3Q7F

Cryptococcus neoformans protein farnesyltransferase in complex with FPP and ethylenediamine inhibitor 1

Summary for 3Q7F

Entry DOI	10.2210/pdb3q7f/pdb
Related	3Q73 3Q75 3Q78 3Q79 3Q7A 3SFX 3SFY
Related PRD ID	PRD_900003
Descriptor	Farnesyltransferase alpha subunit, Farnesyltransferase beta subunit, beta-D-fructofuranose-(2-1)-alpha-D-glucopyranose, ... (9 entities in total)
Functional Keywords	protein prenyltransferase, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological source	Cryptococcus neoformans More
Total number of polymer chains	2
Total formula weight	100492.34
Authors	Hast, M.A.,Beese, L.S. (deposition date: 2011-01-04, release date: 2011-08-03, Last modification date: 2024-02-21)
Primary citation	Hast, M.A.,Nichols, C.B.,Armstrong, S.M.,Kelly, S.M.,Hellinga, H.W.,Alspaugh, J.A.,Beese, L.S. Structures of Cryptococcus neoformans Protein Farnesyltransferase Reveal Strategies for Developing Inhibitors That Target Fungal Pathogens. J.Biol.Chem., 286:35149-35162, 2011 Cited by PubMed: 21816822 DOI: 10.1074/jbc.M111.250506 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.2 Å)

Structure validation