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7T0B
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BU of 7t0b by Molmil
Cryptococcus neoformans protein farnesyltransferase in complex with FPP and inhibitor 2g
Descriptor: (2R)-3-(cyclohexylamino)-2-hydroxypropane-1-sulfonic acid, (5S)-5-butyl-4-({1-[(4-fluorophenyl)methyl]-1H-imidazol-5-yl}methyl)-1-[3-(trifluoromethoxy)phenyl]piperazin-2-one, 1,2-ETHANEDIOL, ...
Authors:Wang, Y, Shi, Y, Beese, L.S.
Deposit date:2021-11-29
Release date:2022-11-09
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.026 Å)
Cite:Structure-Guided Discovery of Potent Antifungals that Prevent Ras Signaling by Inhibiting Protein Farnesyltransferase.
J.Med.Chem., 65, 2022
7T0A
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BU of 7t0a by Molmil
Cryptococcus neoformans protein farnesyltransferase co-crystallized with FPP and inhibitor 2f
Descriptor: (2R)-3-(cyclohexylamino)-2-hydroxypropane-1-sulfonic acid, (5S)-4-({1-[(4-bromophenyl)methyl]-1H-imidazol-5-yl}methyl)-5-butyl-1-[3-(trifluoromethoxy)phenyl]piperazin-2-one, 1,2-ETHANEDIOL, ...
Authors:Wang, Y, Shi, Y, Beese, L.S.
Deposit date:2021-11-29
Release date:2022-11-09
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.099 Å)
Cite:Structure-Guided Discovery of Potent Antifungals that Prevent Ras Signaling by Inhibiting Protein Farnesyltransferase.
J.Med.Chem., 65, 2022
7T09
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BU of 7t09 by Molmil
Cryptococcus neoformans protein farnesyltransferase in complex with FPP and inhibitor 2d
Descriptor: (2R)-3-(cyclohexylamino)-2-hydroxypropane-1-sulfonic acid, 1,2-ETHANEDIOL, 4-{[5-({(2S)-2-butyl-5-oxo-4-[3-(trifluoromethoxy)phenyl]piperazin-1-yl}methyl)-1H-imidazol-1-yl]methyl}benzonitrile, ...
Authors:Wang, Y, Shi, Y, Beese, L.S.
Deposit date:2021-11-29
Release date:2022-11-09
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (1.984 Å)
Cite:Structure-Guided Discovery of Potent Antifungals that Prevent Ras Signaling by Inhibiting Protein Farnesyltransferase.
J.Med.Chem., 65, 2022
7T08
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BU of 7t08 by Molmil
Cryptococcus neoformans protein farnesyltransferase in complex with FPP and inhibitor 2q
Descriptor: (2R)-3-(cyclohexylamino)-2-hydroxypropane-1-sulfonic acid, 1,2-ETHANEDIOL, 4-{[5-({(2S)-2-butyl-5-oxo-4-[3-(trifluoromethoxy)phenyl]piperazin-1-yl}methyl)-1H-imidazol-1-yl]methyl}-2-fluorobenzonitrile, ...
Authors:Wang, Y, Shi, Y, Beese, L.S.
Deposit date:2021-11-29
Release date:2022-11-09
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (1.803 Å)
Cite:Structure-Guided Discovery of Potent Antifungals that Prevent Ras Signaling by Inhibiting Protein Farnesyltransferase.
J.Med.Chem., 65, 2022
3VB1
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BU of 3vb1 by Molmil
Crystal Structure of Anopholes gambiae odorant binding protein 20 in open state
Descriptor: ACETIC ACID, AGAP005208-PA
Authors:Ziemba, B.P, Jones, D.N.
Deposit date:2011-12-30
Release date:2012-10-17
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:A novel mechanism of ligand binding and release in the odorant binding protein 20 from the malaria mosquito Anopheles gambiae.
Protein Sci., 22, 2013
3PX6
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BU of 3px6 by Molmil
Crystal Structure of Bacillus DNA Polymerase I Large Fragment Bound to DNA and ddCTP-dA Mismatch (tautomer) in Closed Conformation
Descriptor: 2',3'-DIDEOXYCYTIDINE 5'-TRIPHOSPHATE, DNA (5'-D(*C*AP*TP*AP*GP*GP*AP*GP*TP*CP*AP*GP*G)-3'), DNA (5'-D(*CP*CP*TP*GP*AP*CP*TP*CP*(DOC))-3'), ...
Authors:Wang, W, Beese, L.S.
