5TUR
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![BU of 5tur by Molmil](/molmil-images/mine/5tur) | Pim-1 kinase in complex with a 7-azaindole | Descriptor: | 1-methyl-2-[4-(piperazin-1-yl)phenyl]-1H-pyrrolo[2,3-b]pyridine-4-carbonitrile, Serine/threonine-protein kinase pim-1 | Authors: | Mechin, I, Zhang, Y, Wang, R, Batchelor, J.D, Mclean, L. | Deposit date: | 2016-11-07 | Release date: | 2017-10-11 | Last modified: | 2024-03-06 | Method: | X-RAY DIFFRACTION (2.948 Å) | Cite: | Discovery of N-substituted 7-azaindoles as PIM1 kinase inhibitors - Part I. Bioorg. Med. Chem. Lett., 27, 2017
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5TOE
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![BU of 5toe by Molmil](/molmil-images/mine/5toe) | Pim-1 kinase in complex with a 7-azaindole | Descriptor: | 2-[4-(piperazin-1-yl)phenyl]-1H-pyrrolo[2,3-b]pyridine-4-carbonitrile, Serine/threonine-protein kinase pim-1 | Authors: | Mclean, L, Mechin, I, Zhang, Y, Wang, R, Batchelor, J.D. | Deposit date: | 2016-10-17 | Release date: | 2017-10-11 | Last modified: | 2024-03-06 | Method: | X-RAY DIFFRACTION (2.301 Å) | Cite: | Discovery of N-substituted 7-azaindoles as PIM1 kinase inhibitors - Part I. Bioorg. Med. Chem. Lett., 27, 2017
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5Y36
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![BU of 5y36 by Molmil](/molmil-images/mine/5y36) | Cryo-EM structure of SpCas9-sgRNA-DNA ternary complex | Descriptor: | CRISPR-associated endonuclease Cas9/Csn1, MAGNESIUM ION, complementary DNA strand, ... | Authors: | Huang, Q, Li, G, Huai, C. | Deposit date: | 2017-07-27 | Release date: | 2017-12-06 | Last modified: | 2024-03-27 | Method: | ELECTRON MICROSCOPY (5.2 Å) | Cite: | Structural insights into DNA cleavage activation of CRISPR-Cas9 system Nat Commun, 8, 2017
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7E0Z
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![BU of 7e0z by Molmil](/molmil-images/mine/7e0z) | Crystal structure of PKAc-PLN complex | Descriptor: | MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, PLN, ... | Authors: | Qin, J, Yuchi, Z. | Deposit date: | 2021-01-28 | Release date: | 2022-04-27 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.162 Å) | Cite: | Structures of PKA-phospholamban complexes reveal a mechanism of familial dilated cardiomyopathy. Elife, 11, 2022
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7E12
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![BU of 7e12 by Molmil](/molmil-images/mine/7e12) | Crystal structure of PKAc-A11E complex | Descriptor: | MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, THR-ARG-SER-GLU-ILE-ARG-ARG-ALA-SER-THR-ILE-GLU, ... | Authors: | Qin, J, Lin, L, Yuchi, Z. | Deposit date: | 2021-01-28 | Release date: | 2022-04-27 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.796 Å) | Cite: | Structures of PKA-phospholamban complexes reveal a mechanism of familial dilated cardiomyopathy. Elife, 11, 2022
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7E11
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![BU of 7e11 by Molmil](/molmil-images/mine/7e11) | Crystal structure of PKAc-PLN R9C complex | Descriptor: | MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, PLN, ... | Authors: | Qin, J, Lin, L, Yuchi, Z. | Deposit date: | 2021-01-28 | Release date: | 2022-04-27 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (3.43 Å) | Cite: | Structures of PKA-phospholamban complexes reveal a mechanism of familial dilated cardiomyopathy. Elife, 11, 2022
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5Y87
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![BU of 5y87 by Molmil](/molmil-images/mine/5y87) | |
5KCX
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![BU of 5kcx by Molmil](/molmil-images/mine/5kcx) | Pim-1 kinase in Complex with a Selective N-substituted 7-azaindole Inhibitor | Descriptor: | 4-chloranyl-1-methyl-2-[4-(4-methylpiperazin-1-yl)phenyl]pyrrolo[2,3-b]pyridine-6-carboxamide, ACETATE ION, IMIDAZOLE, ... | Authors: | Mechin, I, McLean, L.R, Zhang, Y, Wang, R. | Deposit date: | 2016-06-07 | Release date: | 2017-07-19 | Last modified: | 2024-03-06 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Discovery of N-substituted 7-azaindoles as PIM1 kinase inhibitors - Part I. Bioorg. Med. Chem. Lett., 27, 2017
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7XIC
