7WNQ
 
 | | Cryo-EM structure of AtSLAC1 S59A mutant | | Descriptor: | Guard cell S-type anion channel SLAC1 | | Authors: | Sun, L, Liu, X, Li, Y. | | Deposit date: | 2022-01-19 | | Release date: | 2022-04-13 | | Last modified: | 2024-06-26 | | Method: | ELECTRON MICROSCOPY (2.7 Å) | | Cite: | Structure of the Arabidopsis guard cell anion channel SLAC1 suggests activation mechanism by phosphorylation.
Nat Commun, 13, 2022
|
|
7XML
 | | Cryo-EM structure of PEIP-Bs_enolase complex | | Descriptor: | Enolase, MAGNESIUM ION, Putative gene 60 protein | | Authors: | Li, S, Zhang, K. | | Deposit date: | 2022-04-26 | | Release date: | 2022-07-27 | | Last modified: | 2024-07-03 | | Method: | ELECTRON MICROSCOPY (3.2 Å) | | Cite: | Bacteriophage protein PEIP is a potent Bacillus subtilis enolase inhibitor.
Cell Rep, 40, 2022
|
|
7YB1
 | | Crystal Structure of anthrol reductase (CbAR) in complex with NADP+ | | Descriptor: | NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, Versicolorin reductase | | Authors: | Hou, X.D, Rao, Y.J. | | Deposit date: | 2022-06-28 | | Release date: | 2023-06-07 | | Last modified: | 2023-11-08 | | Method: | X-RAY DIFFRACTION (3.3 Å) | | Cite: | Structural analysis of an anthrol reductase inspires enantioselective synthesis of enantiopure hydroxycycloketones and beta-halohydrins.
Nat Commun, 14, 2023
|
|
7YB2
 | | Crystal Structure of anthrol reductase (CbAR) in complex with NADP+ and emodin | | Descriptor: | 3-METHYL-1,6,8-TRIHYDROXYANTHRAQUINONE, GLYCEROL, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... | | Authors: | Hou, X.D, Rao, Y.J. | | Deposit date: | 2022-06-28 | | Release date: | 2023-06-07 | | Last modified: | 2023-11-29 | | Method: | X-RAY DIFFRACTION (1.85 Å) | | Cite: | Structural analysis of an anthrol reductase inspires enantioselective synthesis of enantiopure hydroxycycloketones and beta-halohydrins.
Nat Commun, 14, 2023
|
|
7BPI
 | | The crystal structue of PDE10A complexed with 14 | | Descriptor: | 8-[(E)-2-[5-methyl-1-[3-[3-(4-methylpiperazin-1-yl)propoxy]phenyl]benzimidazol-2-yl]ethenyl]quinoline, MAGNESIUM ION, ZINC ION, ... | | Authors: | Yang, Y, Zhang, S, Zhou, Q, Huang, Y.-Y, Guo, L, Luo, H.-B. | | Deposit date: | 2020-03-22 | | Release date: | 2021-01-27 | | Last modified: | 2023-11-29 | | Method: | X-RAY DIFFRACTION (2.4000864 Å) | | Cite: | Discovery of highly selective and orally available benzimidazole-based phosphodiesterase 10 inhibitors with improved solubility and pharmacokinetic properties for treatment of pulmonary arterial hypertension.
Acta Pharm Sin B, 10, 2020
|
|
7E8O
 | |
7E8J
 | |
7E8K
 | |
7VRB
 | | Structure of the Human BRG1/SS18 complex | | Descriptor: | SMARCA4 protein,Protein SSXT | | Authors: | Cheng, Y, Chen, F, Zhou, H, Long, J. | | Deposit date: | 2021-10-22 | | Release date: | 2022-05-25 | | Last modified: | 2024-05-29 | | Method: | X-RAY DIFFRACTION (2.389 Å) | | Cite: | Phase transition and remodeling complex assembly are important for SS18-SSX oncogenic activity in synovial sarcomas.