Deposit date:2010-12-09
Release date:2011-10-19
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (1.59 Å)
Cite:Structural evidence for the rare tautomer hypothesis of spontaneous mutagenesis.
Proc.Natl.Acad.Sci.USA, 108, 2011
3PV8
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BU of 3pv8 by Molmil
Crystal Structure of Bacillus DNA Polymerase I Large Fragment Bound to DNA and ddTTP-dA in Closed Conformation
Descriptor: 2',3'-DIDEOXY-THYMIDINE-5'-TRIPHOSPHATE, DNA (5'-D(*C*AP*TP*AP*AP*GP*AP*GP*TP*CP*AP*GP*G)-3'), DNA (5'-D(*CP*CP*TP*GP*AP*CP*TP*CP*(2DT))-3'), ...
Authors:Wang, W, Beese, L.S.
Deposit date:2010-12-06
Release date:2011-10-19
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (1.52 Å)
Cite:Structural evidence for the rare tautomer hypothesis of spontaneous mutagenesis.
Proc.Natl.Acad.Sci.USA, 108, 2011
3PX4
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BU of 3px4 by Molmil
Crystal Structure of Bacillus DNA Polymerase I Large Fragment Bound to DNA and ddCTP-dA Mismatch (wobble) in Ajar Conformation
Descriptor: 2',3'-DIDEOXYCYTIDINE 5'-TRIPHOSPHATE, DNA (5'-D(*CP*AP*TP*AP*GP*GP*AP*GP*TP*CP*AP*GP*G)-3'), DNA (5'-D(*CP*CP*TP*GP*AP*CP*TP*CP*(DOC))-3'), ...
Authors:Wang, W, Beese, L.S.
Deposit date:2010-12-09
Release date:2011-10-19
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (1.582 Å)
Cite:Structural evidence for the rare tautomer hypothesis of spontaneous mutagenesis.
Proc.Natl.Acad.Sci.USA, 108, 2011
2ZF9
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BU of 2zf9 by Molmil
Crystal structure of a type III cohesin module from the cellulosomal ScaE cell-surface anchoring scaffoldin of Ruminococcus flavefaciens
Descriptor: CHLORIDE ION, GLYCEROL, ScaE cell-surface anchored scaffoldin protein
Authors:Frolow, F, Bayer, E, Alber, O.
Deposit date:2007-12-26
Release date:2008-12-30
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Cohesin diversity revealed by the crystal structure of the anchoring cohesin from Ruminococcus flavefaciens.
Proteins, 77, 2009
4L9P
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BU of 4l9p by Molmil
Crystal structure of Aspergillus fumigatus protein farnesyltransferase complexed with the FII analog, FPT-II, and the KCVVM peptide
Descriptor: 1,2-ETHANEDIOL, CHLORIDE ION, CaaX farnesyltransferase alpha subunit Ram2, ...
Authors:Mabanglo, M.F, Hast, M.A, Beese, L.S.
Deposit date:2013-06-18
Release date:2014-01-01
Last modified:2024-04-03
Method:X-RAY DIFFRACTION (1.45 Å)
Cite:Crystal structures of the fungal pathogen Aspergillus fumigatus protein farnesyltransferase complexed with substrates and inhibitors reveal features for antifungal drug design.
Protein Sci., 23, 2014
3Q78
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BU of 3q78 by Molmil
Cryptococcus neoformans protein farnesyltransferase in complex with FSPP and DDPTASACNIQ peptide
Descriptor: (2S)-3-(cyclohexylamino)-2-hydroxypropane-1-sulfonic acid, Farnesyltransferase alpha subunit, Farnesyltransferase beta subunit, ...
Authors:Hast, M.A, Beese, L.S.
Deposit date:2011-01-04
Release date:2011-08-03
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structures of Cryptococcus neoformans Protein Farnesyltransferase Reveal Strategies for Developing Inhibitors That Target Fungal Pathogens.
J.Biol.Chem., 286, 2011
3Q73
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BU of 3q73 by Molmil
Cryptococcus neoformans protein farnesyltransferase, apo enzyme
Descriptor: (2S)-3-(cyclohexylamino)-2-hydroxypropane-1-sulfonic acid, Farnesyltransferase, alpha subunit, ...
Authors:Hast, M.A, Beese, L.S.
Deposit date:2011-01-04
Release date:2011-08-03
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structures of Cryptococcus neoformans Protein Farnesyltransferase Reveal Strategies for Developing Inhibitors That Target Fungal Pathogens.