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![BU of 7xic by Molmil](/molmil-images/mine/7xic) | S-ECD (Omicron) in complex with STS165 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein, ... | Authors: | Li, Y.N, Shen, Y.P, Zhang, Y.Y, Yan, R.H. | Deposit date: | 2022-04-12 | Release date: | 2022-06-15 | Last modified: | 2022-06-22 | Method: | ELECTRON MICROSCOPY (3.3 Å) | Cite: | Structural and functional analysis of an inter-Spike bivalent neutralizing antibody against SARS-CoV-2 variants. Iscience, 25, 2022
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7XID
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![BU of 7xid by Molmil](/molmil-images/mine/7xid) | S-ECD (Omicron) in complex with PD of ACE2 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Angiotensin-converting enzyme 2, ... | Authors: | Li, Y.N, Shen, Y.P, Zhang, Y.Y, Yan, R.H. | Deposit date: | 2022-04-12 | Release date: | 2022-06-15 | Last modified: | 2022-06-22 | Method: | ELECTRON MICROSCOPY (3.3 Å) | Cite: | Structural and functional analysis of an inter-Spike bivalent neutralizing antibody against SARS-CoV-2 variants. Iscience, 25, 2022
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1YGE
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![BU of 1yge by Molmil](/molmil-images/mine/1yge) | LIPOXYGENASE-1 (SOYBEAN) AT 100K | Descriptor: | FE (III) ION, LIPOXYGENASE-1 | Authors: | Minor, W, Steczko, J, Stec, B, Otwinowski, Z, Bolin, J.T, Walter, R, Axelrod, B. | Deposit date: | 1996-06-04 | Release date: | 1997-07-23 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (1.4 Å) | Cite: | Crystal structure of soybean lipoxygenase L-1 at 1.4 A resolution. Biochemistry, 35, 1996
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5Y85
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![BU of 5y85 by Molmil](/molmil-images/mine/5y85) | |
3HMH
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![BU of 3hmh by Molmil](/molmil-images/mine/3hmh) | Crystal structure of the second bromodomain of human TBP-associated factor RNA polymerase 1-like (TAF1L) | Descriptor: | Transcription initiation factor TFIID 210 kDa subunit | Authors: | Filippakopoulos, P, Picaud, S, Keates, T, Zhang, Y, Pike, A.C.W, von Delft, F, Arrowsmith, C.H, Edwards, A, Weigelt, J, Bountra, C, Knapp, S, Structural Genomics Consortium (SGC) | Deposit date: | 2009-05-29 | Release date: | 2009-06-23 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (2.05 Å) | Cite: | Histone recognition and large-scale structural analysis of the human bromodomain family. Cell(Cambridge,Mass.), 149, 2012
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5ZBS
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![BU of 5zbs by Molmil](/molmil-images/mine/5zbs) | Crystal Structure of Kinesin-3 KIF13B motor Y73C mutant | Descriptor: | Kinesin family member 13B, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER | Authors: | Ren, J.Q, Wang, S, Feng, W. | Deposit date: | 2018-02-12 | Release date: | 2018-05-30 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2.203 Å) | Cite: | Structural Delineation of the Neck Linker of Kinesin-3 for Processive Movement. J. Mol. Biol., 430, 2018
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5YZ2
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![BU of 5yz2 by Molmil](/molmil-images/mine/5yz2) | the cystathionine-beta-synthase (CBS) domain of magnesium and cobalt efflux protein CorC in complex with both C2'- and C3'-endo AMP | Descriptor: | ADENOSINE MONOPHOSPHATE, Magnesium and cobalt efflux protein CorC | Authors: | Feng, N, Qi, C, Li, D.F, Wang, D.C. | Deposit date: | 2017-12-12 | Release date: | 2018-05-30 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (1.75 Å) | Cite: | The C2'- and C3'-endo equilibrium for AMP molecules bound in the cystathionine-beta-synthase domain. Biochem. Biophys. Res. Commun., 497, 2018
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5ZBR
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![BU of 5zbr by Molmil](/molmil-images/mine/5zbr) | Crystal Structure of Kinesin-3 KIF13B motor domain in AMPPNP form | Descriptor: | Kinesin family member 13B, MAGNESIUM ION, PHOSPHATE ION, ... | Authors: | Ren, J.Q, Wang, S, Feng, W. | Deposit date: | 2018-02-12 | Release date: | 2018-05-30 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Structural Delineation of the Neck Linker of Kinesin-3 for Processive Movement. J. Mol. Biol., 430, 2018
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3HZU
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![BU of 3hzu by Molmil](/molmil-images/mine/3hzu) | |
