7SR8
 
 | | Molecular mechanism of the the wake-promoting agent TAK-925 | | Descriptor: | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Hypocretin receptor type 2, ... | | Authors: | Yin, J, Chapman, K, Lian, P, De Brabander, J.K, Rosenbaum, D.M. | | Deposit date: | 2021-11-08 | | Release date: | 2022-06-08 | | Method: | ELECTRON MICROSCOPY (3.3 Å) | | Cite: | Molecular mechanism of the wake-promoting agent TAK-925.
Nat Commun, 13, 2022
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8EIT
 | | Structure of FFAR1-Gq complex bound to DHA | | Descriptor: | A modified Guanine nucleotide-binding protein G(q) subunit alpha, DOCOSA-4,7,10,13,16,19-HEXAENOIC ACID, Free fatty acid receptor 1, ... | | Authors: | Kumari, P, Inoue, A, Chapman, K, Lian, P, Rosenbaum, D.M. | | Deposit date: | 2022-09-15 | | Release date: | 2023-05-24 | | Last modified: | 2023-05-31 | | Method: | ELECTRON MICROSCOPY (2.8 Å) | | Cite: | Molecular mechanism of fatty acid activation of FFAR1.
Proc.Natl.Acad.Sci.USA, 120, 2023
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8EJK
 | | Structure of FFAR1-Gq complex bound to TAK-875 in a lipid nanodisc | | Descriptor: | A modified Guanine nucleotide-binding protein G(q) subunit alpha, Free fatty acid receptor 1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | | Authors: | Kumari, P, Inoue, A, Chapman, K, Lian, P, Rosenbaum, D.M. | | Deposit date: | 2022-09-17 | | Release date: | 2023-05-24 | | Last modified: | 2023-05-31 | | Method: | ELECTRON MICROSCOPY (3.4 Å) | | Cite: | Molecular mechanism of fatty acid activation of FFAR1.
Proc.Natl.Acad.Sci.USA, 120, 2023
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8EJC
 | | Structure of FFAR1-Gq complex bound to TAK-875 | | Descriptor: | A modified Guanine nucleotide-binding protein G(q) subunit alpha, Free fatty acid receptor 1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | | Authors: | Kumari, P, Inoue, A, Chapman, K, Lian, P, Rosenbaum, D.M. | | Deposit date: | 2022-09-16 | | Release date: | 2023-05-24 | | Last modified: | 2023-05-31 | | Method: | ELECTRON MICROSCOPY (3 Å) | | Cite: | Molecular mechanism of fatty acid activation of FFAR1.
Proc.Natl.Acad.Sci.USA, 120, 2023
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1ANK
 | | THE CLOSED CONFORMATION OF A HIGHLY FLEXIBLE PROTEIN: THE STRUCTURE OF E. COLI ADENYLATE KINASE WITH BOUND AMP AND AMPPNP | | Descriptor: | ADENOSINE MONOPHOSPHATE, ADENYLATE KINASE, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER | | Authors: | Berry, M.B, Meador, B, Bilderback, T, Liang, P, Glaser, M, Phillips Jr, G.N. | | Deposit date: | 1994-02-28 | | Release date: | 1994-05-31 | | Last modified: | 2024-02-07 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | The closed conformation of a highly flexible protein: the structure of E. coli adenylate kinase with bound AMP and AMPPNP.
Proteins, 19, 1994
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1J4N
 | | Crystal Structure of the AQP1 water channel | | Descriptor: | AQUAPORIN 1, nonyl beta-D-glucopyranoside | | Authors: | Sui, H, Han, B.-G, Lee, J.K, Walian, P, Jap, B.K. | | Deposit date: | 2001-10-19 | | Release date: | 2002-03-27 | | Last modified: | 2023-12-27 | | Method: | X-RAY DIFFRACTION (2.2 Å) | | Cite: | Structural basis of water-specific transport through the AQP1 water channel.
Nature, 414, 2001
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1JV6
 | | BACTERIORHODOPSIN D85S/F219L DOUBLE MUTANT AT 2.00 ANGSTROM RESOLUTION | | Descriptor: | 1-[2,6,10.14-TETRAMETHYL-HEXADECAN-16-YL]-2-[2,10,14-TRIMETHYLHEXADECAN-16-YL]GLYCEROL, Bacteriorhodopsin, RETINAL | | Authors: | Rouhani, S, Cartailler, J.-P, Facciotti, M.T, Walian, P, Needleman, R, Lanyi, J.K, Glaeser, R.M, Luecke, H. | | Deposit date: | 2001-08-28 | | Release date: | 2001-10-31 | | Last modified: | 2023-08-16 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Crystal structure of the D85S mutant of bacteriorhodopsin: model of an O-like photocycle intermediate.