J.Biol.Chem., 286, 2011
4LNG
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BU of 4lng by Molmil
Aspergillus fumigatus protein farnesyltransferase complex with farnesyldiphosphate and tipifarnib
Descriptor: 1,2-ETHANEDIOL, 6-[(S)-AMINO(4-CHLOROPHENYL)(1-METHYL-1H-IMIDAZOL-5-YL)METHYL]-4-(3-CHLOROPHENYL)-1-METHYLQUINOLIN-2(1H)-ONE, CaaX farnesyltransferase alpha subunit Ram2, ...
Authors:Mabanglo, M.F, Hast, M.A, Beese, L.S.
Deposit date:2013-07-11
Release date:2014-01-01
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (1.905 Å)
Cite:Crystal structures of the fungal pathogen Aspergillus fumigatus protein farnesyltransferase complexed with substrates and inhibitors reveal features for antifungal drug design.
Protein Sci., 23, 2014
3V2L
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BU of 3v2l by Molmil
Structure of Anopheles gambiae odorant binding protein 20 bound to polyethylene glycol
Descriptor: AGAP005208-PA, TETRAETHYLENE GLYCOL
Authors:Ziemba, B.P, Jones, D.N.
Deposit date:2011-12-12
Release date:2012-10-17
Last modified:2012-12-26
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:A novel mechanism of ligand binding and release in the odorant binding protein 20 from the malaria mosquito Anopheles gambiae.
Protein Sci., 22, 2013
4LNB
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BU of 4lnb by Molmil
Aspergillus fumigatus protein farnesyltransferase ternary complex with farnesyldiphosphate and ethylenediamine scaffold inhibitor 5
Descriptor: 1,2-ETHANEDIOL, CaaX farnesyltransferase alpha subunit Ram2, CaaX farnesyltransferase beta subunit Ram1, ...
Authors:Mabanglo, M.F, Hast, M.A, Beese, L.S.
Deposit date:2013-07-11
Release date:2014-01-01
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (1.752 Å)
Cite:Crystal structures of the fungal pathogen Aspergillus fumigatus protein farnesyltransferase complexed with substrates and inhibitors reveal features for antifungal drug design.
Protein Sci., 23, 2014
3Q79
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BU of 3q79 by Molmil
Cryptococcus neoformans protein farnesyltransferase in complex with farnesyl-DDPTASACNIQ product
Descriptor: (2S)-3-(cyclohexylamino)-2-hydroxypropane-1-sulfonic acid, FARNESYL, Farnesyltransferase alpha subunit, ...
Authors:Hast, M.A, Beese, L.S.
Deposit date:2011-01-04
Release date:2011-08-03
Last modified:2011-10-19
Method:X-RAY DIFFRACTION (2.506 Å)
Cite:Structures of Cryptococcus neoformans Protein Farnesyltransferase Reveal Strategies for Developing Inhibitors That Target Fungal Pathogens.
J.Biol.Chem., 286, 2011
3Q7A
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BU of 3q7a by Molmil
Cryptococcus neoformans protein farnesyltransferase in complex with FPP and L-778,123
Descriptor: (2R)-3-(cyclohexylamino)-2-hydroxypropane-1-sulfonic acid, 4-[(5-{[4-(3-CHLOROPHENYL)-3-OXOPIPERAZIN-1-YL]METHYL}-1H-IMIDAZOL-1-YL)METHYL]BENZONITRILE, FARNESYL DIPHOSPHATE, ...
Authors:Hast, M.A, Beese, L.S.
Deposit date:2011-01-04
Release date:2011-08-03
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structures of Cryptococcus neoformans Protein Farnesyltransferase Reveal Strategies for Developing Inhibitors That Target Fungal Pathogens.
J.Biol.Chem., 286, 2011
3Q75
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BU of 3q75 by Molmil
Cryptococcus neoformans protein farnesyltransferase in complex with FPT-II and TKCVVM peptide
Descriptor: (2S)-3-(cyclohexylamino)-2-hydroxypropane-1-sulfonic acid, Farnesyltransferase alpha subunit, Farnesyltransferase beta subunit, ...
Authors:Hast, M.A, Beese, L.S.
Deposit date:2011-01-04
Release date:2011-08-03
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (2.14 Å)
Cite:Structures of Cryptococcus neoformans Protein Farnesyltransferase Reveal Strategies for Developing Inhibitors That Target Fungal Pathogens.
