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Crystal structure of MexR in oxidized state
Descriptor:	Multidrug resistance operon repressor
Authors:	Chen, H, Yi, C, Zhang, J, Zhang, W, Yang, C.-G, He, C.
Deposit date:	2010-04-01
Release date:	2010-07-28
Last modified:	2023-11-01
Method:	X-RAY DIFFRACTION (2.1 Å)
Cite:	Structural insight into the oxidation-sensing mechanism of the antibiotic resistance of regulator MexR Embo Rep., 11, 2010

4J99

Crystal Structure of FGF Receptor 2 (FGFR2) Kinase Domain Harboring the Gain-of-Function K659T Mutation.
Descriptor:	Fibroblast growth factor receptor 2, MAGNESIUM ION, PHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTER, ...
Authors:	Chen, H, Mohammadi, M.
Deposit date:	2013-02-15
Release date:	2013-08-07
Last modified:	2023-09-20
Method:	X-RAY DIFFRACTION (1.8474 Å)
Cite:	Cracking the Molecular Origin of Intrinsic Tyrosine Kinase Activity through Analysis of Pathogenic Gain-of-Function Mutations. Cell Rep, 4, 2013

4J95

Crystal Structure of FGF Receptor 2 (FGFR2) Kinase Domain Harboring the Pathogenic K659N Mutation Responsible for an Unclassified Craniosynostosis Syndrome in Space Group C2.
Descriptor:	Fibroblast growth factor receptor 2, PHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTER, SULFATE ION
Authors:	Chen, H, Mohammadi, M.
Deposit date:	2013-02-15
Release date:	2013-08-07
Last modified:	2023-09-20
Method:	X-RAY DIFFRACTION (2.3767 Å)
Cite:	Cracking the Molecular Origin of Intrinsic Tyrosine Kinase Activity through Analysis of Pathogenic Gain-of-Function Mutations. Cell Rep, 4, 2013

4J96

Crystal Structure of FGF Receptor 2 (FGFR2) Kinase Domain Harboring the Pathogenic Gain-of-Function K659M Mutation Identified in Cervical Cancer.
Descriptor:	CITRATE ANION, Fibroblast growth factor receptor 2, MAGNESIUM ION, ...
Authors:	Chen, H, Mohammadi, M.
Deposit date:	2013-02-15
Release date:	2013-08-07
Last modified:	2023-09-20
Method:	X-RAY DIFFRACTION (2.2972 Å)
Cite:	Cracking the Molecular Origin of Intrinsic Tyrosine Kinase Activity through Analysis of Pathogenic Gain-of-Function Mutations. Cell Rep, 4, 2013

4J97

Crystal Structure of FGF Receptor 2 (FGFR2) Kinase Domain Harboring the Pathogenic Gain-of-Function K659E Mutation Identified in Endometrial Cancer.
Descriptor:	Fibroblast growth factor receptor 2, PHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTER, SULFATE ION
Authors:	Chen, H, Mohammadi, M.
Deposit date:	2013-02-15
Release date:	2013-08-07
Last modified:	2023-09-20
Method:	X-RAY DIFFRACTION (2.5482 Å)
Cite:	Cracking the Molecular Origin of Intrinsic Tyrosine Kinase Activity through Analysis of Pathogenic Gain-of-Function Mutations. Cell Rep, 4, 2013

193D

SOLUTION STRUCTURE OF A QUINOMYCIN BISINTERCALATOR-DNA COMPLEX
Descriptor:	3-HYDROXYQUINALDIC ACID, DNA (5'-D(APCPAPCPGPTPGPT)-3'), QUINOMYCIN
Authors:	Chen, H, Patel, D.J.
Deposit date:	1994-09-30
Release date:	1995-02-27
Last modified:	2017-11-01
Method:	SOLUTION NMR
Cite:	Solution Structure of a Quinomycin Bisintercalator-DNA Complex. J.Mol.Biol., 246, 1995

8G94

Structure of CD69-bound S1PR1 coupled to heterotrimeric Gi
Descriptor:	Early activation antigen CD69, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ...
Authors:	Chen, H, Li, X.
Deposit date:	2023-02-21
Release date:	2023-04-19
Last modified:	2023-04-26
Method:	ELECTRON MICROSCOPY (3.15 Å)
Cite:	Transmembrane protein CD69 acts as an S1PR1 agonist. Elife, 12, 2023

2PWL

Crystal Structure of FGF Receptor 2 (FGFR2) Kinase Domain Harboring the Pathogenic N549H Mutation Responsible for Crouzon Syndrome.
Descriptor:	Fibroblast growth factor receptor 2, PHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTER, SULFATE ION
Authors:	Chen, H, Mohammadi, M.
Deposit date:	2007-05-11
Release date:	2007-09-25
Last modified:	2023-08-30
Method:	X-RAY DIFFRACTION (2.4 Å)
Cite:	A molecular brake in the kinase hinge region regulates the activity of receptor tyrosine kinases. Mol.Cell, 27, 2007