Nat Commun, 13, 2022
|
|
7BPB
 | | Human AAA+ ATPase VCP mutant - T76E, AMP-PNP bound form, Conformation I | | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, Transitional endoplasmic reticulum ATPase | | Authors: | Yang, C, Zhang, H. | | Deposit date: | 2020-03-22 | | Release date: | 2021-03-31 | | Last modified: | 2022-04-27 | | Method: | ELECTRON MICROSCOPY (4.3 Å) | | Cite: | The phosphorylation and dephosphorylation switch of VCP/p97 regulates the architecture of centrosome and spindle.
Cell Death Differ., 2022
|
|
7BP8
 | | Human AAA+ ATPase VCP mutant - T76A, ADP-bound form | | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, Transitional endoplasmic reticulum ATPase | | Authors: | Yang, C, Zhang, H. | | Deposit date: | 2020-03-21 | | Release date: | 2021-03-31 | | Last modified: | 2024-05-29 | | Method: | ELECTRON MICROSCOPY (3.9 Å) | | Cite: | The phosphorylation and dephosphorylation switch of VCP/p97 regulates the architecture of centrosome and spindle.
Cell Death Differ., 2022
|
|
7BP9
 | | Human AAA+ ATPase VCP mutant - T76E, ADP-bound form | | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, Transitional endoplasmic reticulum ATPase | | Authors: | Yang, C, Zhang, H. | | Deposit date: | 2020-03-21 | | Release date: | 2021-03-31 | | Last modified: | 2024-05-29 | | Method: | ELECTRON MICROSCOPY (3.6 Å) | | Cite: | The phosphorylation and dephosphorylation switch of VCP/p97 regulates the architecture of centrosome and spindle.
Cell Death Differ., 2022
|
|
7BPA
 | | Human AAA+ ATPase VCP mutant - T76A, AMP-PNP-bound form, Conformation I | | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, Transitional endoplasmic reticulum ATPase | | Authors: | Yang, C, Zhang, H. | | Deposit date: | 2020-03-21 | | Release date: | 2021-03-31 | | Last modified: | 2022-04-27 | | Method: | ELECTRON MICROSCOPY (3.3 Å) | | Cite: | The phosphorylation and dephosphorylation switch of VCP/p97 regulates the architecture of centrosome and spindle.
Cell Death Differ., 2022
|
|
7Y56
 | |
7Y57
 | |
7Y9U
 | | Structure of the auxin exporter PIN1 in Arabidopsis thaliana in the NPA-bound state | | Descriptor: | 2-(naphthalen-1-ylcarbamoyl)benzoic acid, Auxin efflux carrier component 1, nanobody | | Authors: | Sun, L, Liu, X, Yang, Z, Xia, J. | | Deposit date: | 2022-06-26 | | Release date: | 2022-09-07 | | Last modified: | 2022-09-28 | | Method: | ELECTRON MICROSCOPY (3.3 Å) | | Cite: | Structural insights into auxin recognition and efflux by Arabidopsis PIN1.
Nature, 609, 2022
|
|
7Y9T
 | | Structure of the auxin exporter PIN1 in Arabidopsis thaliana in the apo state | | Descriptor: | Auxin efflux carrier component 1, nanobody | | Authors: | Sun, L, Liu, X, Yang, Z, Xia, J. | | Deposit date: | 2022-06-26 | | Release date: | 2022-09-07 | | Last modified: | 2022-09-28 | | Method: | ELECTRON MICROSCOPY (3.1 Å) | | Cite: | Structural insights into auxin recognition and efflux by Arabidopsis PIN1.
Nature, 609, 2022
|
|
7Y9V
 | | Structure of the auxin exporter PIN1 in Arabidopsis thaliana in the IAA-bound state | | Descriptor: | 1H-INDOL-3-YLACETIC ACID, Auxin efflux carrier component 1, nanobody | | Authors: | Sun, L, Liu, X, Yang, Z, Xia, J. | | Deposit date: | 2022-06-26 | | Release date: | 2022-09-07 | | Last modified: | 2022-09-28 | | Method: | ELECTRON MICROSCOPY (3.2 Å) | | Cite: | Structural insights into auxin recognition and efflux by Arabidopsis PIN1.