J.Mol.Biol., 313, 2001
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1JV7
 | | BACTERIORHODOPSIN O-LIKE INTERMEDIATE STATE OF THE D85S MUTANT AT 2.25 ANGSTROM RESOLUTION | | Descriptor: | 1-[2,6,10.14-TETRAMETHYL-HEXADECAN-16-YL]-2-[2,10,14-TRIMETHYLHEXADECAN-16-YL]GLYCEROL, Bacteriorhodopsin, RETINAL | | Authors: | Rouhani, S, Cartailler, J.-P, Facciotti, M.T, Walian, P, Needleman, R, Lanyi, J.K, Glaeser, R.M, Luecke, H. | | Deposit date: | 2001-08-28 | | Release date: | 2001-10-31 | | Last modified: | 2023-08-16 | | Method: | X-RAY DIFFRACTION (2.25 Å) | | Cite: | Crystal structure of the D85S mutant of bacteriorhodopsin: model of an O-like photocycle intermediate.
J.Mol.Biol., 313, 2001
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3DD4
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7SQO
 | | Structure of the orexin-2 receptor(OX2R) bound to TAK-925, Gi and scFv16 | | Descriptor: | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(i) subunit alpha-1, ... | | Authors: | McGrath, A.P, Kang, Y, Flinspach, M. | | Deposit date: | 2021-11-05 | | Release date: | 2022-05-25 | | Last modified: | 2022-07-06 | | Method: | ELECTRON MICROSCOPY (3.17 Å) | | Cite: | Molecular mechanism of the wake-promoting agent TAK-925.
Nat Commun, 13, 2022
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8XZF
 | | Cryo-EM structure of the WN561-bound human APLNR-Gi complex | | Descriptor: | Apelin receptor, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | | Authors: | Wang, W, Ji, S, Zhang, Y. | | Deposit date: | 2024-01-21 | | Release date: | 2024-03-20 | | Last modified: | 2024-03-27 | | Method: | ELECTRON MICROSCOPY (3 Å) | | Cite: | Structure-based design of non-hypertrophic apelin receptor modulator.
Cell, 187, 2024
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8XZJ
 | | Cryo-EM structure of the WN353-bound human APLNR-Gi complex | | Descriptor: | Apelin receptor, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | | Authors: | Wang, W, Ji, S, Zhang, Y. | | Deposit date: | 2024-01-21 | | Release date: | 2024-03-20 | | Last modified: | 2024-03-27 | | Method: | ELECTRON MICROSCOPY (3 Å) | | Cite: | Structure-based design of non-hypertrophic apelin receptor modulator.
Cell, 187, 2024
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8XZG
 | | Cryo-EM structure of the [Pyr1]-apelin-13-bound human APLNR-Gi complex | | Descriptor: | Apelin receptor, Apelin-13, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | | Authors: | Wang, W, Ji, S, Zhang, Y. | | Deposit date: | 2024-01-21 | | Release date: | 2024-03-27 | | Method: | ELECTRON MICROSCOPY (3.2 Å) | | Cite: | Structure-based design of non-hypertrophic apelin receptor modulator.
Cell, 187, 2024
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8XZI
 | | Cryo-EM structure of the CMF-019-bound human APLNR-Gi complex | | Descriptor: | (3~{S})-5-methyl-3-[[1-pentan-3-yl-2-(thiophen-2-ylmethyl)benzimidazol-5-yl]carbonylamino]hexanoic acid, Apelin receptor, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | | Authors: | Wang, W, Ji, S, Zhang, Y. | | Deposit date: | 2024-01-21 | | Release date: | 2024-03-20 | | Last modified: | 2024-03-27 | | Method: | ELECTRON MICROSCOPY (2.7 Å) | | Cite: | Structure-based design of non-hypertrophic apelin receptor modulator.
Cell, 187, 2024
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8XZH
 | | Cryo-EM structure of the MM07-bound human APLNR-Gi complex | | Descriptor: | Apelin receptor, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | | Authors: | Wang, W, Ji, S, Zhang, Y. | | Deposit date: | 2024-01-21 | | Release date: | 2024-03-20 | | Last modified: | 2024-03-27 | | Method: | ELECTRON MICROSCOPY (2.6 Å) | | Cite: | Structure-based design of non-hypertrophic apelin receptor modulator.
Cell, 187, 2024
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6NXJ
 | | Flavin Transferase ApbE from Vibrio cholerae, H257G mutant | | Descriptor: | FAD:protein FMN transferase, FLAVIN-ADENINE DINUCLEOTIDE, MAGNESIUM ION | | Authors: | Osipiuk, J, Fang, X, Chakravarthy, S, Juarez, O, Joachimiak, A, Center for Structural Genomics of Infectious Diseases (CSGID) | | Deposit date: | 2019-02-08 | | Release date: | 2019-03-13 | | Last modified: | 2023-10-11 | | Method: | X-RAY DIFFRACTION (1.92 Å) | | Cite: | Conserved residue His-257 ofVibrio choleraeflavin transferase ApbE plays a critical role in substrate binding and catalysis.
