3CNP
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![BU of 3cnp by Molmil](/molmil-images/mine/3cnp) | Crystal structure of fms1 in complex with S-N1-AcMeSpermidine | Descriptor: | FLAVIN-ADENINE DINUCLEOTIDE, GLYCEROL, N-{(1S)-3-[(4-aminobutyl)amino]-1-methylpropyl}acetamide, ... | Authors: | Huang, Q, Hao, Q. | Deposit date: | 2008-03-26 | Release date: | 2008-04-22 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Crystal structure of fms1 in complex with S-N1-AcMeSpermidine TO BE PUBLISHED
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1Q59
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![BU of 1q59 by Molmil](/molmil-images/mine/1q59) | Solution Structure of the BHRF1 Protein From Epstein-Barr Virus, a Homolog of Human Bcl-2 | Descriptor: | Early antigen protein R | Authors: | Huang, Q, Petros, A.M, Virgin, H.W, Fesik, S.W, Olejniczak, E.T. | Deposit date: | 2003-08-06 | Release date: | 2003-09-23 | Last modified: | 2024-05-22 | Method: | SOLUTION NMR | Cite: | Solution Structure of the BHRF1 Protein From Epstein-Barr Virus, a Homolog of Human Bcl-2 J.Mol.Biol., 332, 2003
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1Q2U
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![BU of 1q2u by Molmil](/molmil-images/mine/1q2u) | Crystal structure of DJ-1/RS and implication on familial Parkinson's disease | Descriptor: | RNA-binding protein regulatory subunit | Authors: | Huai, Q, Sun, Y, Wang, H, Chin, L.S, Li, L, Robinson, H, Ke, H. | Deposit date: | 2003-07-26 | Release date: | 2003-10-07 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | Crystal structure of DJ-1/RS and implication on familial Parkinson's disease Febs Lett., 549, 2003
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1Q9M
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![BU of 1q9m by Molmil](/molmil-images/mine/1q9m) | Three dimensional structures of PDE4D in complex with roliprams and implication on inhibitor selectivity | Descriptor: | ROLIPRAM, ZINC ION, cAMP-specific phosphodiesterase PDE4D2 | Authors: | Huai, Q, Wang, H, Sun, Y, Kim, H.Y, Liu, Y, Ke, H. | Deposit date: | 2003-08-25 | Release date: | 2003-09-02 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Three dimensional structures of PDE4D in complex with roliprams and implication on inhibitor selectivity Structure, 11, 2003
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1RKP
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![BU of 1rkp by Molmil](/molmil-images/mine/1rkp) | Crystal structure of PDE5A1-IBMX | Descriptor: | 3-ISOBUTYL-1-METHYLXANTHINE, MAGNESIUM ION, ZINC ION, ... | Authors: | Huai, Q, Liu, Y, Francis, S.H, Corbin, J.D, Ke, H. | Deposit date: | 2003-11-22 | Release date: | 2004-03-30 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (2.05 Å) | Cite: | Crystal structures of phosphodiesterases 4 and 5 in complex with inhibitor IBMX suggest a conformation determinant of inhibitor selectivity J.Biol.Chem., 279, 2004
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1OYN
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![BU of 1oyn by Molmil](/molmil-images/mine/1oyn) | Crystal structure of PDE4D2 in complex with (R,S)-rolipram | Descriptor: | ROLIPRAM, ZINC ION, cAMP-specific phosphodiesterase PDE4D2 | Authors: | Huai, Q, Wang, H, Sun, Y, Kim, H.Y, Liu, Y, Ke, H. | Deposit date: | 2003-04-05 | Release date: | 2003-07-15 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Three-dimensional structures of PDE4D in complex with roliprams and implication on inhibitor selectivity Structure, 11, 2003
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1PTW
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![BU of 1ptw by Molmil](/molmil-images/mine/1ptw) | |
1SSK
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![BU of 1ssk by Molmil](/molmil-images/mine/1ssk) | Structure of the N-terminal RNA-binding Domain of the SARS CoV Nucleocapsid Protein | Descriptor: | Nucleocapsid protein | Authors: | Huang, Q, Yu, L, Petros, A.M, Gunasekera, A, Liu, Z, Xu, N, Hajduk, P, Mack, J, Fesik, S.W, Olejniczak, E.T. | Deposit date: | 2004-03-24 | Release date: | 2004-06-08 | Last modified: | 2024-05-22 | Method: | SOLUTION NMR | Cite: | Structure of the N-Terminal RNA-Binding Domain of the SARS CoV Nucleocapsid Protein. Biochemistry, 43, 2004
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8KHG