Nature, 609, 2022
|
|
7XJA
 | | TMD masked refine map of human ClC-2 | | Descriptor: | Chloride channel protein 2 | | Authors: | Wang, L. | | Deposit date: | 2022-04-15 | | Release date: | 2023-05-17 | | Last modified: | 2023-11-15 | | Method: | ELECTRON MICROSCOPY (3.5 Å) | | Cite: | Cryo-EM structures of ClC-2 chloride channel reveal the blocking mechanism of its specific inhibitor AK-42
Nat Commun, 14, 2023
|
|
7XF5
 | | Full length human CLC-2 channel in apo state | | Descriptor: | Chloride channel protein 2 | | Authors: | Wang, L. | | Deposit date: | 2022-04-01 | | Release date: | 2023-05-03 | | Last modified: | 2023-11-15 | | Method: | ELECTRON MICROSCOPY (3.9 Å) | | Cite: | Cryo-EM structures of ClC-2 chloride channel reveal the blocking mechanism of its specific inhibitor AK-42
Nat Commun, 14, 2023
|
|
7WIU
 | | Cryo-EM structure of Mycobacterium tuberculosis irtAB in inward-facing state | | Descriptor: | Mycobactin import ATP-binding/permease protein IrtA, Mycobactin import ATP-binding/permease protein IrtB | | Authors: | Zhang, B, Sun, S, Yang, H, Rao, Z. | | Deposit date: | 2022-01-05 | | Release date: | 2023-01-25 | | Last modified: | 2024-04-10 | | Method: | ELECTRON MICROSCOPY (3.48 Å) | | Cite: | Cryo-EM structures for the Mycobacterium tuberculosis iron-loaded siderophore transporter IrtAB.
Protein Cell, 14, 2023
|
|
7WIX
 | | Cryo-EM structure of Mycobacterium tuberculosis irtAB in complex with ADP | | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, Mycobactin import ATP-binding/permease protein IrtA, ... | | Authors: | Zhang, B, Sun, S, Yang, H, Rao, Z. | | Deposit date: | 2022-01-05 | | Release date: | 2023-01-25 | | Last modified: | 2024-04-10 | | Method: | ELECTRON MICROSCOPY (3.53 Å) | | Cite: | Cryo-EM structures for the Mycobacterium tuberculosis iron-loaded siderophore transporter IrtAB.
Protein Cell, 14, 2023
|
|
7WIV
 | | Cryo-EM structure of Mycobacterium tuberculosis irtAB in complex with an AMP-PNP | | Descriptor: | Mycobactin import ATP-binding/permease protein IrtA, Mycobactin import ATP-binding/permease protein IrtB, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER | | Authors: | Zhang, B, Sun, S, Yang, H, Rao, Z. | | Deposit date: | 2022-01-05 | | Release date: | 2023-01-25 | | Last modified: | 2024-04-10 | | Method: | ELECTRON MICROSCOPY (2.88 Å) | | Cite: | Cryo-EM structures for the Mycobacterium tuberculosis iron-loaded siderophore transporter IrtAB.
Protein Cell, 14, 2023
|
|
7WIW
 | | Cryo-EM structure of Mycobacterium tuberculosis irtAB complexed with ATP in an occluded conformation | | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, Mycobactin import ATP-binding/permease protein IrtA, ... | | Authors: | Zhang, B, Sun, S, Yang, H, Rao, Z. | | Deposit date: | 2022-01-05 | | Release date: | 2023-01-25 | | Last modified: | 2024-04-10 | | Method: | ELECTRON MICROSCOPY (3.12 Å) | | Cite: | Cryo-EM structures for the Mycobacterium tuberculosis iron-loaded siderophore transporter IrtAB.
Protein Cell, 14, 2023
|
|
5GSA
 | | EED in complex with an allosteric PRC2 inhibitor | | Descriptor: | Histone-lysine N-methyltransferase EZH2, N-(furan-2-ylmethyl)-8-(4-methylsulfonylphenyl)-[1,2,4]triazolo[4,3-c]pyrimidin-5-amine, Polycomb protein EED | | Authors: | Zhao, K, Zhao, M, Luo, X, Zhang, H. | | Deposit date: | 2016-08-15 | | Release date: | 2017-02-01 | | Last modified: | 2024-10-16 | | Method: | X-RAY DIFFRACTION (2.49 Å) | | Cite: | An allosteric PRC2 inhibitor targeting the H3K27me3 binding pocket of
Nat. Chem. Biol., 13, 2017
|
|
