Method: | ELECTRON MICROSCOPY (3.11 Å) | Cite: | Structural basis for sequestration and autoinhibition of cGAS by chromatin. Nature, 587, 2020
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2XGP
| Yeast DNA polymerase eta in complex with C8-2-acetylaminofluorene containing DNA | Descriptor: | 5'-D(*CP*8FG*CP*TP*CP*AP*TP*CP*CP*AP*C)-3', 5'-D(*GP*TP*GP*GP*AP*TP*GP*AP*G)-3', CALCIUM ION, ... | Authors: | Scheider, S, Lammens, K, Schorr, S, Hopfner, K.P, Carell, T. | Deposit date: | 2010-06-07 | Release date: | 2010-11-03 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | Mechanism of Replication Blocking and Bypass of Y-Family Polymerase Eta by Bulky Acetylaminofluorene DNA Adducts. Proc.Natl.Acad.Sci.USA, 107, 2010
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3THN
| Crystal structure of Mre11 core with manganese | Descriptor: | Exonuclease, putative, MANGANESE (II) ION, ... | Authors: | Moeckel, C, Lammens, K. | Deposit date: | 2011-08-19 | Release date: | 2011-10-12 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (2.811 Å) | Cite: | ATP driven structural changes of the bacterial Mre11:Rad50 catalytic head complex. Nucleic Acids Res., 40, 2012
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3THO
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7ZKE
| Mot1:TBP:DNA - pre-hydrolysis state | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, BERYLLIUM TRIFLUORIDE ION, DNA (36-MER), ... | Authors: | Woike, S, Eustermann, S, Jung, J, Wenzl, S.J, Hagemann, G, Bartho, J.D, Lammens, K, Butryn, A, Herzog, F, Hopfner, K.-P. | Deposit date: | 2022-04-12 | Release date: | 2023-04-26 | Last modified: | 2023-05-31 | Method: | ELECTRON MICROSCOPY (3.6 Å) | Cite: | Structural basis for TBP displacement from TATA box DNA by the Swi2/Snf2 ATPase Mot1. Nat.Struct.Mol.Biol., 30, 2023
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6RR9
| DNA/RNA binding protein | Descriptor: | GLYCEROL, SULFATE ION, Schlafen family member 5, ... | Authors: | Huber, E, Lammens, K. | Deposit date: | 2019-05-17 | Release date: | 2020-07-08 | Last modified: | 2022-01-26 | Method: | X-RAY DIFFRACTION (3.432 Å) | Cite: | Structural and biochemical characterization of human Schlafen 5. Nucleic Acids Res., 2022
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6S6V
| Resting state of the E. coli Mre11-Rad50 (SbcCD) head complex bound to ATPgS | Descriptor: | MAGNESIUM ION, MANGANESE (II) ION, Nuclease SbcCD subunit C, ... | Authors: | Kaeshammer, L, Saathoff, J.H, Gut, F, Bartho, J, Alt, A, Kessler, B, Lammens, K, Hopfner, K.P. | Deposit date: | 2019-07-03 | Release date: | 2019-09-04 | Last modified: | 2019-11-20 | Method: | ELECTRON MICROSCOPY (3.5 Å) | Cite: | Mechanism of DNA End Sensing and Processing by the Mre11-Rad50 Complex. Mol.Cell, 76, 2019
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4HT1
| Human TWEAK in complex with the Fab fragment of a neutralizing antibody | Descriptor: | Tumor necrosis factor ligand superfamily member 12, chimeric antibody Fab | Authors: | Lammens, A. | Deposit date: | 2012-10-31 | Release date: | 2013-06-12 | Last modified: | 2017-11-15 | Method: | X-RAY DIFFRACTION (2.498 Å) | Cite: | Crystal Structure of Human TWEAK in Complex with the Fab Fragment of a Neutralizing Antibody Reveals Insights into Receptor Binding. Plos One, 8, 2013
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4ON9
| DECH box helicase domain | Descriptor: | CHLORIDE ION, Probable ATP-dependent RNA helicase DDX58, SULFATE ION | Authors: | Deimling, T, Witte, G, Hopfner, K.P. | Deposit date: | 2014-01-28 | Release date: | 2014-07-02 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (2.71 Å) | Cite: | Crystal and solution structure of the human RIG-I SF2 domain Acta Crystallogr.,Sect.F, 70, 2014
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