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![BU of 8khg by Molmil](/molmil-images/mine/8khg) | Itaconyl-CoA hydratase PaIch | Descriptor: | CITRIC ACID, Itaconyl-CoA hydratase | Authors: | Huang, Q, Bao, R. | Deposit date: | 2023-08-21 | Release date: | 2024-05-15 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Structural and functional characterization of itaconyl-CoA hydratase and citramalyl-CoA lyase involved in itaconate metabolism of Pseudomonas aeruginosa. Structure, 2024
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8KHL
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![BU of 8khl by Molmil](/molmil-images/mine/8khl) | (S)-citramalyl-CoA lyase | Descriptor: | COENZYME A, Probable acyl-CoA lyase beta chain | Authors: | Huang, Q, Bao, R. | Deposit date: | 2023-08-22 | Release date: | 2024-05-15 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Structural and functional characterization of itaconyl-CoA hydratase and citramalyl-CoA lyase involved in itaconate metabolism of Pseudomonas aeruginosa. Structure, 2024
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5T8N
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![BU of 5t8n by Molmil](/molmil-images/mine/5t8n) | |
5T8L
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![BU of 5t8l by Molmil](/molmil-images/mine/5t8l) | |
1Y4S
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![BU of 1y4s by Molmil](/molmil-images/mine/1y4s) | Conformation rearrangement of heat shock protein 90 upon ADP binding | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, Chaperone protein htpG, MAGNESIUM ION | Authors: | Huai, Q, Wang, H, Liu, Y, Kim, H, Toft, D, Ke, H. | Deposit date: | 2004-12-01 | Release date: | 2005-04-19 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (2.9 Å) | Cite: | Structures of the N-terminal and middle domains of E. coli Hsp90 and conformation changes upon ADP binding. Structure, 13, 2005
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1Y4U
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![BU of 1y4u by Molmil](/molmil-images/mine/1y4u) | Conformation rearrangement of heat shock protein 90 upon ADP binding | Descriptor: | Chaperone protein htpG | Authors: | Huai, Q, Wang, H, Liu, Y, Kim, H, Toft, D, Ke, H. | Deposit date: | 2004-12-01 | Release date: | 2005-04-19 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (2.9 Å) | Cite: | Structures of the N-terminal and middle domains of E. coli Hsp90 and conformation changes upon ADP binding. Structure, 13, 2005
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1ZKN
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![BU of 1zkn by Molmil](/molmil-images/mine/1zkn) | Structure of PDE4D2-IBMX | Descriptor: | 3-ISOBUTYL-1-METHYLXANTHINE, MAGNESIUM ION, ZINC ION, ... | Authors: | Huai, Q, Liu, Y, Francis, S.H, Corbin, J.D, Ke, H. | Deposit date: | 2005-05-03 | Release date: | 2005-05-17 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Crystal Structures of Phosphodiesterases 4 and 5 in Complex with Inhibitor 3-Isobutyl-1-Methylxanthine Suggest a Conformation Determinant of Inhibitor Selectivity J.Biol.Chem., 279, 2004
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8ETD
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![BU of 8etd by Molmil](/molmil-images/mine/8etd) | Crystal Structure of Schizosaccharomyces pombe Rho1 | Descriptor: | GTP-binding protein rho1, GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION | Authors: | Huang, Q, Xie, J, Seetharaman, J. | Deposit date: | 2022-10-16 | Release date: | 2022-12-07 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (2.78 Å) | Cite: | Crystal Structure of Schizosaccharomyces pombe Rho1 Reveals Its Evolutionary Relationship with Other Rho GTPases. Biology (Basel), 11, 2022
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3CNS
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![BU of 3cns by Molmil](/molmil-images/mine/3cns) | |
3M7F
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![BU of 3m7f by Molmil](/molmil-images/mine/3m7f) | Crystal structure of the Nedd4 C2/Grb10 SH2 complex | Descriptor: | E3 ubiquitin-protein ligase NEDD4, Growth factor receptor-bound protein 10 | Authors: | Huang, Q, Szebenyi, M. | Deposit date: | 2010-03-16 | Release date: | 2010-10-27 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Structural Basis for the Interaction between the Growth Factor-binding Protein GRB10 and the E3 Ubiquitin Ligase NEDD4. J.Biol.Chem., 285, 2010
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5HL1