J.Biol.Chem., 294, 2019
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6NXI
 | | Flavin Transferase ApbE from Vibrio cholerae | | Descriptor: | 1,2-ETHANEDIOL, FAD:protein FMN transferase, FLAVIN-ADENINE DINUCLEOTIDE, ... | | Authors: | Osipiuk, J, Fang, X, Chakravarthy, S, Juarez, O, Joachimiak, A, Center for Structural Genomics of Infectious Diseases (CSGID) | | Deposit date: | 2019-02-08 | | Release date: | 2019-03-13 | | Last modified: | 2024-03-06 | | Method: | X-RAY DIFFRACTION (1.61 Å) | | Cite: | Conserved residue His-257 ofVibrio choleraeflavin transferase ApbE plays a critical role in substrate binding and catalysis.
J.Biol.Chem., 294, 2019
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7E7B
 | | Cryo-EM structure of the SARS-CoV-2 furin site mutant S-Trimer from a subunit vaccine candidate | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-hydroxyethyl 2-deoxy-3,5-bis-O-(2-hydroxyethyl)-6-O-(2-{[(9E)-octadec-9-enoyl]oxy}ethyl)-alpha-L-xylo-hexofuranoside, ... | | Authors: | Zheng, S, Ma, J. | | Deposit date: | 2021-02-25 | | Release date: | 2021-03-24 | | Last modified: | 2022-12-07 | | Method: | ELECTRON MICROSCOPY (2.6 Å) | | Cite: | Cryo-EM structure of S-Trimer, a subunit vaccine candidate for COVID-19.
J.Virol., 95, 2021
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7E7D
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2ECK
 | | STRUCTURE OF PHOSPHOTRANSFERASE | | Descriptor: | ADENOSINE MONOPHOSPHATE, ADENOSINE-5'-DIPHOSPHATE, ADENYLATE KINASE | | Authors: | Berry, M.B, Bilderback, T, Glaser, M, Phillips Jr, G.N. | | Deposit date: | 1996-12-16 | | Release date: | 1997-03-12 | | Last modified: | 2024-02-14 | | Method: | X-RAY DIFFRACTION (2.8 Å) | | Cite: | Crystal structure of ADP/AMP complex of Escherichia coli adenylate kinase.
Proteins, 62, 2006
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5X0S
 | | Solution NMR structure of peptide toxin SsTx from Scolopendra subspinipes mutilans | | Descriptor: | SsTx | | Authors: | Wu, F, Luo, L, Qu, D, Zhang, L, Tian, C, Lai, R. | | Deposit date: | 2017-01-23 | | Release date: | 2018-01-24 | | Last modified: | 2023-06-14 | | Method: | SOLUTION NMR | | Cite: | Centipedes subdue giant prey by blocking KCNQ channels
Proc. Natl. Acad. Sci. U.S.A., 115, 2018
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7W3Y
 | | CryoEM structure of human Kv4.3 | | Descriptor: | Isoform 2 of Potassium voltage-gated channel subfamily D member 3 | | Authors: | Ma, D.M, Guo, J.T. | | Deposit date: | 2021-11-26 | | Release date: | 2022-11-02 | | Last modified: | 2024-06-26 | | Method: | ELECTRON MICROSCOPY (3 Å) | | Cite: | Structural basis for the gating modulation of Kv4.3 by auxiliary subunits.
Cell Res., 32, 2022
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7W6S
 | | CryoEM structure of human KChIP2-Kv4.3 complex | | Descriptor: | Isoform 2 of Potassium voltage-gated channel subfamily D member 3, Kv channel-interacting protein 2 | | Authors: | Ma, D.M, Guo, J.T. | | Deposit date: | 2021-12-02 | | Release date: | 2022-11-02 | | Last modified: | 2024-06-26 | | Method: | ELECTRON MICROSCOPY (2.8 Å) | | Cite: | Structural basis for the gating modulation of Kv4.3 by auxiliary subunits.
Cell Res., 32, 2022
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7W6T
 | | CryoEM structure of human KChIP1-Kv4.3-DPP6 complex | | Descriptor: | Dipeptidyl aminopeptidase-like protein 6, Isoform 2 of Potassium voltage-gated channel subfamily D member 3, Kv channel-interacting protein 1 | | Authors: | Ma, D.M, Guo, J.T. | | Deposit date: | 2021-12-02 | | Release date: | 2022-11-02 | | Method: | ELECTRON MICROSCOPY (3.85 Å) | | Cite: | Structural basis for the gating modulation of Kv4.3 by auxiliary subunits.
Cell Res., 32, 2022
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7W6N
 | | CryoEM structure of human KChIP1-Kv4.3 complex | | Descriptor: | Isoform 2 of Potassium voltage-gated channel subfamily D member 3, Kv channel-interacting protein 1 | | Authors: | Ma, D.M, Guo, J.T. | | Deposit date: | 2021-12-02 | | Release date: | 2022-11-02 | | Last modified: | 2024-06-26 | | Method: | ELECTRON MICROSCOPY (3.4 Å) | | Cite: | Structural basis for the gating modulation of Kv4.3 by auxiliary subunits.
Cell Res., 32, 2022
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