2PVF

Crystal Structure of Tyrosine Phosphorylated Activated FGF Receptor 2 (FGFR2) Kinase Domain in Complex with ATP Analog and Substrate Peptide
Descriptor:	Fibroblast growth factor receptor 2, MAGNESIUM ION, PHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTER
Authors:	Chen, H, Mohammadi, M.
Deposit date:	2007-05-09
Release date:	2007-09-25
Last modified:	2023-11-15
Method:	X-RAY DIFFRACTION (1.8 Å)
Cite:	A molecular brake in the kinase hinge region regulates the activity of receptor tyrosine kinases. Mol.Cell, 27, 2007

2PZ5

Crystal Structure of FGF Receptor 2 (FGFR2) Kinase Domain Harboring the Pathogenic N549T Mutation Responsible for Pfeiffer Syndrome
Descriptor:	Fibroblast growth factor receptor 2, MAGNESIUM ION, PHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTER, ...
Authors:	Chen, H, Mohammadi, M.
Deposit date:	2007-05-17
Release date:	2007-09-25
Last modified:	2023-08-30
Method:	X-RAY DIFFRACTION (2.4 Å)
Cite:	A molecular brake in the kinase hinge region regulates the activity of receptor tyrosine kinases. Mol.Cell, 27, 2007

2PSQ

Crystal Structure of Unphosphorylated Unactivated Wild Type FGF Receptor 2 (FGFR2) Kinase Domain
Descriptor:	Fibroblast growth factor receptor 2, SULFATE ION
Authors:	Chen, H, Mohammadi, M.
Deposit date:	2007-05-07
Release date:	2007-09-25
Last modified:	2023-08-30
Method:	X-RAY DIFFRACTION (2.4 Å)
Cite:	A molecular brake in the kinase hinge region regulates the activity of receptor tyrosine kinases. Mol.Cell, 27, 2007

2PVY

Crystal Structure of FGF Receptor 2 (FGFR2) Kinase Domain Harboring the Pathogenic K659N Mutation Responsible for an Unclassified Craniosynostosis Syndrome.
Descriptor:	Fibroblast growth factor receptor 2, PHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTER, SULFATE ION
Authors:	Chen, H, Mohammadi, M.
Deposit date:	2007-05-10
Release date:	2007-09-25
Last modified:	2023-08-30
Method:	X-RAY DIFFRACTION (2.2 Å)
Cite:	A molecular brake in the kinase hinge region regulates the activity of receptor tyrosine kinases. Mol.Cell, 27, 2007

2PZR

Crystal Structure of FGF Receptor 2 (FGFR2) Kinase Domain Harboring the Pathogenic K641R Mutation Responsible for Pfeiffer Syndrome
Descriptor:	Fibroblast growth factor receptor 2, PHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTER, SULFATE ION
Authors:	Chen, H, Mohammadi, M.
Deposit date:	2007-05-18
Release date:	2007-09-25
Last modified:	2023-08-30
Method:	X-RAY DIFFRACTION (3 Å)
Cite:	A molecular brake in the kinase hinge region regulates the activity of receptor tyrosine kinases. Mol.Cell, 27, 2007

2PY3

Crystal Structure of FGF Receptor 2 (FGFR2) Kinase Domain Harboring the Pathogenic E565G Mutation Responsible for Pfeiffer Syndrome
Descriptor:	Fibroblast growth factor receptor 2, MAGNESIUM ION, PHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTER, ...
Authors:	Chen, H, Mohammadi, M.
Deposit date:	2007-05-15
Release date:	2007-09-25
Last modified:	2023-08-30
Method:	X-RAY DIFFRACTION (2.3 Å)
Cite:	A molecular brake in the kinase hinge region regulates the activity of receptor tyrosine kinases. Mol.Cell, 27, 2007

2PZP

Crystal Structure of FGF Receptor 2 (FGFR2) Kinase Domain Harboring the Pathogenic K526E Mutation Responsible for Crouzon Syndrome
Descriptor:	Fibroblast growth factor receptor 2, MAGNESIUM ION, PHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTER, ...
Authors:	Chen, H, Mohammadi, M.
Deposit date:	2007-05-18
Release date:	2007-09-25
Last modified:	2023-08-30
Method:	X-RAY DIFFRACTION (2.4 Å)
Cite:	A molecular brake in the kinase hinge region regulates the activity of receptor tyrosine kinases. Mol.Cell, 27, 2007

2Q0B

Crystal Structure of FGF Receptor 2 (FGFR2) Kinase Domain Harboring the Pathogenic E565A Mutation Responsible for Pfeiffer Syndrome
Descriptor:	Fibroblast growth factor receptor 2, PHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTER, SULFATE ION
Authors:	Chen, H, Mohammadi, M.
Deposit date:	2007-05-21
Release date:	2007-09-25
Last modified:	2023-08-30
Method:	X-RAY DIFFRACTION (2.9 Å)
Cite:	A molecular brake in the kinase hinge region regulates the activity of receptor tyrosine kinases. Mol.Cell, 27, 2007