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![BU of 5hl1 by Molmil](/molmil-images/mine/5hl1) | Crystal structure of glutaminase C in complex with inhibitor CB-839 | Descriptor: | 2-(pyridin-2-yl)-N-(5-{4-[6-({[3-(trifluoromethoxy)phenyl]acetyl}amino)pyridazin-3-yl]butyl}-1,3,4-thiadiazol-2-yl)acetamide, Glutaminase kidney isoform, mitochondrial | Authors: | Huang, Q, Cerione, R.A. | Deposit date: | 2016-01-14 | Release date: | 2016-08-24 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Crystal structure of the clinically relevant glutaminase inhibitot CB-839 in complex with glutaminase C To Be Published
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2HD1
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![BU of 2hd1 by Molmil](/molmil-images/mine/2hd1) | Crystal structure of PDE9 in complex with IBMX | Descriptor: | 3-ISOBUTYL-1-METHYLXANTHINE, MAGNESIUM ION, Phosphodiesterase 9A, ... | Authors: | Huai, Q, Wang, H, Zhang, W, Colman, R.W, Robinson, H, Ke, H. | Deposit date: | 2006-06-19 | Release date: | 2006-06-27 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (2.23 Å) | Cite: | Crystal structure of phosphodiesterase 9 shows orientation variation of inhibitor IBMX binding Proc.Natl.Acad.Sci.USA, 101, 2004
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8WCO
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![BU of 8wco by Molmil](/molmil-images/mine/8wco) | (S)-citramalyl-CoA lyase | Descriptor: | ACETYL COENZYME *A, Probable acyl-CoA lyase beta chain | Authors: | Huang, Q, Bao, R. | Deposit date: | 2023-09-13 | Release date: | 2024-05-15 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Structural and functional characterization of itaconyl-CoA hydratase and citramalyl-CoA lyase involved in itaconate metabolism of Pseudomonas aeruginosa. Structure, 2024
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5WJ6
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![BU of 5wj6 by Molmil](/molmil-images/mine/5wj6) | Crystal structure of glutaminase C in complex with inhibitor 2-phenyl-N-{5-[4-({5-[(phenylacetyl)amino]-1,3,4-thiadiazol-2-yl}amino)piperidin-1-yl]-1,3,4-thiadiazol-2-yl}acetamide (UPGL-00004) | Descriptor: | 2-phenyl-N-{5-[4-({5-[(phenylacetyl)amino]-1,3,4-thiadiazol-2-yl}amino)piperidin-1-yl]-1,3,4-thiadiazol-2-yl}acetamide, Glutaminase kidney isoform, mitochondrial | Authors: | Huang, Q, Cerione, R.A. | Deposit date: | 2017-07-21 | Release date: | 2018-01-10 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (2.445 Å) | Cite: | Characterization of the interactions of potent allosteric inhibitors with glutaminase C, a key enzyme in cancer cell glutamine metabolism. J. Biol. Chem., 293, 2018
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2FD6
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![BU of 2fd6 by Molmil](/molmil-images/mine/2fd6) | Structure of Human Urokinase Plasminogen Activator in Complex with Urokinase Receptor and an anti-upar antibody at 1.9 A | Descriptor: | 1,2-ETHANEDIOL, 2-ETHOXYETHANOL, 2-acetamido-2-deoxy-alpha-D-glucopyranose, ... | Authors: | Huang, M, Huai, Q, Li, Y. | Deposit date: | 2005-12-13 | Release date: | 2006-02-21 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Structure of human urokinase plasminogen activator in complex with its receptor Science, 311, 2006
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2TIO
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![BU of 2tio by Molmil](/molmil-images/mine/2tio) | LOW PACKING DENSITY FORM OF BOVINE BETA-TRYPSIN IN CYCLOHEXANE | Descriptor: | BENZAMIDINE, CALCIUM ION, HEXANE, ... | Authors: | Huang, Q, Zhu, G, Tang, Q. | Deposit date: | 1998-09-23 | Release date: | 1998-09-30 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (1.93 Å) | Cite: | X-ray studies on two forms of bovine beta-trypsin crystals in neat cyclohexane. Biochim.Biophys.Acta, 1429, 1998
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5Y36
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![BU of 5y36 by Molmil](/molmil-images/mine/5y36) | Cryo-EM structure of SpCas9-sgRNA-DNA ternary complex | Descriptor: | CRISPR-associated endonuclease Cas9/Csn1, MAGNESIUM ION, complementary DNA strand, ... | Authors: | Huang, Q, Li, G, Huai, C. | Deposit date: | 2017-07-27 | Release date: | 2017-12-06 | Last modified: | 2024-03-27 | Method: | ELECTRON MICROSCOPY (5.2 Å) | Cite: | Structural insights into DNA cleavage activation of CRISPR-Cas9 system Nat Commun, 8, 2017
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