7V8E
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![BU of 7v8e by Molmil](/molmil-images/mine/7v8e) | Crystal structure of IpaH1.4 LRR domain bound to HOIL-1L UBL domain. | Descriptor: | RING-type E3 ubiquitin transferase, RanBP-type and C3HC4-type zinc finger-containing protein 1 | Authors: | Liu, J, Wang, Y, Pan, L. | Deposit date: | 2021-08-22 | Release date: | 2022-03-30 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Mechanistic insights into the subversion of the linear ubiquitin chain assembly complex by the E3 ligase IpaH1.4 of Shigella flexneri. Proc.Natl.Acad.Sci.USA, 119, 2022
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7V8G
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![BU of 7v8g by Molmil](/molmil-images/mine/7v8g) | Crystal structure of HOIP RING1 domain bound to IpaH1.4 LRR domain | Descriptor: | E3 ubiquitin-protein ligase RNF31, RING-type E3 ubiquitin transferase, ZINC ION | Authors: | Liu, J, Wang, Y, Pan, L. | Deposit date: | 2021-08-23 | Release date: | 2022-03-30 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.75 Å) | Cite: | Mechanistic insights into the subversion of the linear ubiquitin chain assembly complex by the E3 ligase IpaH1.4 of Shigella flexneri. Proc.Natl.Acad.Sci.USA, 119, 2022
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7V8F
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![BU of 7v8f by Molmil](/molmil-images/mine/7v8f) | Crystal structure of UBE2L3 bound to HOIP RING1 domain. | Descriptor: | E3 ubiquitin-protein ligase RNF31, Ubiquitin-conjugating enzyme E2 L3, ZINC ION | Authors: | Liu, J, Wang, Y, Pan, L. | Deposit date: | 2021-08-22 | Release date: | 2022-03-30 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (1.66 Å) | Cite: | Mechanistic insights into the subversion of the linear ubiquitin chain assembly complex by the E3 ligase IpaH1.4 of Shigella flexneri. Proc.Natl.Acad.Sci.USA, 119, 2022
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7V8H
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![BU of 7v8h by Molmil](/molmil-images/mine/7v8h) | Crystal structure of LRR domain from Shigella flexneri IpaH1.4 | Descriptor: | RING-type E3 ubiquitin transferase | Authors: | Liu, J, Wang, Y, Pan, L. | Deposit date: | 2021-08-23 | Release date: | 2022-03-30 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.46 Å) | Cite: | Mechanistic insights into the subversion of the linear ubiquitin chain assembly complex by the E3 ligase IpaH1.4 of Shigella flexneri. Proc.Natl.Acad.Sci.USA, 119, 2022
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5Z55
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![BU of 5z55 by Molmil](/molmil-images/mine/5z55) | |
7XSP
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![BU of 7xsp by Molmil](/molmil-images/mine/7xsp) | Structure of gRAMP-target RNA | Descriptor: | RAMP superfamily protein, RNA (35-MER), RNA (5'-R(P*GP*GP*GP*GP*CP*AP*GP*AP*AP*AP*AP*UP*UP*GP*G)-3'), ... | Authors: | Feng, Y, Zhang, L.X. | Deposit date: | 2022-05-15 | Release date: | 2022-11-09 | Last modified: | 2024-07-03 | Method: | ELECTRON MICROSCOPY (2.89 Å) | Cite: | Target RNA activates the protease activity of Craspase to confer antiviral defense. Mol.Cell, 82, 2022
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7YHS
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![BU of 7yhs by Molmil](/molmil-images/mine/7yhs) | Structure of Csy-AcrIF4-dsDNA | Descriptor: | AcrIF4, CRISPR type I-F/YPEST-associated protein Csy2, CRISPR-associated protein Csy3, ... | Authors: | Feng, Y, Zhang, L.X. | Deposit date: | 2022-07-14 | Release date: | 2023-03-29 | Last modified: | 2024-07-03 | Method: | ELECTRON MICROSCOPY (3.37 Å) | Cite: | Anti-CRISPR protein AcrIF4 inhibits the type I-F CRISPR-Cas surveillance complex by blocking nuclease recruitment and DNA cleavage. J.Biol.Chem., 298, 2022
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7Y4F
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![BU of 7y4f by Molmil](/molmil-images/mine/7y4f) | bacterial DPP4 | Descriptor: | Dipeptidyl peptidase IV | Authors: | Hang, J, Jiang, C, Wang, K, Zhang, Z, Guo, F, Liu, J, Wang, G, Lei, X, Gonzalez, F, Qiao, J. | Deposit date: | 2022-06-14 | Release date: | 2023-06-14 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (1.918 Å) | Cite: | Microbial-host-isozyme analyses reveal microbial DPP4 as a potential antidiabetic target. Science, 381, 2023
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