J.Biol.Chem., 286, 2011
3E31
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BU of 3e31 by Molmil
H. influenzae beta-carbonic anhydrase, variant V47A
Descriptor: Carbonic anhydrase 2, ZINC ION
Authors:Rowlett, R.S, Lee, J.
Deposit date:2008-08-05
Release date:2009-08-18
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2.95 Å)
Cite:Evidence for a bicarbonate "escort" site in Haemophilus influenzae beta-carbonic anhydrase .
Biochemistry, 49, 2010
3Q7F
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BU of 3q7f by Molmil
Cryptococcus neoformans protein farnesyltransferase in complex with FPP and ethylenediamine inhibitor 1
Descriptor: (2S)-3-(cyclohexylamino)-2-hydroxypropane-1-sulfonic acid, FARNESYL DIPHOSPHATE, Farnesyltransferase alpha subunit, ...
Authors:Hast, M.A, Beese, L.S.
Deposit date:2011-01-04
Release date:2011-08-03
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structures of Cryptococcus neoformans Protein Farnesyltransferase Reveal Strategies for Developing Inhibitors That Target Fungal Pathogens.
J.Biol.Chem., 286, 2011
4MBG
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BU of 4mbg by Molmil
Crystal structure of Aspergillus fumigatus protein farnesyltransferase binary complex with farnesyldiphosphate
Descriptor: 1,2-ETHANEDIOL, CaaX farnesyltransferase alpha subunit Ram2, CaaX farnesyltransferase beta subunit Ram1, ...
Authors:Mabanglo, M.F, Hast, M.A, Beese, L.S.
Deposit date:2013-08-19
Release date:2014-01-01
Last modified:2024-04-03
Method:X-RAY DIFFRACTION (1.74 Å)
Cite:Crystal structures of the fungal pathogen Aspergillus fumigatus protein farnesyltransferase complexed with substrates and inhibitors reveal features for antifungal drug design.
Protein Sci., 23, 2014
3PX0
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BU of 3px0 by Molmil
Crystal Structure of Bacillus DNA Polymerase I Large Fragment Bound to DNA and dCTP-dA Mismatch (tautomer) in Closed Conformation
Descriptor: 2'-DEOXYCYTIDINE-5'-TRIPHOSPHATE, DNA (5'-D(*C*AP*TP*AP*GP*GP*AP*GP*TP*CP*AP*GP*G)-3'), DNA (5'-D(*CP*CP*TP*GP*AP*CP*TP*CP*(DOC))-3'), ...
Authors:Wang, W, Beese, L.S.
Deposit date:2010-12-09
Release date:2011-10-19
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (1.73 Å)
Cite:Structural evidence for the rare tautomer hypothesis of spontaneous mutagenesis.
Proc.Natl.Acad.Sci.USA, 108, 2011
1PFK
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BU of 1pfk by Molmil
CRYSTAL STRUCTURE OF THE COMPLEX OF PHOSPHOFRUCTOKINASE FROM ESCHERICHIA COLI WITH ITS REACTION PRODUCTS
Descriptor: 1,6-di-O-phosphono-beta-D-fructofuranose, ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ...
Authors:Shirakihara, Y, Evans, P.R.
Deposit date:1988-01-25
Release date:1989-01-09
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Crystal structure of the complex of phosphofructokinase from Escherichia coli with its reaction products.
J.Mol.Biol., 204, 1988
2PFK
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BU of 2pfk by Molmil
THE CRYSTAL STRUCTURE OF UNLIGANDED PHOSPHOFRUCTOKINASE FROM ESCHERICHIA COLI
Descriptor: 6-PHOSPHOFRUCTOKINASE ISOZYME I
Authors:Rypniewski, W.R, Evans, P.R.
Deposit date:1988-01-25
Release date:1989-01-09
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Crystal structure of unliganded phosphofructokinase from Escherichia coli.
J.Mol.Biol., 207, 1989
1MCV
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BU of 1mcv by Molmil
Crystal Structure Analysis of a Hybrid Squash Inhibitor in Complex with Porcine Pancreatic Elastase
Descriptor: CALCIUM ION, Elastase 1, HEI-TOE I, ...
Authors:Ay, J, Hilpert, K, Krauss, N, Schneider-Mergener, J, Hoehne, W.
Deposit date:2002-08-06
Release date:2003-02-04
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structure of a hybrid squash inhibitor in complex with porcine pancreatic elastase at 1.8 A resolution.
Acta Crystallogr.,Sect.D, 59, 2003

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