5IWD

HCMV DNA polymerase subunit UL44 complex with a small molecule
Descriptor:	5-methylidene-3-(methylsulfanyl)-2-benzothiophen-4(5H)-one, DNA polymerase processivity factor
Authors:	Chen, H, Coen, D.M, Hogle, J.M, Filman, D.J.
Deposit date:	2016-03-22
Release date:	2016-11-30
Last modified:	2019-12-11
Method:	X-RAY DIFFRACTION (2.56 Å)
Cite:	A Small Covalent Allosteric Inhibitor of Human Cytomegalovirus DNA Polymerase Subunit Interactions. ACS Infect Dis, 3, 2017

5IXA

HCMV DNA polymerase processivity subunit UL44 at neutral pH and low salt
Descriptor:	DNA polymerase processivity factor
Authors:	Chen, H, Coen, D.M, Hogle, J.M, Filman, D.J.
Deposit date:	2016-03-23
Release date:	2016-11-30
Last modified:	2023-09-27
Method:	X-RAY DIFFRACTION (2.684 Å)
Cite:	A Small Covalent Allosteric Inhibitor of Human Cytomegalovirus DNA Polymerase Subunit Interactions. ACS Infect Dis, 3, 2017

7D8P

CRTC1 pSer151 peptide in complex with 14-3-3 zeta
Descriptor:	14-3-3 protein zeta/delta, CRTC1 pSer151 peptide, GLYCEROL
Authors:	Chen, H, Zhang, H, Xiang, S.
Deposit date:	2020-10-08
Release date:	2021-02-24
Last modified:	2023-11-29
Method:	X-RAY DIFFRACTION (2 Å)
Cite:	Structural Insights into the Interaction Between CRTCs and 14-3-3. J.Mol.Biol., 433, 2021

7D9V

CRTC1 pSer245 peptide in complex with 14-3-3 zeta
Descriptor:	14-3-3 protein zeta/delta, CRTC1 pSer245 peptide, GLYCEROL
Authors:	Chen, H, Zhang, H, Xiang, S.
Deposit date:	2020-10-14
Release date:	2021-02-24
Last modified:	2023-11-29
Method:	X-RAY DIFFRACTION (2.21 Å)
Cite:	Structural Insights into the Interaction Between CRTCs and 14-3-3. J.Mol.Biol., 433, 2021

7D8H

CRTC1 pSer64 peptide in complex with 14-3-3 zeta
Descriptor:	14-3-3 protein zeta/delta, CRTC1 pSer64 peptide
Authors:	Chen, H, Zhang, H, Xiang, S.
Deposit date:	2020-10-08
Release date:	2021-02-24
Last modified:	2023-11-29
Method:	X-RAY DIFFRACTION (2.42 Å)
Cite:	Structural Insights into the Interaction Between CRTCs and 14-3-3. J.Mol.Biol., 433, 2021

5Y59

Crystal structure of Ku80 and Sir4
Descriptor:	ATP-dependent DNA helicase II subunit 2, SULFATE ION, Sir4p
Authors:	Chen, H, Xue, J, Wu, J, Lei, M.
Deposit date:	2017-08-08
Release date:	2017-12-20
Last modified:	2024-03-27
Method:	X-RAY DIFFRACTION (2.402 Å)
Cite:	Structural Insights into Yeast Telomerase Recruitment to Telomeres Cell, 172, 2018

5Y5A

Crystal structure of Est1 and Cdc13
Descriptor:	KLLA0F20702p, KLLA0F20922p
Authors:	Chen, H, Xue, J, Wu, J, Lei, M.
Deposit date:	2017-08-08
Release date:	2017-12-20
Last modified:	2024-03-27
Method:	X-RAY DIFFRACTION (2.206 Å)
Cite:	Structural Insights into Yeast Telomerase Recruitment to Telomeres Cell, 172, 2018

5Y58

Crystal structure of Ku70/80 and TLC1
Descriptor:	ATP-dependent DNA helicase II subunit 1, ATP-dependent DNA helicase II subunit 2, TLC1
Authors:	Chen, H, Xue, J, Wu, J, Lei, M.
Deposit date:	2017-08-08
Release date:	2017-12-20
Last modified:	2024-03-27
Method:	X-RAY DIFFRACTION (2.8 Å)
Cite:	Structural Insights into Yeast Telomerase Recruitment to Telomeres Cell, 172, 2018

7D7W

Crystal Structure of the Domain1 of NAD+ Riboswitch with nicotinamide adenine dinucleotide (NAD+)
Descriptor:	18GAAA (52-MER), GUANOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ...
Authors:	Chen, H, Ren, A.M.
Deposit date:	2020-10-06
Release date:	2020-11-25
Last modified:	2023-11-29
Method:	X-RAY DIFFRACTION (2.391 Å)
Cite:	Structural distinctions between NAD+ riboswitch domains 1 and 2 determine differential folding and ligand binding. Nucleic Acids Res., 48, 2020

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